Recent Investigations for Discovery of Natural Antioxidants: A Comprehensive Review

Parveen, Amna; Akash, Muhammad Sajid Hamid; Rehman, Kanwal; Kyunn, Whang Wan

doi:10.1615/critreveukaryotgeneexpr.2016015974

Cited by 24 publications

(18 citation statements)

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“…However, high level of ROS could lead to male infertility. Many studies have demonstrated that antioxidants can reduce cellular ROS accumulation [17]. Semen ROS concentration was maintained at a lower level at the beginning of normal temperature storage, which is consistent with the results of Sutovsky's study [23].…”

Section: Discussionsupporting

confidence: 88%

Hydroxytyrosol effectively improves the quality of pig sperm at room temperature

Zhang

Liu

Tian

et al. 2020

Preprint

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Background: Artificial insemination technology is the production technology used in more than 99% of the world's pig farms. Preservation of semen is mainly conducted at room temperature (17°C), during which the accumulation of reactive oxygen species (ROS). In our research, by adding different concentrations of hydroxytyrosol to the diluent during the storage of boar semen at 17°C, we compared them with the traditional diluent to study the cumulative amount of ROS, the extent of membrane damage, the sperm acrosome integrity, the activity of antioxidant enzymes, and other indicators to evaluate the effect of hydroxytyrosol on the changes of active oxygen and sperm quality during storage. After we determined the optimal amount of hydroxytyrosol in the diluent, Proteomics was used to monitor difference in sperm protein expression between the control group and the addition of 120 μmol/L hydroxytyrosol (optimum concentration) group after three days’ storage. Ultimately, we selected the control group and the addition of 120 μmol/L hydroxytyrosol group to test the effect of artificial insemination.Results: During storage of pig semen at room temperature, the sperm quality of the hydroxytyrosol-treated group was significantly improved (P < 0.05). Besides, its antioxidant capacity was also significantly improved (P < 0.05). Proteomics sequencing analysis proved that the addition of hydroxytyrosol treatment group has potential value in improving sperm cell quality. The significant increase in sow pregnancy rate and the increase in piglet birth weight also confirmed that sperm quality during storage can be of vital importance in actual production (P < 0.05).Conclusions: Based on our results, we demonstrated that the addition of hydroxytyrosol to the diluent can not only improve the quality of pig sperm, but also has an irreplaceable role in improving the efficiency of artificial insemination.

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Section: Discussionsupporting

confidence: 88%

Hydroxytyrosol effectively improves the quality of pig sperm at room temperature

Zhang

Liu

Tian

et al. 2020

Preprint

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“…2 By finding the natural resources and identification of the responsible compounds, new invention can be made for the treatment of this disease. 3 Genus Caesalpinia has been used for a very long time for the treatment of diabetes 17 but it was yet to be identified that which active agents are responsible for the cure of diabetes and by which mechanism the bioactive constituents showed activity against DM. One of the main reasons of DM is related to the damage of pancreatic β-cells.…”

Section: Ptp1b Inhibiting Capacitymentioning

confidence: 99%

“…Continued hyperglycemia due to DM causes varieties of dysfunctions and complications including renal disease, peripheral neuropathy, cardiovascular diseases, myocardial infarction, and non-healing foot ulcer. 1 There is growing evidence that reactive oxygen species (ROS) is the major cause of stimulating DM mechanisms 2,3 and responsible for the initiation of lipid peroxidation, enzyme deactivation, alteration in the collagen structure, and function. 3,4 In other words, we can say ROS have long term effects on the progression of diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…1 There is growing evidence that reactive oxygen species (ROS) is the major cause of stimulating DM mechanisms 2,3 and responsible for the initiation of lipid peroxidation, enzyme deactivation, alteration in the collagen structure, and function. 3,4 In other words, we can say ROS have long term effects on the progression of diabetes. Therefore, by using the antioxidant, the oxidative stress caused by these ROS can be relieved, thus reducing the risk of damage to the pancreas.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Screening and Content Determination of Different Species of Genus Caesalpinia belonging to Different Origin with Antidiabetic Activity

Parveen¹,

Zahra²,

Farooqi³

et al. 2017

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Aim:The main aim of the study is to investigate the phytochemical screening of C. decapetala along with the content determination of different species of genus Caesalpinia with respect to their antidiabetic activity and identification of most bioactive species belonging to different origins. Methods: To achieve our goal different species of genus Caesalpinia collected from China and Pakistan were subjected to open column chromatography, High Pressure Liquid Chromatography (HPLC), antioxidant, and antidiabetic assays for evaluation. Results: From η-BuOH fraction of C. decapetala extract, eight compounds were isolated using open column chromatography and identified as apigenin-7-rhamnoside (1), 4-O-methylepisappanol (2), caesalpinol (3), daucosterol (4), astragalin (5), kaempferol (6), quercitrin (7), and naringin (8) using Nuclear Magnetic Resonance (NMR) spectroscopy. HPLC analysis of different species of genus Caesalpinia showed that the most active antidiabetic compound 'quercitrin' was present more in C. pulcherrima followed by decreasing order in C. sappan, C.decapetala, and C. bonduc. Conclusion: The results indicated that quercitrin is the most bioactive content and C. pulcherrima is most bioactive specie of China origin from genus Caesalpinia.

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“…Though it remains unclear whether oxidative stress is a major cause or merely a consequence of mitochondrial dysfunctions associated with AD [10], supplementation with antioxidants is reported to be beneficial especially in the early stages of the disease [11]. A variety of natural antioxidants have evolved in plants, including medicinal herb, to respond to natural oxygenic atmosphere [12]. Indeed, it has been well documented that various plantderived components, including phytoestrogen, possess their ability to reduce oxidative stress [13].…”

Section: Introductionmentioning

confidence: 99%

β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways

Niu

Zhang

et al. 2018

Laboratory Investigation

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Recently, the significantly higher incidence of Alzheimer's disease (AD) in women than in men has been attributed to the loss of neuroprotective estrogen after menopause. Does phytoestrogen have the ability to protect against amyloid-β (Aβ) toxicity? The aim of this study was to evaluate hypothesis that β-ecdysterone (β-Ecd) protects SH-SY5Y cells from Aβ-induced apoptosis by separate signaling pathways involving protein kinase B (Akt) and c-Jun N-terminal kinase (JNK). Here, we demonstrate that phytoestrogen β-Ecd inhibits Aβ-triggered mitochondrial apoptotic pathway, as indicated by Bcl-2/Bax ratio elevation, cytochrome c (cyt c) release reduction, and caspase-9 inactivation. Interestingly, β-Ecd upregulates Bcl-2 expression in SH-SY5Y cells under both basal and Aβ-challenged conditions, but downregulates Bax expression only in Aβ-challenged conditions. Subsequently, Akt-dependent NF-κB activation is required for Bcl-2 upregulation, but not Bax downregulation, in response to β-Ecd, which was validated by the use of LY294002 and Bay11-7082. Notably, β-Ecd attenuates the Aβ-evoked reactive oxygen species (ROS) production, apoptosis signal-regulating kinase 1 (ASK1) phosphorylation and JNK activation without altering the basal ASK1 phosphorylation and JNK activation. ROS-scavenging by diphenyleneiodonium (DPI) abrogated the ability of β-Ecd to alter the activation of ASK1. Simultaneously, inhibition of JNK by SP600125 abolished β-Ecd-induced Bax downregulation in Aβ-challenged SH-SY5Y cells, whereas LY294002 failed to do so. Consequently, β-Ecd possesses neuroprotection by different and complementary pathways, which together promote a Bcl-2/Bax ratio. These data support our hypothesis and suggest that β-Ecd is a promising candidate for the treatment of AD.

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Recent Investigations for Discovery of Natural Antioxidants: A Comprehensive Review

Cited by 24 publications

References 0 publications

Hydroxytyrosol effectively improves the quality of pig sperm at room temperature

Hydroxytyrosol effectively improves the quality of pig sperm at room temperature

Phytochemical Screening and Content Determination of Different Species of Genus Caesalpinia belonging to Different Origin with Antidiabetic Activity

β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways

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