Recent Progress on Lipid Intake and Chronic Kidney Disease

Pei, Ke; Gui, Ting; Li, Chao; Zhang, Qian; Feng, Huichao; Li, Yunlun; Wu, Jibiao; Gai, Zhibo

doi:10.1155/2020/3680397

Cited by 21 publications

(15 citation statements)

References 131 publications

(181 reference statements)

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“…Hyperlipidemia is commonly related to a high intake of diets rich in fatty acids and obesity ( 45 , 46 ). It is described that the abnormal deposition of fat in adipose tissue and in other organs, such as the liver and kidneys, can be considered an important risk in the follow-up of pathologies, including CKD ( 45 , 47 , 48 ). The presence of dyslipidemia is reported in all stages of CKD, with impairment of the glomerular filtration barrier, tubular damage, and proteinuria ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is described that the abnormal deposition of fat in adipose tissue and in other organs, such as the liver and kidneys, can be considered an important risk in the follow-up of pathologies, including CKD ( 45 , 47 , 48 ). The presence of dyslipidemia is reported in all stages of CKD, with impairment of the glomerular filtration barrier, tubular damage, and proteinuria ( 47 ). Our HFD and HFDV rats showed higher plasma levels of cholesterol and triglycerides than SD and VDD rats.…”

Section: Discussionmentioning

confidence: 99%

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The association between obesity and vitamin D deficiency modifies the progression of kidney disease after ischemia/reperfusion injury

et al. 2022

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Acute kidney injury (AKI) alters renal hemodynamics, leading to tubular injury, activating pathways of inflammation, proliferation, and cell death. The initial damage caused to renal tissue after an ischemia/reperfusion (I/R) injury exerts an important role in the pathogenesis of the course of AKI, as well as in the predisposition to chronic kidney disease. Vitamin D deficiency has been considered a risk factor for kidney disease and it is associated with tubulointerstitial damage, contributing to the progression of kidney disease. Obesity is directly related to diabetes mellitus and hypertension, the main metabolic disorders responsible for the progression of kidney disease. Furthermore, the expansion of adipose tissue is described as an important factor for increased secretion of pro-inflammatory cytokines and their respective influence on the progression of kidney disease. We aimed to investigate the influence of vitamin D deficiency and obesity on the progression of renal disease in a murine model of renal I/R. Male Wistar rats underwent renal I/R surgery on day 45 and followed until day 90 of the protocol. We allocated the animals to four groups according to each diet received: standard (SD), vitamin D-depleted (VDD), high fat (HFD), or high fat vitamin D-depleted (HFDV). At the end of 90 days, we observed almost undetectable levels of vitamin D in the VDD and HFDV groups. In addition, HFD and HFDV groups presented alterations in the anthropometric and metabolic profile. The combination of vitamin D deficiency and obesity contributed to alterations of functional and hemodynamic parameters observed in the HFDV group. Moreover, this combination favored the exacerbation of the inflammatory process and the renal expression of extracellular matrix proteins and phenotypic alteration markers, resulting in an enlargement of the tubulointerstitial compartment. All these changes were associated with an increased renal expression of transforming growth factor β and reduced expression of the vitamin D receptor. Our results show that the synergistic effect of obesity and vitamin D deficiency exacerbated the hemodynamic and morphological changes present in the evolution of renal disease induced by I/R.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The association between obesity and vitamin D deficiency modifies the progression of kidney disease after ischemia/reperfusion injury

et al. 2022

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“…Hyperlipidemia is a common symptom in DM. Continuous renal filtration of lipids in rats with DM leads to chronic kidney injury, albuminuria, and glomerulosclerosis [ 45 ]. In agreement with our findings, a study reported that treatment with L-lysine significantly alleviated diabetic dyslipidemia [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

L‐Lysine Ameliorates Diabetic Nephropathy in Rats with Streptozotocin‐Induced Diabetes Mellitus

Jozi

Kheiripour

Taheri

et al. 2022

BioMed Research International

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Introduction. Diabetic nephropathy is one of the leading causes of end-stage renal disease worldwide. Uncontrolled hyperglycemia and subsequent production of glycation end-products activate the paths which lead to diabetic nephropathy. The aim of this study was to assess the effects of L-lysine on antioxidant capacity, biochemical factors, kidney function, HSP70 level, and the expression of the TGFβ, VEGF, and RAGE genes in rats with streptozocin-induced diabetes mellitus. Methods. Thirty-two male Wistar rats were randomly allocated to four eight-rat groups, namely, a healthy group, a diabetic group treated with vehicle (DM + vehicle), a diabetic group treated with L-lysine (DM + Lys), and a healthy group treated with L-lysine (healthy + Lys). Rats in the DM + Lys and the healthy + Lys groups were treated with L-lysine 0.15%. The levels of fasting blood glucose, insulin, HbA1C, advanced glycation end-products (AGEs), lipid profile, serum creatinine, blood urea nitrogen, glomerular filtration rate, urine microalbumin, oxidative stress parameters, kidney histology and morphology, and TGFβ, VEGF, and RAGE gene expressions were assessed. Findings. An eight-week treatment with L-lysine significantly reduced the levels of fasting blood glucose, AGEs, kidney function parameters, oxidative stress parameters, lipid profile, and the TGFβ, VEGF, and RAGE gene expression and significantly increased the levels of serum insulin and tissue HSP70. Conclusion. Treatment with L-lysine seems to slow down the progression of diabetic nephropathy.

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“…Some studies on protein sources suggest that fish proteins do not affect albuminuria as much as proteins from meat and meat products [ 28 , 46 ], and the same could be true for fat. Several studies on omega-3 polyunsaturated FA supplementation report beneficial effects on urinary albumin excretion and kidney function in patients with and without diabetes [ 47 , 48 , 49 , 50 ], possibly by decreasing inflammation and endothelial dysfunction, as well as reducing hypertension and dyslipidemia [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Animal Fat Intake Is Associated with Albuminuria in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome

et al. 2021

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Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are associated with chronic kidney disease (CKD). Diet could play a predisposing role in the development of increased albuminuria in patients with NAFLD and MetS; however, published evidence is still limited. The aim of this cross-sectional analysis was to assess whether dietary fats are associated with changes in urinary albumin-to-creatinine ratio (UACR) in 146 patients aged 40–60-years with NAFLD and MetS. Dietary data were collected by food frequency questionnaire; UACR was measured in a single first morning void. Sources and types of dietary fats used in the analysis were total fat, fats from animal and vegetable sources, saturated, monounsaturated, polyunsaturated, and trans fats. One-way analysis of variance was performed to assess differences in dietary fats intakes across stages of UACR. The association between dietary fats and UACR was assessed by Pearson’s correlation coefficient and multivariable linear regression. Patients with increased UACR showed a worse cardiometabolic profile and higher intakes of animal fat, as compared to patients with normal levels of albuminuria. Animal fat intake was associated with mean UACR, independent of potential covariates.

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Recent Progress on Lipid Intake and Chronic Kidney Disease

Cited by 21 publications

References 131 publications

The association between obesity and vitamin D deficiency modifies the progression of kidney disease after ischemia/reperfusion injury

The association between obesity and vitamin D deficiency modifies the progression of kidney disease after ischemia/reperfusion injury

L‐Lysine Ameliorates Diabetic Nephropathy in Rats with Streptozotocin‐Induced Diabetes Mellitus

Animal Fat Intake Is Associated with Albuminuria in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome

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