Receptors for human immunoglobulin on acute myeloid leukaemic leucocytes

Ridway, J C; Taylor, Gillian; Freeman, Clara; Harris, Rodney

doi:10.1038/bjc.1976.177

Br J Cancer

1976

DOI: 10.1038/bjc.1976.177

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Receptors for human immunoglobulin on acute myeloid leukaemic leucocytes

J C Ridway¹,

Gillian Taylor²,

Clara Freeman³

et al.

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1977

1979

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Cited by 7 publications

(1 citation statement)

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“…9 and 15). However, non-related immune complexes can bind to cells from a non-lymphoid murine tumour (I), and to human acute myeloid leukaemic leucocytes (7). Further, non-specifically bound IgG can be eluted from human solid tumours ( 14).…”

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Fcσ RECEPTORS AND IgG ASSOCIATED WITH HUMAN MALIGNANT TUMOURS

Wesenberg

1978

Acta Pathologica Microbiologica Scandinavica Section C Immunolo

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Thirteen solid tumours were tested for Feσ receptors (FcR) using tissue sections and sheep erythrocytes sensitized with rabbit antibodies as indicator cells. No alteration was found in FcR activity (FcRA) between untreated tissue and tissue homogenized for 2 min or less. More extensive homogenization abolished the FcRA. Tissues homogenized for 1 min were washed at 4° C and eluted at 37, 45 and 56° C. The FcRA was not altered after elution at 37 and 45° C. However, elution at 56° C abolished the activity indicating that the FcR were either eluted or destroyed. Tumours which showed a diffuse pattern of FcRA and no non‐specifically bound IgG displayed an inverse relationship between the FcRA and the eluted IgG. Such relationship was not found with tumours containing non‐specifically bound IgG.

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mentioning

confidence: 99%

Fcσ RECEPTORS AND IgG ASSOCIATED WITH HUMAN MALIGNANT TUMOURS

Wesenberg

1978

Acta Pathologica Microbiologica Scandinavica Section C Immunolo

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Surface immunoglobulins and protease inhibitors of human acute leukemia blasts

Cotropia

Gutterman

Hersh

et al. 1977

Intl Journal of Cancer

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Cell-surface proteins of human leukemic blasts were studied by direct immunofluorescence (DIF), low pH elution and immunodiffusion (ID). Among A M L blasts from 21 patients, the average proportions of blasts positive for IgG, IgM, and IgA were 60%, 9%, and 9% respectively. I n contrast, blasts from four CML patients in blast crisis and 14 A L L patients had surface IgG, IgM, and IgA values of 14%, 9%, and 7% respectively for the former group and 1.4%, 1.1%. and 0.8% respectively for the latter group. Blasts from 20 leukemic cell preparations were eluted at pH 2. The Fab reaction product is incapable of interacting with either complement or Fc receptors. Therefore, such proteolytic activity may protect the leukemic blasts from lysis by complement-dependent o r antibody-dependent cell-mediated cytotoxic mechanisms.

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Fc receptors on myeloid leukaemic cells: Comparison between assays of rosette-forming cells

Ridway

Taylor

Harris

1979

Journal of Immunological Methods

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Receptors for human immunoglobulin on acute myeloid leukaemic leucocytes

Cited by 7 publications

References 18 publications

Fcσ RECEPTORS AND IgG ASSOCIATED WITH HUMAN MALIGNANT TUMOURS

Fcσ RECEPTORS AND IgG ASSOCIATED WITH HUMAN MALIGNANT TUMOURS

Surface immunoglobulins and protease inhibitors of human acute leukemia blasts

Fc receptors on myeloid leukaemic cells: Comparison between assays of rosette-forming cells

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