Reconstruction of posttraumatic and postoperative defects of lower jaw

Котельников, Г. П.; Колсанов, А В; Щербовских, А Е; Nikolaenko, A. N.; Приходько, С А; Popov, N; Khassan, M A

doi:10.17116/hirurgia2017769-72

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Одна из наиболее важных и значимых задач в практической деятельности травматологов-ортопедов -заполнение костных дефектов различной этиологии [1,2]. На сегодняшний день традиционно для костной пластики костных дефектов используют аутогенную кость, которая в настоящее время остается золотым стандартом замещения костных изъянов разной локализации [3,4].…”

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Experimental evaluation of the efficiency of chitosan matrixes under conditions of modeling of bone defect in vivo (preliminary message)

Vissarionov

Валентинович²,

Asadulaev

et al. 2020

Pediatr Traum Orthop Reconstr Surg

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Background. Despite the wide range of studies, the development of osteoplastic material, which has not only osteoconductive but also osteoinductive properties, remains an extremely topical issue in modern medical materials science. This work is devoted to experimental evaluation of the effectiveness of synthetic osteoplastic composite material based on chitosan and hydroxyapatite. Aim. This study aimed to determine the effects of spongy implants based on chitosan and its composite with hydroxyapatite nanoparticles in an amount of 50 wt. % on early osteogenesis in the area of the through defect of the ileum. Materials and methods. The studied materials were sponge implants based on chitosan and its composite with hydroxyapatite nanoparticles in an amount of 50 wt. %. Comparison groups include those without implant placement and those with replacement with commercial Reprobone osteoplastic material. Materials were implanted into the zone of the through defect of the ileum of rabbits for a period of 28 days. Results. A high rate of resorption of materials based on chitosan in bone tissue and active growth of reticulofibrotic bone tissue along the edges of the defect was established, and the formation of cartilaginous islands and bone marrow was recorded in the group of chitosan implants with hydroxyapatite. The aseptic effect was observed with the use of implants made of chitosan and hydroxyapatite. Conclusions. The data obtained allow us to argue about the osteoconductivity of the studied materials and the prospects for further development in this direction.

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