Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge

Karaca, Kemal; Bowen, Richard A.; Austgen, Laura E.; Teehee, Max; Siger, L.; Grosenbaugh, Deborah A.; Loosemore, L.; Audonnet, Jean-Christophe; Nordgren, Robert; Minke, J.M.

doi:10.1016/j.vaccine.2005.02.020

Cited by 49 publications

(25 citation statements)

References 16 publications

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“…6320), and were not seen in any other group. In mammalian hosts and poultry, recombinant vaccines created from Avipox genera, such as fowlpox and canarypox, have been considered safe and immunogenic (Taylor et al 1988(Taylor et al , 1991, and the WNV canarypox vaccine has been shown to be safe and effective in horses, dogs, and cats (Minke et al 2004, Karaca et al 2005. The lesions noted at the vaccine inoculation sites in our study may have been due to replication of the recombinant canarypox virus, and we recommend that the Merial vaccine be assessed carefully before its use in other avian species, especially passerines.…”

Section: Efficacy Of Wnv Vaccines In Western Scrub-jaysmentioning

confidence: 99%

Efficacy of Three Vaccines in Protecting Western Scrub-Jays (Aphelocoma californica) from Experimental Infection with West Nile Virus: Implications for Vaccination of Island Scrub-Jays (Aphelocoma insularis)

Wheeler

Langevin

Woods

et al. 2011

Vector-Borne and Zoonotic Diseases

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The devastating effect of West Nile virus (WNV) on the avifauna of North America has led zoo managers and conservationists to attempt to protect vulnerable species through vaccination. The Island Scrub-Jay (Aphelocoma insularis) is one such species, being a corvid with a highly restricted insular range. Herein, we used congeneric Western Scrub-Jays (Aphelocoma californica) to test the efficacy of three WNV vaccines in protecting jays from an experimental challenge with WNV: (1) the Fort Dodge West Nile-Innovator Ò DNA equine vaccine, (2) an experimental DNA plasmid vaccine, pCBWN, and (3) the Merial Recombitek Ò equine vaccine. Vaccine efficacy after challenge was compared with naïve and nonvaccinated positive controls and a group of naturally immune jays. Overall, vaccination lowered peak viremia compared with nonvaccinated positive controls, but some WNV-related pathology persisted and the viremia was sufficient to possibly infect susceptible vector mosquitoes. The Fort Dodge West Nile-Innovator DNA equine vaccine and the pCBWN vaccine provided humoral immune priming and limited side effects. Five of the six birds vaccinated with the Merial Recombitek vaccine, including a vaccinated, non-WNV challenged control, developed extensive necrotic lesions in the pectoral muscle at the vaccine inoculation sites, which were attributed to the Merial vaccine. In light of the well-documented devastating effects of high morbidity and mortality associated with WNV infection in corvids, vaccination of Island Scrub-Jays with either the Fort Dodge West Nile-Innovator DNA vaccine or the pCBWN vaccine may increase the numbers of birds that would survive an epizootic should WNV become established on Santa Cruz Island.

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Section: Efficacy Of Wnv Vaccines In Western Scrub-jaysmentioning

confidence: 99%

Efficacy of Three Vaccines in Protecting Western Scrub-Jays (Aphelocoma californica) from Experimental Infection with West Nile Virus: Implications for Vaccination of Island Scrub-Jays (Aphelocoma insularis)

Wheeler

Langevin

Woods

et al. 2011

Vector-Borne and Zoonotic Diseases

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“…A number of other live, attenuated recombinant virus vector vaccines have also been developed. A veterinary vaccine using a canarypox-based vector expressing WNV prM and Env has demonstrated efficacy in preventing viremia across several animal species including horses, cats and dogs [77,78]. An HIV-based lentiviral vector expressing the WNV Env protein was shown to induce a protective immune response in mice within 1 week of a single immunization [79].…”

Section: Vaccines In Pre-clinical Developmentmentioning

confidence: 99%

Current trends in West Nile virus vaccine development

Amanna

Slifka

2014

Expert Review of Vaccines

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West Nile virus (WNV) is a mosquito-borne flavivirus that has become endemic in the United States. From 1999-2012, there have been 37,088 reported cases of WNV and 1,549 deaths, resulting in a 4.2% case-fatality rate. Despite development of effective WNV vaccines for horses, there is no vaccine to prevent human WNV infection. Several vaccines have been tested in preclinical studies and to date there have been 8 clinical trials, with promising results in terms of safety and induction of antiviral immunity. Although mass vaccination is unlikely to be cost-effective, implementation of a targeted vaccine program may be feasible if a safe and effective vaccine can be brought to market. Further evaluation of new and advanced vaccine candidates is strongly encouraged.

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“…Other examples include the use of a canarypox-based recombinant containing the PrM and E genes of the West Nile Virus (WNV) to induce protection in cats and dogs. This study resulted in the expression of the WNV genes and the induction of protective immunity [65]. The orf virus has been used to generate protective immunity against CSV using the E2 gene [66] and pseudorabies in pigs [67].…”

Section: Other Virus Vectorsmentioning

confidence: 99%

An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines

Dong

Zarlenga

Ren

2014

Journal of Immunology Research

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Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals.

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Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge

Cited by 49 publications

References 16 publications

Efficacy of Three Vaccines in Protecting Western Scrub-Jays (Aphelocoma californica) from Experimental Infection with West Nile Virus: Implications for Vaccination of Island Scrub-Jays (Aphelocoma insularis)

Efficacy of Three Vaccines in Protecting Western Scrub-Jays (Aphelocoma californica) from Experimental Infection with West Nile Virus: Implications for Vaccination of Island Scrub-Jays (Aphelocoma insularis)

Current trends in West Nile virus vaccine development

An Overview of Live Attenuated Recombinant Pseudorabies Viruses for Use as Novel Vaccines

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