Recent developments in biosensors for healthcare and biomedical applications: A review

Mohankumar, P.; Ajayan, J.; Mohanraj, T.; Yasodharan, R.

doi:10.1016/j.measurement.2020.108293

Cited by 184 publications

(99 citation statements)

References 275 publications

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“…The electrical signals of a FET are generally expressed as the changes in current intensities. FET is currently one of the most popular types of devices in the biosensor field due to its extreme sensitivity [144,145]. Since the amount of dopamine exocytosed from living cells is extremely low, FET appears as a good choice owing to its high sensitivity and that is why several FETs were used recently to detect dopamine from living neurons.…”

Section: Graphenementioning

confidence: 99%

Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

2021

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Neurotransmitters are biochemical molecules that transmit a signal from a neuron across the synapse to a target cell, thus being essential to the function of the central and peripheral nervous system. Dopamine is one of the most important catecholamine neurotransmitters since it is involved in many functions of the human central nervous system, including motor control, reward, or reinforcement. It is of utmost importance to quantify the amount of dopamine since abnormal levels can cause a variety of medical and behavioral problems. For instance, Parkinson’s disease is partially caused by the death of dopamine-secreting neurons. To date, various methods have been developed to measure dopamine levels, and electrochemical biosensing seems to be the most viable due to its robustness, selectivity, sensitivity, and the possibility to achieve real-time measurements. Even if the electrochemical detection is not facile due to the presence of electroactive interfering species with similar redox potentials in real biological samples, numerous strategies have been employed to resolve this issue. The objective of this paper is to review the materials (metals and metal oxides, carbon materials, polymers) that are frequently used for the electrochemical biosensing of dopamine and point out their respective advantages and drawbacks. Different types of dopamine biosensors, including (micro)electrodes, biosensing platforms, or field-effect transistors, are also described.

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Section: Graphenementioning

confidence: 99%

Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

2021

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“…The development of enzyme biosensors has improved and expedited the diagnosis of many diseases, such as diabetes, cancer, HIV, dengue, high cholesterol, and many other disorders that involve serum analysis [127,277]. To this end, the employment of enzyme biosensors present numerous positive aspects (simplicity, flexibility, cost-effectiveness, portability, and superior selectivity) [278,279].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications

et al. 2021

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Among the many biological entities employed in the development of biosensors, enzymes have attracted the most attention. Nanotechnology has been fostering excellent prospects in the development of enzymatic biosensors, since enzyme immobilization onto conductive nanostructures can improve characteristics that are crucial in biosensor transduction, such as surface-to-volume ratio, signal response, selectivity, sensitivity, conductivity, and biocatalytic activity, among others. These and other advantages of nanomaterial-based enzymatic biosensors are discussed in this work via the compilation of several reports on their applications in different industrial segments. To provide detailed insights into the state of the art of this technology, all the relevant concepts around the topic are discussed, including the properties of enzymes, the mechanisms involved in their immobilization, and the application of different enzyme-derived biosensors and nanomaterials. Finally, there is a discussion around the pressing challenges in this technology, which will be useful for guiding the development of future research in the area.

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“…[ 14 , 15 ]. Profits from the production of POCTs are expected to reach 39.96 billion dollars by the end of 2021 [ 16 ]. Basically, POCTs consist of different parts: the sensor substrate, the sample inlet, the receptor, and the response transducer.…”

Section: Introductionmentioning

confidence: 99%

“…However, in recent years, the development of bio-POCTs has increased in both the laboratory and commercial fields [ 16 ]. In this study, we will review different types of bio-POCTs, while also investigating their application in detecting and determining hazardous contaminations, such as mycotoxin, organophosphate, bacteria, and heavy metal ions.…”

Section: Introductionmentioning

confidence: 99%

Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations—A Review

Bordbar

Sheini

Hashemi³

et al. 2021

Biosensors

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The fast detection of trace amounts of hazardous contaminations can prevent serious damage to the environment. Paper-based sensors offer a new perspective on the world of analytical methods, overcoming previous limitations by fabricating a simple device with valuable benefits such as flexibility, biocompatibility, disposability, biodegradability, easy operation, large surface-to-volume ratio, and cost-effectiveness. Depending on the performance type, the device can be used to analyze the analyte in the liquid or vapor phase. For liquid samples, various structures (including a dipstick, as well as microfluidic and lateral flow) have been constructed. Paper-based 3D sensors are prepared by gluing and folding different layers of a piece of paper, being more user-friendly, due to the combination of several preparation methods, the integration of different sensor elements, and the connection between two methods of detection in a small set. Paper sensors can be used in chromatographic, electrochemical, and colorimetric processes, depending on the type of transducer. Additionally, in recent years, the applicability of these sensors has been investigated in various applications, such as food and water quality, environmental monitoring, disease diagnosis, and medical sciences. Here, we review the development (from 2010 to 2021) of paper methods in the field of the detection and determination of toxic substances.

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Recent developments in biosensors for healthcare and biomedical applications: A review

Cited by 184 publications

References 275 publications

Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

Designing of Nanomaterials-Based Enzymatic Biosensors: Synthesis, Properties, and Applications

Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations—A Review

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