Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile

Desaphy, Jean-François; Pierno, Sabata; Liantonio, Antonella; A, De Luca; Didonna, Maria Paola; Frigeri, Antonio; Nicchia, Grazia Paola; Svelto, María; Camerino, Claudia; Zallone, Alberta; Camerino, Diana Conte

doi:10.1016/j.nbd.2004.09.016

Cited by 68 publications

(71 citation statements)

References 47 publications

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“…Also muscle ion channels are critical determinants of the muscle phenotype, because they control excitability and excitation/ contraction coupling, and modulate contraction and gene expression. We previously found important modifications of ion channel function and expression during HU, which were mainly in accordance with the phenotype transition (Desaphy et al , 2005Frigeri et al 2001;Pierno et al 2002Pierno et al , 2007Fraysse et al 2003;Tricarico et al 2005). The expression of the ClC-1 chloride channel, which is responsible for the resting chloride conductance of sarcolemma, is greater in fast-twitch muscles compared to slowtwitch muscles (Steinmeyer et al 1991;Pierno et al 1999).…”

Section: Introductionmentioning

confidence: 63%

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Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat

et al. 2011

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Hindlimb unloading (HU) in rats induces severe atrophy and a slow-to-fast phenotype transition in postural slow-twitch muscles, as occurs in human disuse conditions, such as spaceflight or bed rest. In rats, a reduction of soleus muscle weight and a decrease of cross-sectional area (CSA) were observed as signs of atrophy. An increased expression of the fast-isoform of myosin heavy chain (MHC) showed the phenotype transition. In parallel the resting cytosolic calcium concentration (restCa) was decreased and the resting chloride conductance (gCl), which regulates muscle excitability, was increased toward the values of the fast-twitch muscles. Here, we investigated the possible role of taurine, which is known to modulate calcium homeostasis and gCl, in the restoration of muscle impairment due to 14-days-HU. We found elevated taurine content and higher expression of the taurine transporter TauT in the soleus muscle as compared to the fast-twitch extensor digitorum longus (EDL) muscle of control rats. Taurine level was reduced in the HU soleus muscle, although, TauT expression was not modified. Taurine oral supplementation (5 g/kg) fully prevented this loss, and preserved resting gCl and restCa together with the slow MHC phenotype. Taurine supplementation did not prevent the HU-induced drop of muscle weight or fiber CSA, but it restored the expression of MURF-1, an atrophy-related gene, suggesting a possible early protective effect of taurine. In conclusion, taurine prevented the HU-induced phenotypic transition of soleus muscle and might attenuate the atrophic process. These findings argue for the beneficial use of taurine in the treatment of disuse-induced muscle dysfunction.

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Section: Introductionmentioning

confidence: 63%

“…Immunohistochemistry and muscle fiber cross-sectional area Expression of MHC isoforms was determined by immunofluorescence staining as described previously (Frigeri et al 2001;Pierno et al 2002;Desaphy et al 2005). Briefly, soleus and EDL muscles were frozen in isopentane cooled in liquid nitrogen immediately after dissection.…”

Section: Treatment and Animal Carementioning

confidence: 99%

Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat

et al. 2011

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“…For example, complete recovery after a 2-week hindlimb suspension required 3-4 weeks (J. Desaphy et al, 2005). In view of this finding, preventing muscle atrophy is important, to avoid the need for such rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

Molecular Evidence: EA May Inhibit the Muscle Atrophy

Takaoka¹,

Ohta²,

Sugano³

2011

Acupuncture - Clinical Practice, Particular Techniques and Special Issues

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“…Reloading after hindlimb suspension in present study shows that collagen III mRNA level on the end of second week is higher than in control group. Two weeks of reloading have been shown to restore the Sol muscle metabolism [3]. Full recovery of ST muscle function via cross-sectional area and myonuclear domain size has been shown need more time for restoration of neural and mechanical properties of muscle [25].…”

Section: Discussionmentioning

confidence: 99%

The effect of unloading and reloading on the extracellular matrix in skeletal muscle: changes in muscle strength and motor activity

Riso¹,

Ahtikoski²,

Takala³

et al. 2010

Biol Sport

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Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile

Cited by 68 publications

References 47 publications

Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat

Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat

Molecular Evidence: EA May Inhibit the Muscle Atrophy

The effect of unloading and reloading on the extracellular matrix in skeletal muscle: changes in muscle strength and motor activity

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