Recent Developments in Nitric Oxide Donors and Delivery for Antimicrobial and Anti-Biofilm Applications

Poh, Wee Han; Rice, Scott A.

doi:10.3390/molecules27030674

Cited by 62 publications

(47 citation statements)

References 177 publications

(378 reference statements)

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“…Therefore, while the bactericidal effect of antibacterial agents on biofilm-infected sites can be enhanced in a targeted manner, the NO-mediated toxicity should also be reduced so that it can be used in clinical anti-biofilm therapy (Barraud et al, 2012). In addition, the use of NO in combination with antibiotics can enhance the NO-mediated bactericidal effect and improve the specificity of NO delivery, so the use of NO is still very promising (Poh and Rice, 2022).…”

Section: Nitric Oxidementioning

confidence: 99%

Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

et al. 2022

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Pseudomonas aeruginosa, a Gram-negative bacterium, is one of the major pathogens implicated in human opportunistic infection and a common cause of clinically persistent infections such as cystic fibrosis, urinary tract infections, and burn infections. The main reason for the persistence of P. aeruginosa infections is due to the ability of P. aeruginosa to secrete extracellular polymeric substances such as exopolysaccharides, matrix proteins, and extracellular DNA during invasion. These substances adhere to and wrap around bacterial cells to form a biofilm. Biofilm formation leads to multiple antibiotic resistance in P. aeruginosa, posing a significant challenge to conventional single antibiotic therapeutic approaches. It has therefore become particularly important to develop anti-biofilm drugs. In recent years, a number of new alternative drugs have been developed to treat P. aeruginosa infectious biofilms, including antimicrobial peptides, quorum-sensing inhibitors, bacteriophage therapy, and antimicrobial photodynamic therapy. This article briefly introduces the process and regulation of P. aeruginosa biofilm formation and reviews several developed anti-biofilm treatment technologies to provide new directions for the treatment of P. aeruginosa biofilm infection.

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Section: Nitric Oxidementioning

confidence: 99%

Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

et al. 2022

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“…Similar studies involving a combination of NO and a nanocomposite poly(vinylidene fluoride) (PVDF) membrane or other light-activated antibacterial nanomolecules have been reported. − These metal-based surfaces can be irradiated with a light source, taking advantage of the photocatalytic activity to increase the therapeutic efficacy of NO-releasing surfaces. Readers are directed to other thorough reviews for more information on NO-releasing photoactivable materials for antibiofilm applications …”

Section: Advancements In Nitric Oxide-releasing Multifunctional Biome...mentioning

confidence: 99%

Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials

Chug

Brisbois

2022

ACS Mater. Au

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Implant-associated infections arising from biofilm development are known to have detrimental effects with compromised quality of life for the patients, implying a progressing issue in healthcare. It has been a struggle for more than 50 years for the biomaterials field to achieve long-term success of medical implants by discouraging bacterial and protein adhesion without adversely affecting the surrounding tissue and cell functions. However, the rate of infections associated with medical devices is continuously escalating because of the intricate nature of bacterial biofilms, antibiotic resistance, and the lack of ability of monofunctional antibacterial materials to prevent the colonization of bacteria on the device surface. For this reason, many current strategies are focused on the development of novel antibacterial surfaces with dual antimicrobial functionality. These surfaces are based on the combination of two components into one system that can eradicate attached bacteria (antibiotics, peptides, nitric oxide, ammonium salts, light, etc.) and also resist or release adhesion of bacteria (hydrophilic polymers, zwitterionic, antiadhesive, topography, bioinspired surfaces, etc.). This review aims to outline the progress made in the field of biomedical engineering and biomaterials for the development of multifunctional antibacterial biomedical devices. Additionally, principles for material design and fabrication are highlighted using characteristic examples, with a special focus on combinational nitric oxide-releasing biomedical interfaces. A brief perspective on future research directions for engineering of dual-function antibacterial surfaces is also presented.

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“…NO is known to play an antibacterial role via the formation of RNS and induction of nitrosative stress, which mediates the bacteriostatic properties of GSNO [ 68 ]. However, the underlying molecular mechanisms were not clarified completely ( Fig.…”

Section: Antibacterial Property Of Gsno and Associated Mechanismsmentioning

confidence: 99%

Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials

Hu¹,

Ye²,

Pi³

et al. 2022

Materials Today Bio

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Recent Developments in Nitric Oxide Donors and Delivery for Antimicrobial and Anti-Biofilm Applications

Cited by 62 publications

References 177 publications

Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

Treatment of Pseudomonas aeruginosa infectious biofilms: Challenges and strategies

Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials

Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials

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