Receptor-mediated endocytosis by human Kupffer cells

Toth, Carol A.; Rapoza, Alan; Kowal, Anne; Steele, Glenn; Thomas, Peter

doi:10.1042/bst0161027

Cited by 14 publications

(11 citation statements)

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“…C-reactive protein appears as an acute-phase reactant in response to bacterial infections; it binds to pneumococcal cell walls and is recognized by Clq, activating the classic complement pathway (93,94). CEA and its gene family member nonspecific cross-reacting antigen (NCA) are recognized by a receptor on the surface of the Kupffer cell that is described in some detail below (95). Both CEA and NCA bind with high avidity to Escherichia coli and various strains of Salmonella, suggesting that these molecules also could function as potential bacterial opsonins (96).…”

Section: Clearance Of Microorganismsmentioning

confidence: 99%

“…This area of CEA has a very high degree of sequence homology with NCA (114). Both rodent and human Kupffer cells have been shown to have similar CEA-binding proteins (95). CEA taken into the Kupffer cell is minimally modified by the removal of sialic acid and is exocytosed back into the sinusoid where it is taken up by the asialoglycoprotein receptor on the hepatocyte (115).…”

Section: Carcinoembryonic Antigenmentioning

confidence: 99%

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Liver Endocytosis and Kupffer Cells

1992

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Section: Clearance Of Microorganismsmentioning

confidence: 99%

Section: Carcinoembryonic Antigenmentioning

confidence: 99%

Liver Endocytosis and Kupffer Cells

1992

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“…Kupffer cells lining the sinusoids take up CEA via specific receptors and it is transferred to the hepatocytes, where it is degraded. During this process CEA can be detected on the surface of both the Kupffer cells and the hepatocytes [16,17]. The demonstration that CEA can function as a CAM, binding both CEA and NCA bearing cells, raises the possibility that its expression by cells lining the liver sinusoids results in the establishment of a kind of homing receptor which causes the circulating CEA positive tumor cells to stop in the liver.…”

Section: Overexpression Of Carcinoembryonic Antigen In Colorectal Carmentioning

confidence: 99%

Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease

Johnson¹

1991

Cancer Metast Rev

135

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Cell adhesion molecules (CAMs) of the immunoglobulin supergene family may play important roles in tumorigenesis and the development of metastatic disease. In a variety of human malignancies, tumor progression has been observed to be associated with changes in CAM expression. An early event in colorectal tumorigenesis appears to be the down regulation of a normally expressed CAM, DCC. Over-expression of a second CAM, carcinoembryonic antigen, is associated with colorectal tumors which have a high risk for metastasis development. Several tumors, including Wilms tumors and neuroblastoma, have been found to express a developmentally regulated form of NCAM which inhibits a variety of cell-cell interactions. Malignant cells not only show aberrations in the expression of their CAMS and thus their normal cell-cell interactions, but establish new adhesive interactions. The development of metastatic potential in cutaneous melanoma is associated with the de novo expression of two CAMs, one of which is ICAM-1, a molecule mediating adhesion between the tumor cells and leukocytes.

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“…Kupffer cells in the liver and alveolar macrophages in the lung are known to bind CEA in the circulation through specialised receptors (Toth et al, 1982;. Human (Toth et al, 1989) and rodent (Toth et al, 1985) Kupffer cells endocytose CEA, remove sialic acid, and secrete asialo CEA which is immediately bound and metabolised by the hepatocyte. In contrast, alveolar macrophages endocytose CEA and degrade it without releasing immunoreactive epitopes (Toth et al, 1989a).…”

mentioning

confidence: 99%