Recent trends on burn wound care: hydrogel dressings and scaffolds

Yao, Yingxia; Zhang, Andi; Yuan, Cong-Shan; Chen, Xiguang; Liu, Ya

doi:10.1039/d1bm00411e

Cited by 118 publications

(67 citation statements)

References 140 publications

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“…Additionally, they exhibited good antimicrobial activity against E. coli and MRSA once loaded with silver nanoparticles. Although numerous dressings are already commercially available, there is a great need for the design and synthesis of novel wound-care materials to address the increasing number of burn injuries [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Crosslinked Agar/Acrylic Acid Hydrogels with Antimicrobial Properties

Pino‐Ramos

Duarte-Peña

Bucio

2021

Gels

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Hydrogels are three-dimensional soft polymeric materials that can entrap huge amounts of water. They are widely attractive in the biomedicine area because of their outstanding applications such as biosensors, drug delivery vectors, or matrices for cell scaffolds. Generally, the low mechanical strength and fragile structure of the hydrogels limit their feasibility, but this is not the case. In this work, acrylic acid–agar hydrogels with excellent mechanical properties were synthesized using gamma radiation as a crosslinking promoter. The obtained hydrogels exhibited a water absorption capacity up to 6000% in weight without breaking and keeping their shape; additionally, they showed a noticeable adhesion to the skin. The synthesized materials were characterized by infrared spectroscopy (FTIR-ATR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and mechanical testing. Additionally, their water uptake capacity and critical pH were studied. Net(Agar/AAc) hydrogel exhibited a noticeable capacity to load silver nanoparticles (AgNPs), which endowed it with antimicrobial activity that was demonstrated when challenged against Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) on in vitro conditions.

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Section: Introductionmentioning

confidence: 99%

Highly Crosslinked Agar/Acrylic Acid Hydrogels with Antimicrobial Properties

Pino‐Ramos

Duarte-Peña

Bucio

2021

Gels

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“…Hydrogel dressings can be divided, according to the type of polymer used, into natural and synthetic ones or, depending on the substances added, to inert and active [ 34 ]. Natural hydrogels are based on chitosan, cellulose, alginate, dextran, or hyaluronic acid [ 35 ]. Hydrogels can be synthetized from polymeric chains of polyacrylamide, polyethylene oxide, or polyvinylpyrrolidone (PVP) [ 36 ].…”

Section: Types Of Hydrogelsmentioning

confidence: 99%

Hydrogels in Burn Wound Management—A Review

Surowiecka¹,

Strużyna

Winiarska³

et al. 2022

Gels

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Inert hydrogels are of a great importance in burn first aid. Hydrogel dressings may be an alternative to cooling burn wounds with streaming water, especially in cases of mass casualty events, lack of clean water, hypothermia, or large extent of burns. Hydrogels that contain mostly water evacuate the heat cumulating in the skin by evaporation. They not only cool the burn wound, but also reduce pain and protect the wound area from contamination and further injuries. Hydrogels are ideally used during the first hours after injury, but as they do not have antimicrobial properties per se, they might not prevent wound infection. The hydrogel matrix enables incorporating active substances into the dressing. The active forms may contain ammonium salts, nanocrystal silver, zinc, growth factor, cytokines, or cells, as well as natural agents, such as honey or herbs. Active dressings may have antimicrobial activity or stimulate wound healing. Numerous experiments on animal models proved their safety and efficiency. Hydrogels are a new dressing type that are still in development.

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“…Its 3D structure and biophysical properties (shape, mechanical strength and permeability) are similar to naturally sourced ECM [ 47 ]. It is currently extensively used in the medical field with 3D bioprinting, including the repair of skin wounds [ 48 , 49 , 50 ], bone damage [ 51 , 52 , 53 ], cartilage injury [ 54 , 55 , 56 ] and cardiac rehabilitation [ 57 , 58 , 59 , 60 ].…”

Section: The Bioinks Of 3d Bioprintingmentioning

confidence: 99%

Application of 3D Bioprinting in Urology

et al. 2022

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Tissue engineering is an emerging field to create functional tissue components and whole organs. The structural and functional defects caused by congenital malformation, trauma, inflammation or tumor are still the major clinical challenges facing modern urology, and the current treatment has not achieved the expected results. Recently, 3D bioprinting has gained attention for its ability to create highly specialized tissue models using biological materials, bridging the gap between artificially engineered and natural tissue structures. This paper reviews the research progress, application prospects and current challenges of 3D bioprinting in urology tissue engineering.

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Recent trends on burn wound care: hydrogel dressings and scaffolds

Abstract: Biomaterial -based therapy in burn wound care and the roles and advantages of hydrogels.

Cited by 118 publications

References 140 publications

Highly Crosslinked Agar/Acrylic Acid Hydrogels with Antimicrobial Properties

Highly Crosslinked Agar/Acrylic Acid Hydrogels with Antimicrobial Properties

Hydrogels in Burn Wound Management—A Review

Application of 3D Bioprinting in Urology

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