Recovery from unilateral 6-hydroxydopamine lesion of substantia nigra promoted by the neurotachykinin substance P1–11

Mattioli, Rosana; Schwarting, Rainer K.W.; Huston, Joseph P.

doi:10.1016/0306-4522(92)90404-p

Cited by 55 publications

(31 citation statements)

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“…Secondly, it has been demonstrated that several neuropeptides can promote processes related to functional recovery following CNS damage (Dekker et al 1987;Pitsikas et al 1991;Mattioli et al 1992;Lestage et al 1998a) and display neurotrophic actions in vitro (Iwasaki et al 1989;Whitty et al 1993). Thirdly, a number of neuropeptides are also found to be reduced in aged animals and humans (Buck et al 1981;Dupont et al 1981;Wang et al 1981).…”

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confidence: 99%

Further Evidence for a Dissociation Between Different Forms of Mnemonic Expressions in a Mouse Model of Age-related Cognitive Decline: Effects of Tacrine and S 17092, a Novel Prolyl Endopeptidase Inhibitor

Marighetto¹,

Touzani²,

Etchamendy³

et al. 2000

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It has been demonstrated previously on the radial maze that the emergence of an age-related mnemonic impairment is critically dependent on the form which the discrimination problems took. Hence, when the arms were presented one by one (i.e., successive go-no-go discrimination), both adult and aged mice learned to distinguish between positive (baited) and negative (unbaited) arms readily, as evidenced by their increased readiness to enter positive relative to negative arms (i.e., by a differential in arm-entry latencies). A selective impairment in the aged mice was seen when these arms were presented subsequently as pairs, such that the mice were confronted with an explicit choice (i.e., simultaneous 2-choice discrimination). When discriminative performance was measured by the differential run speed between positive and negative arms, aged mice were also impaired. This was particularly pronounced in the 2-choice discrimination condition. We examined the effects of tacrine (3mg/kg, subcutaneously) or S 17092 (10mg/kg, orally) in aged mice on the three behavioral indices of this 2-stage spatial discrimination paradigm. The results indicated that: (1) Tacrine, but not S 17092, enhanced the acquisition of go-no-go discrimination as reflected in arm-entry latencies; (2) both drugs improved choice accuracy in simultaneous discrimination, although the effect of tacrine was less striking and, in particular, far from statistical significance in the very first 2-choice responses; and (3) neither drugs significantly affected run-speed performance. We conclude further that the specific patterns of drug effects on the three indices of discriminative performance might suggest that each index is associated with a distinct form of mnemonic expression relying on separate neural systems.In humans, declarative/explicit memory appears to be more vulnerable to deterioration in senescence than procedural/ implicit memory (Poon 1985;Gabrieli 1996;Schugens et al. 1997). One cardinal characteristic of declarative memory is its flexibility as exemplified by its capacity to support inferential use of memories in novel situations (Cohen 1984). Using a two-stage paradigm of discrimination learning, Marighetto et al. (1999) have previously demonstrated that aged mice displayed impaired inferential abilities when they were required to make an explicit choice between two eventualities that were only encountered before separately, but never conjointly. In Stage 1, the mice learned to discriminate between the valence of three baited (positive) and three unbaited (negative) arms in a radial maze with each of the arms presented one at a time, i.e., successive go-no-go discrimination. Successful discrimination was indicated by the animals' increased readiness to enter positive arms relative to negative ones. In Stage 2, the animals were confronted with an explicit choice between one positive arm and one negative arm they had learned to discriminate previously. Aged mice, but not young ones, were unable to translate their preference for the positive ...

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confidence: 99%

Further Evidence for a Dissociation Between Different Forms of Mnemonic Expressions in a Mouse Model of Age-related Cognitive Decline: Effects of Tacrine and S 17092, a Novel Prolyl Endopeptidase Inhibitor

Marighetto¹,

Touzani²,

Etchamendy³

et al. 2000

Learn. Mem.

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“…2 (Flohr & Ltineburg, 1982;Igarashi et al, 1985;Mattioli et al, 1992;Antonawich et al, 1993;Bannon et al, 1995;Sprick et al, 1996). Such promotive effects might be due to their known neurotrophic effects (Jonsson & Hallman, 1982;Nyakas et al, 1985;van der Neut et al, 1988;Iwasaki et al, 1989;Kowall et al, 1991).…”

Section: Resultsmentioning

confidence: 99%

“…bilateral adjustments in the activity of vestibular nuclei (Flohr & Beinhold, 1981;Sans et al, 1997), modulation of the lesion side via commissural interconnections (Dieringer & Precht, 1979), cerebellar input to the vestibular neurons (Dieringer & Precht, 1979), and neurochemical modulation via cholinergic systems (Beinhold & Flohr, 1980 (Schaefer & Meyer, 1974) to promote functional recovery after brain lesions (Mattioli et al, 1992;Bannon et al, 1995) and to act in a neurotrophic and neuroprotective way (Jonsson & Hallman, 1982;Iwasaki et al, 1989;Kowall et al, 1991;Mattioli et al, 1992;Nikolaus et al, 1999). ACTH4-10 can also accelerate recovery after hemilabyrithectomy in frogs (Flohr & Liineburg, 1982) and monkeys (Igarashi et al;1985) and after lesions of the CNS (Antonawich et al, 1993; for review see van Rijzingen et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

ACTH4 ‐10, Substance P, and Dizolcipine (Mk‐801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish

2000

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SUMMARYIn this study, we evaluated the goldfish model of hemilabyrinthectomy for investigating potential recovery-promoting drugs. In this lesion model, the unilateral removal of the labyrinth induces a postural imbalance in response to light (Dorsal Light Reflex), from which the animals can recover over time. The behavioral effects of two neuropeptides were testednamely, of substance P and ACTH4-10, both of which are known to promote functional recovery in several other lesion models. Furthermore, the effect of MK-801, an antagonist of the glutamatergic NMDAreceptor subtype, was tested because this substance has also been shown to exert a neuroprotective effect. After lesion of the right labyrinth, the animals (n=12) were treated intraperitoneally daily either with vehicle (n=12), substance P (n=ll),

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“…Therefore, it has been hypothesized that manipulation of substance P-ergic system may have therapeutic effects in the treatment of Parkinson's disease. Indeed, in animal model of Parkinson's disease, it has been shown that pre- or post-treatment with substance P or its C-terminal can promote functional recovery in partial nigrostriatal dopamine lesions (Mattioli et al, 1992; Nikolaus et al, 1997, 1999). However, up to now, the reasons for substance P-induced neuroprotection for Parkinson's disease are unclear.…”

Section: Discussionmentioning

confidence: 99%

Neurokinin-1 receptor activation in globus pallidus

2009

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The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine the electrophysiological effects of neurokinin-1 receptor activation in globus pallidus, whole-cell patch-clamp recordings were performed in the present study. Under current-clamp recordings, neurokinin-1 receptor agonist, [Sar9, Met(O2)11] substance P (SM-SP) at 1 μM, depolarized globus pallidus neurons and increased their firing rate. Consistently, SM-SP induced an inward current under voltage-clamp recording. The depolarization evoked by SM-SP persisted in the presence of tetrodotoxin, glutamate and GABA receptor antagonists, indicating its direct postsynaptic effects. The neurokinin-1 receptor antagonist, SR140333B, could block SM-SP-induced depolarization. Further experiments showed that suppression of potassium conductance was the predominant ionic mechanism of SM-SP-induced depolarization. To determine if neurokinin-1 receptor activation exerts any effects on GABAergic and glutamatergic neurotransmission, the action of SM-SP on synaptic currents was studied. SM-SP significantly increased the frequency of spontaneous inhibitory postsynaptic currents, but only induced a transient increase in the frequency of miniature inhibitory postsynaptic currents. No change was observed in both spontaneous and miniature excitatory postsynaptic currents. Based on the direct excitatory effects of SM-SP on pallidal neurons, we hypothesize that neurokinin-1 receptor activation in globus pallidus may be involved in the beneficial effect of substance P in Parkinson's disease.

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Recovery from unilateral 6-hydroxydopamine lesion of substantia nigra promoted by the neurotachykinin substance P1–11

Cited by 55 publications

References 64 publications

Further Evidence for a Dissociation Between Different Forms of Mnemonic Expressions in a Mouse Model of Age-related Cognitive Decline: Effects of Tacrine and S 17092, a Novel Prolyl Endopeptidase Inhibitor

Further Evidence for a Dissociation Between Different Forms of Mnemonic Expressions in a Mouse Model of Age-related Cognitive Decline: Effects of Tacrine and S 17092, a Novel Prolyl Endopeptidase Inhibitor

ACTH4 ‐10, Substance P, and Dizolcipine (Mk‐801) Accelerate Functional Recovery After Hemilabyrinthectomy in Goldfish

Neurokinin-1 receptor activation in globus pallidus

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