Recent development in novel drug delivery systems of herbal drugs

Chaturvedi, M.; Sinhal, Amit; Kumar, Manish; Alimuddin, Saifi

doi:10.4103/0973-8258.85155

Cited by 33 publications

(16 citation statements)

References 9 publications

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“…Analysis of C. asiatica is important to provide information on the content of asiaticoside. TLC analysis in Centella will contribute to evaluate the quality of medicine compounds (Chaturvedi et al 2011). The TLC method developed by Bele and Khale (2011), generally uses 2 variables, namely the mobile phase in the form of liquid and the stationary phase using silica gel, cellulose, or alumina.…”

Section: Discussionmentioning

confidence: 99%

The diversity of leaves and asiaticoside content on three accessions of Centella asiatica with the addition of chicken manure fertilizer

Maratul

Widyastuti²,

Supriyono

et al. 2020

Biodiversitas

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Abstract. Mumtazah HM, Supriyono, Widyastuti Y, Yunus A. 2020. The diversity of leaves and asiaticoside content on three accessions of Centella asiatica with the addition of chicken manure fertilizer. Biodiversitas 21: 1035-1040. Centella asiatica (L.) commonly known as an essential medicinal herb. This plant has high diversity, especially in leaf morphology. The main objective of this research was to determine the morphology of leaves and the effect of chicken manure dosage on the increase of asiaticoside content. The leaves of three accessions characterized, and then C. asiatica planted. The research design used a completely randomized design (CRD) factorial, with the first factor is accession (C) with 3 levels (C1: accession 1, C2: accession 2, C3: accession 3). The second factor was chicken manure with 4 levels dosage (P1: 0 ton ha-1, P2: 10 tons ha-1, P3: 15 tons ha-1 and P4: 20 tons ha-1). Asiaticoside analysis used the TLC method with chloroform: methanol: water (65:25:4) as mobile phase. The result from this research showed that the diversity in leaf morphology of three accessions is in leaf size and petiole length. Accession 3 has the widest leaf size (7.3 cm) and the longest petiole (9.8 cm), accession 2 with a leaf width of 5.8 cm and petiole length in 8.5 cm, while the accession 1 has the least leaf width (5.3 cm) and the length of the petiole is the shortest with 7.3 cm. Observation results of asiaticoside showed that the highest content of asiaticoside produced by accession 3 (0.19%), then accession 1 with a content of 0.15%, while accession 2 showed the lowest asiaticoside content (0.13%). The treatment of chicken manure addition significantly increase asiaticoside content in accessions 1 and 3, but in accession 2 it was not significantly increased. The highest content of asiaticoside (0.34%) were in accession 3 with the addition of chicken manure 20 tons ha-1 (P4).

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Section: Discussionmentioning

confidence: 99%

The diversity of leaves and asiaticoside content on three accessions of Centella asiatica with the addition of chicken manure fertilizer

Maratul

Widyastuti²,

Supriyono

et al. 2020

Biodiversitas

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“…Herbal preparations are obtained by subjecting whole plant, fragmented or cut plants, plants parts to treatments such as extraction, distillation, expression, fractionation, purification, concentration or fermentation. These include comminuted or powdered herbal substances, tinctures, extracts, essential oils, expressed juices and processed exudates [23][24].…”

Section: Herbal Drugsmentioning

confidence: 99%

Recent development in novel drug delivery systems for delivery of herbal drugs: An updates

Dongare¹,

Motule²,

Dubey³

et al. 2021

GSC Adv. Res. Rev.

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In the recent years, herbal medicines have gained worldwide attention of peoples and researchers due to their esthetic value, more patient’s compliance and prominent therapeutic effects. Novel drug delivery systems for delivery of herbal drugs possesses several advantages over conventional formulations. It includes enhancement of solubility, bioavailability, and protection from toxicity, etc. The herbal drugs can be used in a more upright course with enhanced efficacy by incorporating them into suitable dosage forms. This can be achieved by designing novel drug delivery systems for such drugs. Such systems are polymeric nanoparticles, nanocapsules, phytosomes, animations, microsphere, etc. The present article highlights the current condition of the development of novel herbal formulations and summarizes their type of active components, biological activity, and applications of novel formulations.

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“…The use of herbal extracts has various limitations such as instability, metabolism by the liver, toxic effects on other cells, and poor water solubility so that the drug levels in the blood are below the therapeutic concentration which results in low or no therapeutic effect [1]. It is necessary to develop methods to improve the delivery of herbal medicines used in diseases such as cancer and viral infections, considering that the discovery of new drugs is currently dominated by drugs with poor solubility resulting in low levels.…”

Section: Introductionmentioning

confidence: 99%

Optimization and Characterization of Formulation Self-Nanoemulsifying Drug Delivery System Ethanol Extract of Romang Parang Leaves (Boehmeria Virgata)

Magfirah¹,

Utami²

2021

Asian J Pharm Clin Res

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Objective: Parang romang (Boehmeria virgata) is one of the traditional medicines that are used empirically by Makassar tribal healers, South Sulawesi, as an antitumor drug. This traditional medicine contains secondary metabolites such as alkaloids, flavonoids, tannins, and saponins. However, secondary metabolites of those leaves extract have low solubility in water. Hence, to be formula, self-nanoemulsifying drug delivery system (SNEDDS) is one of the solutions to increase the extract solubility. Methods: The optimization of two formula optimum SNEDDS parang romang leaves (T80PGMZ and T20PGMZ) was using the simple lattice design (SLD) method which will give 28 SNEDDS formula parang romang leaves each of which the formula is tested for its characteristics as a critical point include emulsification time, % transmittance, drug loading, particle size, zeta potential, polydispersity index, and morphology particle. Results: The results of SNEDDS characterization obtained the optimum formula T80PGMZ with emulsification time 12.6 s, % transmittance 92.21%, drug loading 68.21 ppm, particle size 370.26 nm, zeta potential −31.4 mV, polydispersity index of 0.615, and regular particle morphology with spherical chunks at a magnification of 10,000 times with a particle size of 10 μm. Conclusion: SNEDDS of parang romang leaves extracts that used olive oil as oil phase, Tween 80 as a surfactant, and propylene glycol as the cosurfactant provided nanoemulsion with good characteristics.

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Recent development in novel drug delivery systems of herbal drugs

Cited by 33 publications

References 9 publications

The diversity of leaves and asiaticoside content on three accessions of Centella asiatica with the addition of chicken manure fertilizer

The diversity of leaves and asiaticoside content on three accessions of Centella asiatica with the addition of chicken manure fertilizer

Recent development in novel drug delivery systems for delivery of herbal drugs: An updates

Optimization and Characterization of Formulation Self-Nanoemulsifying Drug Delivery System Ethanol Extract of Romang Parang Leaves (Boehmeria Virgata)

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