Recent progress in high-resolution functional MRI

Cheng, Kang

doi:10.1097/wco.0b013e3283489711

Cited by 8 publications

(4 citation statements)

References 157 publications

(122 reference statements)

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“…in Figure 1). Such concerns are discussed elsewhere (Cheng, 2011; Harel, Bolan, Turner, Ugurbil, & Yacoub, 2010; Huber et al, 2015; Nasr et al, 2016; Polimeni et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

Visual field biases for near and far stimuli in disparity selective columns in human visual cortex

Nasr

Tootell

2018

NeuroImage

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When visual objects are located in the lower visual field, human observers perceive objects to be nearer than their real physical location. Conversely, objects in the upper visual field are viewed farther than their physical location. This bias may be linked to the statistics of natural scenes, and perhaps the ecological relevance of objects in the upper and lower visual fields (Previc, 1990; Yang & Purves, 2003). However, the neural mechanisms underlying such perceptual distortions have remained unknown. To test for underlying brain mechanisms, we presented visual stimuli at different perceptual distances, while measuring high-resolution fMRI in human subjects. First, we localized disparity-selective thick stripes and thick-type columns in secondary and third visual cortical areas, respectively. Consistent with the perceptual bias, we found that the thick stripe/columns that represent the lower visual field also responded more selectively to near rather than far visual stimuli. Conversely, thick stripe/columns that represent the upper visual field show a complementary bias, i.e. selectively higher activity to far rather than near stimuli. Thus, the statistics of natural scenes may play a significant role in the organization of near- and far-selective neurons within V2 thick stripes and V3 thick-type columns.

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“…in Figure 1). Such concerns are discussed elsewhere (Cheng, 2011; Harel, Bolan, Turner, Ugurbil, & Yacoub, 2010; Huber et al, 2015; Nasr et al, 2016; Polimeni et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

Visual field biases for near and far stimuli in disparity selective columns in human visual cortex

Nasr

Tootell

2018

NeuroImage

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“…A major impediment has been the small size of the structure, which is reported as approximately 32mm 3 per hemisphere postmortem [Ranft et al, ]; in vivo estimates put the figure closer to 18.5mm 3 per hemisphere [Savitz et al, ; Savitz et al, ], but this may be an underestimation due to the difficulty of resolving the lateral and anterior boundaries of the Hb [Lawson et al, ; see also Kim et al, ]. Until recently, 3T fMRI with whole‐brain coverage and reasonable repetition times could only be reliably achieved with resolution ≥27mm 3 (i.e., 3mm isotropic voxels) [Cheng, ], making conventional fMRI voxel sizes on par with the entire volume of the Hb. Despite this limitation, several groups have attempted to study the Hb at conventional fMRI resolutions, reporting fairly consistent findings of Hb activation in response to aversive outcomes in healthy subjects [Garrison et al, ; Ide and Li, ; Li et al, ; Noonan et al, ; Schiffer et al, ; Ullsperger and von Cramon, ].…”

Section: Introductionmentioning

confidence: 99%

“…The only previously published study of Hb resting‐state functional connectivity, also at conventional fMRI resolution, reported widespread but relatively nonspecific Hb connectivity across the brain, including the dopaminergic midbrain, in a small cohort of healthy pediatric subjects [Erpelding et al, ]. However, the low spatial resolution, large tissue volumes attributed to the Hb, and substantial spatial smoothing used in these studies make signal contamination from the surrounding thalamic and ventricular areas a significant concern [Cheng, ; Turner and Geyer, ].…”

Section: Introductionmentioning

confidence: 99%

Resting-state functional connectivity of the human habenula in healthy individuals: Associations with subclinical depression

et al. 2016

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Introduction The habenula (Hb) is postulated to play a critical role in reward and aversion processing across species, including humans, and has been increasingly implicated in depression. However, technical constraints have limited in vivo investigation of the human Hb, and its function remains poorly characterized. We sought to overcome these challenges by examining the whole-brain resting-state functional connectivity of the Hb and its possible relationship to depressive symptomatology using the high-resolution WU-Minn Human Connectome Project (HCP) dataset. Methods Anatomical and resting-state functional MRI data from 50 healthy subjects with low or high subclinical depression scores (n=25 each) were analyzed. Using novel semi-automated segmentation and optimization techniques, we generated individual-specific Hb seeds and calculated whole-brain functional connectivity for the entire cohort and the contrast of high vs. low subclinical depression groups. Results In the entire cohort, the Hb exhibited significant connectivity with key brainstem structures (i.e., ventral tegmental area, substantia nigra, pons) as well as the anterior and posterior cingulate cortices, precuneus, thalamus, and sensorimotor cortex. Multiple regions showed differential Hb connectivity based on subclinical depression scores, including the amygdala, insula, and prefrontal, mid-cingulate, and entorhinal cortices. Conclusions Hb connectivity findings converged on areas associated with salience processing, sensorimotor systems, and the default mode network. We also detected substantial Hb-brainstem connectivity, consistent with prior histological and animal research. High and low subclinical depression groups exhibited differences in Hb connectivity with multiple regions previously linked to depression, suggesting the relationship between these structures as a potential target for future research and treatment.

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“…However, it takes a few seconds for the blood flow to change during brain activity, and changes in hemodynamic signals in the active brain area detectable by MRI are minuscule. The time interval from when the time point at which the brain is stimulated to the MRI signal’s peak and the limitation of calculation factors during the recording process results in a low temporal resolution (Cheng, 2011 ). EEG and MRI have the advantages of temporal resolutions down to the ns.…”

Section: Discussionmentioning

confidence: 99%

Screening Tools and Assessment Methods of Cognitive Decline Associated With Age-Related Hearing Loss: A Review

Tao

Chen

Zheng

et al. 2021

Front. Aging Neurosci.

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Strong links between hearing and cognitive function have been confirmed by a growing number of cross-sectional and longitudinal studies. Seniors with age-related hearing loss (ARHL) have a significantly higher cognitive impairment incidence than those with normal hearing. The correlation mechanism between ARHL and cognitive decline is not fully elucidated to date. However, auditory intervention for patients with ARHL may reduce the risk of cognitive decline, as early cognitive screening may improve related treatment strategies. Currently, clinical audiology examinations rarely include cognitive screening tests, partly due to the lack of objective quantitative indicators with high sensitivity and specificity. Questionnaires are currently widely used as a cognitive screening tool, but the subject’s performance may be negatively affected by hearing loss. Numerous electroencephalogram (EEG) and magnetic resonance imaging (MRI) studies analyzed brain structure and function changes in patients with ARHL. These objective electrophysiological tools can be employed to reveal the association mechanism between auditory and cognitive functions, which may also find biological markers to be more extensively applied in assessing the progression towards cognitive decline and observing the effects of rehabilitation training for patients with ARHL. In this study, we reviewed clinical manifestations, pathological changes, and causes of ARHL and discussed their cognitive function effects. Specifically, we focused on current cognitive screening tools and assessment methods and analyzed their limitations and potential integration.

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Recent progress in high-resolution functional MRI

Abstract: Real-time HR-fMRI as well as high-resolution anatomical MRI may emerge as indispensable tools for surgical planning, diagnosis of neurological diseases and targeting of deep brain stimulation.

Cited by 8 publications

References 157 publications

Visual field biases for near and far stimuli in disparity selective columns in human visual cortex

Visual field biases for near and far stimuli in disparity selective columns in human visual cortex

Resting-state functional connectivity of the human habenula in healthy individuals: Associations with subclinical depression

Screening Tools and Assessment Methods of Cognitive Decline Associated With Age-Related Hearing Loss: A Review

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