Reciprocal deterioration of visual and auditory hallucinations in schizophrenia presents V-shaped cognition impairment and widespread reduction in brain gray matter-A pilot study

Zhuo, Chuanjun; Chen, Min; Xu, Yong; Jiang, Deguo; Chen, Ce; Ma, Xiaoyan; Li, Ranli; Sun, Yun; Li, Qianchen; Zhou, Chunhua; Lin, Xiaodong

doi:10.1016/j.jocn.2020.07.054

Cited by 7 publications

(5 citation statements)

References 36 publications

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“…We also observe that facial expressivity was decreased as subjects endorsed greater positive symptoms of hallucinations, delusions, and paranoid ideation. This finding is consistent with evidence that social and cognitive impairment, which falls into the negative symptom cluster, mechanistically relates to neurodegeneration that also impacts visual and auditory hallucinations (Bersani et al, 2013;Jenkins et al, 2018;Zhuo et al, 2020).…”

Section: -Discussionsupporting

confidence: 89%

Facial and vocal markers of schizophrenia measured using remote smartphone assessments

Galatzer‐Levy

Abbas

Koesmahargyo

et al. 2020

Preprint

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BackgroundMachine learning-based facial and vocal measurements have demonstrated relationships with schizophrenia diagnosis and severity. Here, we determine their accuracy of when acquired through automated assessments conducted remotely through smartphones. Demonstrating utility and validity of remote and automated assessments conducted outside of controlled experimental settings can facilitate scaling such measurement tools to aid in risk assessment and tracking of treatment response in difficult to engage populations.MethodsMeasurements of facial and vocal characteristics including facial expressivity, vocal acoustics, and speech prevalence were assessed in 20 schizophrenia patients over the course of 2 weeks in response to two classes of prompts previously utilized in experimental laboratory assessments: evoked prompts, where subjects are guided to produce specific facial expressions and phonations, and spontaneous prompts, where subjects are presented stimuli in the form of emotionally evocative imagery and asked to freely respond. Facial and vocal measurements were assessed in relation to schizophrenia symptom severity using the Positive and Negative Syndrome Scale.ResultsVocal markers including speech prevalence, vocal jitter, fundamental frequency, and vocal intensity demonstrated specificity as markers of negative symptom severity while measurement of facial expressivity demonstrated itself as a robust marker of overall schizophrenia severity.ConclusionEstablished facial and vocal measurements, collected remotely in schizophrenia patients via smartphones in response to automated task prompts, demonstrated accuracy as markers of schizophrenia severity. Clinical implications are discussed.

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Section: -Discussionsupporting

confidence: 89%

Facial and vocal markers of schizophrenia measured using remote smartphone assessments

Galatzer‐Levy

Abbas

Koesmahargyo

et al. 2020

Preprint

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“…For instance, schizophrenia patients with AVH showed increased ALFF in the bilateral temporal role and parahippocampus gyrus, while decreased ALFF in the parietal, occipital, and cingulate cortex. In the structural domain, smaller gray matter volume (GMV) with AVH in schizophrenia patients, as measured with voxel-based morphometry (VBM), have been identified in a wide range of brain regions, including the prefrontal, parietal, temporal, and occipital cortex ( Dean et al, 2020 ; Zhuo et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

rTMS Induces Brain Functional and Structural Alternations in Schizophrenia Patient With Auditory Verbal Hallucination

et al. 2021

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BackgroundLow-frequency transcranial magnetic stimulation (rTMS) over the left temporoparietal cortex reduces the auditory verbal hallucination (AVH) in schizophrenia. However, the underlying neural basis of the rTMS treatment effect for schizophrenia remains not well understood. This study investigates the rTMS induced brain functional and structural alternations and their associations with clinical as well as neurocognitive profiles in schizophrenia patients with AVH.MethodsThirty schizophrenia patients with AVH and thirty-three matched healthy controls were enrolled. The patients were administered by 15 days of 1 Hz rTMS delivering to the left temporoparietal junction (TPJ) area. Clinical symptoms and neurocognitive measurements were assessed at pre- and post-rTMS treatment. The functional (amplitude of low-frequency fluctuation, ALFF) and structural (gray matter volume, GMV) alternations were compared, and they were then used to related to the clinical and neurocognitive measurements after rTMS treatment.ResultsThe results showed that the positive symptoms, including AVH, were relieved, and certain neurocognitive measurements, including visual learning (VisLearn) and verbal learning (VerbLearn), were improved after the rTMS treatment in the patient group. Furthermore, the rTMS treatment induced brain functional and structural alternations in patients, such as enhanced ALFF in the left superior frontal gyrus and larger GMV in the right inferior temporal cortex. The baseline ALFF and GMV values in certain brain areas (e.g., the inferior parietal lobule and superior temporal gyrus) could be associated with the clinical symptoms (e.g., positive symptoms) and neurocognitive performances (e.g., VerbLearn and VisLearn) after rTMS treatment in patients.ConclusionThe low-frequency rTMS over the left TPJ area is an efficacious treatment for schizophrenia patients with AVH and could selectively modulate the neural basis underlying psychiatric symptoms and neurocognitive domains in schizophrenia.

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“…It was found that patients with schizophrenia showed signi cantly higher theta power in the SG paradigm than healthy controls, similar to the conclusions mentioned in the literature [5] In many patients with schizophrenia, various evoked potential patterns in vitro and in vivo suggested that stimuli evoked early theta frequency oscillations. Previous studies have reported dysfunction in the left temporal region involved in speech classi cation in schizophrenia and reduced gray matter volume in the occipital, parietal, frontal, and temporal cortex in schizophrenia compared with healthy controls [7,15]. Therefore, we analyzed each of the six brain regions, and the results showed that schizophrenic patients showed higher theta oscillations in the whole brain.…”

Section: Abnormal Theta In Schizophrenia In Sg and Mmnmentioning

confidence: 94%

“…Some studies have found that theta activity in both temporal lobes increased in untreated schizophrenic patients [6]. Schizophrenic patients showed dysfunction in the occipital lobe, parietal lobe and temporal lobe cortex in the speech classi cation test [7]. The defect in auditory information processing in schizophrenia was due to the reduction in inhibition caused by the destruction of the inhibition mechanism needed to suppress redundant sound input.…”

Section: Introductionmentioning

confidence: 99%

Abnormal theta oscillation in schizophrenic patients under auditory stimulation: a comparative study

Zhang

Wei

Wan

2023

Preprint

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Background: There was growing evidences that theta (4-7Hz) power was highly likely to be an indicator of cognitive deficits in schizophrenia. And auditory information processing deficits in schizophrenia were reduced inhibition due to the disruption of the inhibitory mechanisms required to suppress redundant acoustic input. Further assuming that this inhibition was mainly evident in the theta band activity and reflected in the different brain regions. Method: We chose to use the auditory paradigms to study the change of the theta band power in different brain regions in patients with patients using frequency domain analysis. Results: The results showed that the sounds always induced abnormal elevation of theta oscillations, and when the frequency of sound stimulation was different, the striking elevation of the induced theta oscillations was reflected in temporal, parietal and central regions. While compared to the other frequencies, the abnormality of theta oscillations had specificity and stability. Conclusion: This suggested that theta oscillations could serve as a biomarker in schizophrenia research. Future studies in the corresponding brain regions could also provide reference for the selection of the frequency and location for non-invasive treatment in patients with schizophrenia.

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Reciprocal deterioration of visual and auditory hallucinations in schizophrenia presents V-shaped cognition impairment and widespread reduction in brain gray matter-A pilot study

Cited by 7 publications

References 36 publications

Facial and vocal markers of schizophrenia measured using remote smartphone assessments

Facial and vocal markers of schizophrenia measured using remote smartphone assessments

rTMS Induces Brain Functional and Structural Alternations in Schizophrenia Patient With Auditory Verbal Hallucination

Abnormal theta oscillation in schizophrenic patients under auditory stimulation: a comparative study

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