Recent strategies to develop pH-sensitive injectable hydrogels

Abstract

“Smart” biomaterials that are responsive to pathological abnormalities are an appealing class of therapeutic platform for the development of personalized medications. Development of such therapeutic platform requires novel techniques that...

Recent advances in injectable hydrogel therapies for periodontitis

“…pH-Sensitive hydrogels include acidic, basic, and amphoteric polymers that respond to pH changes. 112 However, when compared with normal physiological conditions (pH 7.2–7.4), inflammatory conditions (pH < 5.0) are lower. 113,114 For this reason, pH-responsive acidic hydrogels have been extensively examined; such hydrogels may lessen the harmful side effects elicited by their non-specific distribution by providing regulated drug release kinetics via pH-dependent swelling or collapse behaviors.…”

Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels

“…pH-responsive "smart" hydrogels typically consist of polymeric materials containing acidic or basic residues that can undergo specific changes in their physicochemical properties when exposed to varying environmental pH levels [ 123 ]. Incorporating polymers into the pH-responsive hydrogel system to create an interpenetrating network can enhance its structural integrity, resulting in superior mechanical properties, improved rheological behavior, heightened sensitivity to reversible pH-induced swelling and de-swelling, and the development of a more porous structure.…”

State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems

“…Advantages Disadvantages pH Response to change in environmental pH Controlled release of therapeutic drugs Minimal harm [38] Poor reusability [39] Susceptible to rupture [40] Temperature Easy to formulate Deliver both hydrophilic and hydrophobic drugs [41] Low sensitivity and Poor reusability [39] Light Easily controlled and triggered by light Precise and targeted drug delivery [42,43] Ultraviolet light may have potential toxicity concerns. Side-reactivity and challenges in optimizing release mechanisms [44] Electric Field…”