Receptor-mediated endocytosis of antibody-opsonized liposomes by tumor cells.

Leserman, Lee; Weinstein, John N.; Blumenthal, Robert; Terry, William D.

doi:10.1073/pnas.77.7.4089

Cited by 73 publications

(31 citation statements)

References 20 publications

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“…In several model systems, ligand-bearing liposomes have been used as probes of lymphoid cell surface molecules (1)(2)(3)(4)(5). We have used the fluorophore carboxyfluorescein (CF) (6) and the folic acid analogue methotrexate (Mtx) encapsulated in liposomes in several such studies (3, 4, 7 . The number of bound liposomes can be measured by fluorescence.…”

Section: Lated T and B Cellsmentioning

confidence: 99%

Differential endocytosis of T and B lymphocyte surface molecules evaluated with antibody-bearing fluorescent liposomes containing methotrexate.

Machy¹,

Barbet²,

Leserman³

1982

Proc. Natl. Acad. Sci. U.S.A.

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Antibody-bearing fluorescent liposomes containing methotrexate became bound to cells expressing determinants recognized by the antibody. The number ofbound liposomes could be evaluated by fluorometry, and the internalization of liposomes was evaluated by the methotrexate-mediated inhibition of radiolabeled deoxyuridine incorporation. The effect of methotrexate transferred from the liposomes into the cells was a function not of the number of liposomes bound but of the nature of the cells and of the target molecules. Liposomes bearing antibodies with specificity for the H-2Kor Mr 94,000 and 180,000 molecules were much more effective at drug delivery into T than B cells, even though these determinants were expressed by both cell types. B cells were more sensitive to the effect of methotrexate in anti-H-2

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Section: Lated T and B Cellsmentioning

confidence: 99%

Differential endocytosis of T and B lymphocyte surface molecules evaluated with antibody-bearing fluorescent liposomes containing methotrexate.

Machy¹,

Barbet²,

Leserman³

1982

Proc. Natl. Acad. Sci. U.S.A.

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“…Due to limitations of passive targeting, nanoparticles are modified by conjugating targeting species to increase their affinity for specific cell binding to capitalize their full potential benefit. [475] Although this approach has been proposed about 40 years ago, [476] ligand-decorated nanoparticles have recently paved their way to clinical trials. [477] Increase in affinity and its consequent specific cell binding is achieved by NPs equipped with targeting species which are complementary to unique receptors on target cells.…”

Section: Active Targetingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

204

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…Like the A-chains, RIPS do not bind to cells, have a low intrinsic toxicity, and can acquire toxicity upon conjugation to con A [3], to monoclonal anti-Thy 1.1 antibody [5], and to the Fab' fragment of IgG [a], or by inclusion into liposomes [7]. Liposomes have the great advantage of carrying a larger amount of unmodified protein; however, they are internalized into cells by endocytotic processes, and consequently most of the macromolecules they deliver are degradated [8].…”

Section: Toxinmentioning

confidence: 99%

Cytotoxicity acquired by ribosome‐inactivating proteins carried by reconstituted Sendai virus envelopes

et al. 1983

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Association of the ribosome‐inactivating proteins (RIPs): pokeweed antiviral protein (PAP), gelonin, Momordica charantia inhibitor (MCI), with reconstituted Sendai virus envelopes (RSVE) was obtained without detectable loss of activities either of RIPs or of viral envelope glycoproteins. RIPs are inactive towards intact cells, but, once encapsulated in RSVE, they become cytotoxic. The concentration of RSVE‐associated PAP, which causes 50% inhibition of protein synthesis by Friend erythroleukemic cells, is 0.5 ng/ml. Substances capable to inhibit the viral activities block the acquired cytotoxicity of RIPs associated to RSVE.

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Receptor-mediated endocytosis of antibody-opsonized liposomes by tumor cells.

Cited by 73 publications

References 20 publications

Differential endocytosis of T and B lymphocyte surface molecules evaluated with antibody-bearing fluorescent liposomes containing methotrexate.

Differential endocytosis of T and B lymphocyte surface molecules evaluated with antibody-bearing fluorescent liposomes containing methotrexate.

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Cytotoxicity acquired by ribosome‐inactivating proteins carried by reconstituted Sendai virus envelopes

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