Recent progress in the two-photon fluorescent probes for metal ions

Bicolour fluorescent molecular sensors for cations: design and experimental validation

“…improved penetration, reduced toxicity, reduced autofluorescence, and minimal light scattering) drove the development of molecular probes optimized for TPA. [67][68][69] When considering ICT-based sensors, this has been pursued by binding the cation recognition site to the acceptor domain of an ICTfluorophore. Therefore, upon metal binding, rather than ICT depletion (as observed in the examples mentioned above) the polarization of the ICT excited state will increase.…”

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

“…Fortunately, fluorescence imaging has emerged as a robust technique for the direct visualization of molecular events due to its outstanding sensitivity, high temporal-spatial resolution and noninvasive nature. [25][26][27][28][29][30][31][32][33][34][35] In particular, small-molecule fluorescent probes exhibit some unique merits, including facile synthesis and modification, excellent penetration and targeting ability and satisfactory reproducibility. [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] Consequently, numerous small-molecule fluorescent probes have been explosively fabricated to explore ER as well as its corresponding active species in recent years.…”

Intelligent demethylase-driven DNAzyme sensor for highly reliable metal-ion imaging in living cells

“…Molecular probes supplement crucial tools for the visualization of specific molecular and biological processes in live cells. [1][2][3] Accordingly, live-cell imaging probes are rapidly developed by targeting tumor-relevant RNAs, 2,4-6 proteins, [7][8][9] and specific metal ions [10][11][12] and so on. Especially, these metal ions-imaging fluorescent probes occupy a significant arena for the in-depth exploration of their related cell biology researches.…”