Recent Advances of Modern Protocol for C-C Bonds—The Suzuki Cross-Coupling

Abstract

<p class="MsoNormal"> <span lang="EN-US">Over the past 20 years, small molecule solid phase synthesis has become a powerful tool in the discovery of novel molecular materials. In the development of organic chemistry, the carbon-carbon bond formation has always been one of the most useful and fundamental reaction. The current review summarizes recent developments in metal-catalyzed coupling reactions. The following method is discussed in detail—the cross-coupling of aryl halides with aryl boronic acids (the Suzuki coupling), and the others C-C bond formation reactions as the palladium-catalyzed reaction between an aryl and (or) alkyl halide and a vinyl functionality (the Heck reaction); and the palladium-catalyzed cross-coupling reaction of organostannyl reagents with a variety of organic electrophiles (the Stille reaction)—are mentioned.</span> </p

Synthesis and Preclinical Evaluation of11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain

“…However, the protodeborylated product, which possesses affinity appreciable to SV2A (pKi 5 8.0 6 0.1) was always detected in the final product when the boronic acid precursor was used, but not present with the use of the trifluoroborate precursor. It is unclear whether this deborylated product is formed as a side reaction during the radiolabeling of the boronic acid precursor, which is known to occur particularly with electron-rich boronic acids (26), or by decomposition of the boronic acid precursor during work-up. Both base-and metal-catalyzed deboronation of boronic acids may occur under typical Suzuki-Miyaura cross-coupling reaction conditions (27,28).…”

Synthesis of 4-Methoxybiphenyl Using Pd-Containing Catalysts Based on Polymeric Matrix of Functionalized Hypercrosslinked Polystyrene

“…However, the industrial application of the majority of developed phosphorus-or nitrogencontaining ligands is limited by their high cost [1]. Besides, a common disadvantage of homogeneous catalysts is difficulty of their separation from the reaction mixture and their reuse [2].…”

“…Pd/C, which is simple in preparation and can be easily separated from the reaction mixture, is the most well-known ligandless catalyst [2][3][4][5]. Palladium salts [1,6] can be also attributed to the ligandless catalysts of the Suzuki reaction.…”

Methyl Methacrylate and Alpha-Methyl Styrene: New Strategy for Synthesis of Bloc Copolymers for Use in Potential Biomedical Applications Generated by an Ecologic Catalyst Called Maghnite (Algerian MMT)

“…The p re p ar a t io n o f p o ly ( me thy l methacrylate) (PMMA) plastics and their characteristic structure properties have been thoroughly investigated in recent years [17][18][19][20]. This polymer have a several applications such as material chemistry, biological medicine and environmental science [21][22][23][24][25].…”