Recent aspects of the effects of zinc on human health

Chasapis, Christos T.; Ntoupa, Panagoula-Stamatina A.; Spiliopoulou, Chara; Stefanidou, Maria

doi:10.1007/s00204-020-02702-9

Cited by 454 publications

(317 citation statements)

References 197 publications

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“…Some dietary components, such as B vitamins and vitamins A, D, K, and E can be synthesized by the gut microbiota and have a key role in reducing inflammation, regulating energy metabolism, enzymatic functions important for gene expression and immune response regulation throughout the life course (91,107,108). Interestingly, both zinc deficiency and dysfunction of the immune system are accompanied by impaired immune responses and systemic low-grade chronic inflammation in aged individuals (109)(110)(111)(112). Sodium chloride (NaCl) is a salt and a micronutrient that also mediates immunological effects.…”

Section: Role Of Microbiota and Dietary Antigens In The Development Omentioning

confidence: 99%

Inflammaging in Endemic Areas for Infectious Diseases

et al. 2020

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Immunosenescence is marked by a systemic process named inflammaging along with a series of defects in the immunological activity that results in poor responses to infectious agents and to vaccination. Inflammaging, a state of low-grade chronic inflammation, usually leads to chronic inflammatory diseases and frailty in the elderly. However, some elderly escape from frailty and reach advanced age free of the consequences of inflammaging. This process has been called immunological remodeling, and it is the hallmark of healthy aging as described in the studies of centenarians in Italy. The biological markers of healthy aging are still a matter of debate, and the studies on the topic have focused on inflammatory versus remodeling processes and molecules. The sub-clinical inflammatory status associated with aging might be a deleterious event for populations living in countries where chronic infectious diseases are not prevalent. Nevertheless, in other parts of the world where they are, two possibilities may occur. Inflammatory responses may have a protective effect against these infectious agents. At the same time, the long-term consequences of protective immune responses during chronic infections may result in accelerated immunosenescence in these individuals. Therefore, the biological markers of healthy aging can vary according to environmental, cultural, and geographical settings that reflect worldwide, and in a non-biased, non-westernized perspective, the changes that we experience regarding our contacts with microorganisms and the outcomes of such contacts.

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Section: Role Of Microbiota and Dietary Antigens In The Development Omentioning

confidence: 99%

Inflammaging in Endemic Areas for Infectious Diseases

et al. 2020

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“…[34,35]. Zinc has been suggested to involve in the synthesis of protein and collagen, which contribute to wound healing, while selenium supplementation has been suggested to associate with a decrement of peroxidation lipids and incidence of infectious complications, as well as better wound healing [10,[36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Relationship between dietary factors and recurrent aphthous stomatitis: A cross-sectional study

Zhou

Fan

et al. 2020

Preprint

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Background: Recurrent aphthous stomatitis (RAS), a common oral mucosal disorder characterized by chronic, inflammatory, and ovoid ulcers, has a complex aetiology. The purpose of the study was to investigate the specific dietary factors influencing the prevalence of RAS.Methods: A total of 754 participants aged 18 to 59 years in Nanjing were enrolled in this descriptive cross-sectional study. An anonymous questionnaire was adopted to investigate the distribution of RAS, dietary factors, self-reported trigger factors, and therapeutic methods.Results: Among all participants, the prevalence rate of RAS was 21.4%. The univariable analysis suggested fruits, dairy products, vegetables, and drinking water, but not fried foods, fermented foods, spicy foods, and eggs, as preventive factors of RAS. After adjusting for age and sex, multivariable regression analysis suggested fruits (adjusted odds ratio [aOR] = .430, 95% confidence interval [CI] = [.218-.847], p = .015) and drinking water (aOR = .294, 95% CI = [.119-.726], p = .008) as protective factors of RAS. Conclusion: This study suggests that consumption of fruit and drinking water is negatively associated with RAS and dietary factors play an important role in RAS development. These results imply a potential adjunctive and complementary role of food in RAS treatment and some potential, simple, and feasible means for RAS prevention.

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“…41 Zinc plays a role in cellular growth and is necessary for protein synthesis, like intercellular DNA, RNA, and cell division. 42 It is also reported that there are significantly lower serum levels of zinc in HM patients compared with healthy pregnant women which may be a contributor in its pathogenesis. 43 Meanwhile, zinc has an essential role as a protective and adjuvant therapy for COVID-19, mainly by reducing the inflammation and modulating antiviral and antibacterial immunity.…”

Section: Role Of Zin Cmentioning

confidence: 99%

COVID‐19 and hydatidiform mole

Abbas

Ahmed

Salem

et al. 2020

American J Rep Immunol

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Coronaviruses are one of the Coronaviridae family in the Nidovirales order. Coronaviruses are small in size (65-125 nm in diameter) and contain a single-stranded RNA as a nucleic material. They are characterized by having crown-like spikes on the virus' outer surface; thus, it is named coronavirus. 1 The coronaviruses are genotypically and serologically divided into four subgroups: α-, β-, γ-, and δ-CoVs. Human CoVs infections are mainly due to α-and β-subgroups like severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to β-CoVs. 2 The SARS-CoV-2 virus causing the coronavirus disease 2019 (COVID-19) was classified by the World Health Organization (WHO) as a β-CoV of group 2B. 3 The genetic sequence of SARS-CoV-2 showed more than 80% identity to SARS-CoV and 50% to the MERS-CoV; both originate in bats. 4,5 Presently, COVID-19 patients are considered to be the primary source of infection, as person-to-person transmission occurs predominantly via direct contact or through droplets during coughing or sneezing. 6 Until now, there is no proof that SARS-CoV-2 can be transmitted through aerosols or from mother to baby during pregnancy or childbirth. 6 Hence, there are no available data on the consequences of COVID-19 on the course and outcome of pregnancy; it is crucial to pay more attention to this issue, especially that COVID-19 still appears to be sweeping. Moreover, pregnant mothers are pretty more predisposed to infection by respiratory pathogens and severe pneumonia. 2 | IMMUNOLOGY AND PATHOG ENE S IS OF COVID-19 All coronaviruses have specific genes in ORF1 downstream regions that encode proteins for viral replication, nucleocapsid, and spikes formation, and the structural proteins are encoded by the four structural genes, including spike (S), envelope (E), membrane (M), and nucleocapsid (N) genes. 7 Although the genome of the SARS-CoV-2 has

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Recent aspects of the effects of zinc on human health

Cited by 454 publications

References 197 publications

Inflammaging in Endemic Areas for Infectious Diseases

Inflammaging in Endemic Areas for Infectious Diseases

Relationship between dietary factors and recurrent aphthous stomatitis: A cross-sectional study

COVID‐19 and hydatidiform mole

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