Recovery of oxidative stress-induced damage in Cisd2-deficient cardiomyocytes by sustained release of ferulic acid from injectable hydrogel

Cheng, Yung Hsin; Lin, Feng Huei; Wang, Chien Ying; Hsiao, Chen Yuan; Chen, Hung Ching; Kuo, Hsin Yu; Tsai, Ting Fen; Chiou, Shih Hwa

doi:10.1016/j.biomaterials.2016.06.060

Cited by 38 publications

(26 citation statements)

References 48 publications

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“…In addition, MSCs from the umbilical cord require a longer period of time to differentiate into osteoblasts (15). Although the use of BMP-2 for bone tissue regeneration has been extensively investigated (16–18), the BMP-2-induced osteogenic differentiation of MSCs derived from the umbilical cord has not been fully examined, in particular as regards the underlying molecular events governing osteogenic differentiation.…”

Section: Introductionmentioning

confidence: 99%

Bone morphogenetic protein-2 enhances the osteogenic differentiation capacity of mesenchymal stromal cells derived from human bone marrow and umbilical cord

Marupanthorn

Tantrawatpan

Kheolamai

et al. 2017

International Journal of Molecular Medicine

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Mesenchymal stromal cells (MSCs) are multipotent cells that can give rise to different cell types of the mesodermal lineages. They are powerful sources for cell therapy in regenerative medicine as they can be isolated from various tissues, and can be expanded and induced to differentiate into multiple lineages. Recently, the umbilical cord has been suggested as an alternative source of MSCs. Although MSCs derived from the umbilical cord can be induced to differentiate into osteoblasts with a phenotypic similarity to that of bone marrow-derived MSCs, the differentiation ability is not consistent. In addition, MSCs from the umbilical cord require a longer period of time to differentiate into osteoblasts. Previous studies have demonstrated the benefits of bone morphogenetic protein-2 (BMP-2) in bone tissue regeneration. In addition, several studies have supported the use of BMP-2 in periodontal regeneration, sinus lift bone-grafting and non-unions in oral surgery. Although the use of BMP-2 for bone tissue regeneration has been extensively investigated, the BMP-2-induced osteogenic differentiation of MSCs derived from the umbilical cord has not yet been fully examined. Therefore, in this study, we aimed to examine the effects of BMP-2 on the osteogenic differentiation of MSCs derived from umbilical cord compared to that of MSCs derived from bone marrow. The degree of osteogenic differentiation following BMP-2 treatment was determined by assessing alkaline phosphatase (ALP) activity, and the expression profiles of osteogenic differentiation marker genes, osterix (Osx), Runt-related transcription factor 2 (Runx2) and osteocalcin (Ocn). The results revealed that BMP-2 enhanced the osteogenic differentiation capacity of MSCs derived from both bone marrow and umbilical cord as demonstrated by increased ALP activity and the upregulation of osteogenic differentiation marker genes. The enhancement of the osteogenic differentiation capacity of MSCs by BMP-2 suggests that these MSCs may be used as alternative sources for bone engineering or cell therapy in regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

Bone morphogenetic protein-2 enhances the osteogenic differentiation capacity of mesenchymal stromal cells derived from human bone marrow and umbilical cord

Marupanthorn

Tantrawatpan

Kheolamai

et al. 2017

International Journal of Molecular Medicine

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“…The cytotoxicity of G/C/GP hydrogel on iPSCs was examined using an extraction method 15 , 16 . A total of 0.1 g G/C/GP hydrogel was immersed in 1 ml mESCM in a 48-well culture plate at 37 °C.…”

Section: Methodsmentioning

confidence: 99%

“…A mixture of hydrogel and iPSCs repaired a corneal epithelial wound significantly faster than iPSCs alone 14 . This thermosensitive hydrogel, therefore, may be an ideal bio-scaffold to increase iPSCs engraftment and survival 16 . We have developed a novel injectable hydrogel to enhance stem cell delivery and engraftment in injured corneas using the same methods as in our prior study 14 .…”

Section: Introductionmentioning

confidence: 99%

Promoting Induced Pluripotent Stem Cell-driven Biomineralization and Periodontal Regeneration in Rats with Maxillary-Molar Defects using Injectable BMP-6 Hydrogel

Chien

Chang

Wang

et al. 2018

Sci Rep

Self Cite

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Periodontal disease may cause considerable destruction of alveolar bone, periodontal ligaments (PDLs) and cementum and even lead to progressive oral dysfunction. Periodontal tissue regeneration is the ultimate goal of periodontal disease treatment to reconstruct both structures and functions. However, the regenerative efficiency is low, possibly due to the lack of a proper periodontal microenvironment. In this study, we applied an injectable and thermosensitive chitosan/gelatin/glycerol phosphate hydrogel to provide a 3D environment for transplanted stem cells and to enhance stem cell delivery and engraftment. The iPSCs-BMP-6-hydrogel complex promoted osteogenesis and the differentiation of new connective tissue and PDL formation. In animal models of maxillary-molar defects, the iPSCs-BMP-6-hydrogel-treated group showed significant mineralization with increased bone volume, trabecular number and trabecular thickness. Synergistic effects of iPSCs and BMP-6 increased both bone and cementum formation. IPSCs-BMP-6-hydrogel-treated animals showed new bone synthesis (increased ALP- and TRAP-positive cells), new PDL regeneration (shown through Masson’s trichrome staining and a qualification assay), and reduced levels of inflammatory cytokines. These findings suggest that hydrogel-encapsulated iPSCs combined with BMP-6 provide a new strategy to enhance periodontal regeneration. This combination not only promoted stem cell-derived graft engraftment but also minimized the progress of inflammation, which resulted in highly possible periodontal regeneration.

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“…Drug delivery with hydrogel can change the harsh environment of diseased tissue (Hasan et al, 2015). Hydrogels have a highly porous structure in which irregular pores are connected to each other throughout the structure (Trombino et al, 2019), and the drug or a biologically active substance like a liposome-encapsulated alpha-tocopherol (Qu et al, 2019) or Ferulic acid (FA) (Cheng et al, 2016) is uniformly distributed in the porous structure. The inlaid structure of the hydrogel creates a sustained release system to sustained-release to resists oxidative stress inflammatory response and improved cardiomyocyte survival rate.…”

Section: Drugsmentioning

confidence: 99%

“…All in all, as for treating CVDs, revascularization and stem cell homing are the two major effective strategies through injectable hydrogel as a delivery system in the recent years. Besides, there existing other approach that would hold great therapeutic potential in the field of CVDs treatment, for instance, taking advantage of an injectable hyaluronic acid (HA) hydrogel to deliver miRNA in order to induce proliferation in cardiomyocytes through its inhibition of Hippo signaling via a direct binding site on the 3 UTR, such as miR-302 and miR-1825 (Pandey et al, 2017), developing a new hydrogel (Qi et al, 2018) from supramolecular assembling of a synthetic glycol peptide which endows the hydrogel with the capacity of endothelial cell adhesion and proliferation due to its high density of glucose moieties, as well as using Ferulic Acid (Kanki and Klionsky, 2009;Wu et al, 2012;Wiley et al, 2013) (a natural antioxidant that is most abundant in vegetables, especially in eggplants and maize bran) to form a new injectable hydrogel (Cheng et al, 2016) to effectively promote the recovery of Cisd2 deficiency induced damage.…”

Section: The Therapeutic Effect In Cvds Through Promoting Stem Cell Hmentioning

confidence: 99%

Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

Liao

Yang

Deng

et al. 2020

Front. Bioeng. Biotechnol.

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Cardiovascular diseases (CVDs), including a series of pathological disorders, severely affect millions of people all over the world. To address this issue, several potential therapies have been developed for treating CVDs, including injectable hydrogels as a minimally invasive method. However, the utilization of injectable hydrogel is a bit restricted recently owing to some limitations, such as transporting the therapeutic agent more accurately to the target site and prolonging their retention locally. This review focuses on the advances in injectable hydrogels for CVD, detailing the types of injectable hydrogels (natural or synthetic), especially that complexed with stem cells, cytokines, nano-chemical particles, exosomes, genetic material including DNA or RNA, etc. Moreover, we summarized the mainly prominent mechanism, based on which injectable hydrogel present excellent treating effect of cardiovascular repair. All in all, it is hopefully that injectable hydrogel-based nanocomposites would be a potential candidate through cardiac repair in CVDs treatment.

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Recovery of oxidative stress-induced damage in Cisd2-deficient cardiomyocytes by sustained release of ferulic acid from injectable hydrogel

Cited by 38 publications

References 48 publications

Bone morphogenetic protein-2 enhances the osteogenic differentiation capacity of mesenchymal stromal cells derived from human bone marrow and umbilical cord

Bone morphogenetic protein-2 enhances the osteogenic differentiation capacity of mesenchymal stromal cells derived from human bone marrow and umbilical cord

Promoting Induced Pluripotent Stem Cell-driven Biomineralization and Periodontal Regeneration in Rats with Maxillary-Molar Defects using Injectable BMP-6 Hydrogel

Injectable Hydrogel-Based Nanocomposites for Cardiovascular Diseases

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