Rectal application of argan oil improves healing of colorectal anastomosis in rats

Barlas, Aziz Mutlu; Kuru, Serdar; Kısmet, Kemal; Çavuşoğlu, Turgut; Bağ, Yusuf Murat; Şeneş, Mehmet; Cihan, Neslihan; Çelepli, Pınar; Ünal, Yasemin; Hücümenoğlu, Sema

doi:10.1590/s0102-865020180070000002

Cited by 8 publications

(6 citation statements)

References 19 publications

(27 reference statements)

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“…Many agents have been used to forestall adhesion formation by delimitating inflammatory reactions during peritoneal healing, thereby reducing the creation of a fibrinous network between serosal surfaces. [12][13][14]17,19,20] Although detecting the properties of KO that depress the formation of peritoneal adhesions may be an issue of another study, we think the administration of omega-3 sources (either KO or FO) decreases the inflammation on peritoneal surfaces in the critical stage of peritoneal wound healing.…”

Section: Discussionmentioning

confidence: 98%

“…Many investigators have researched on anastomotic wound healing process. [12,14,[17][18][19][20] And these studies also investigated the effectiveness of diverse systemic or local applied agents on the anastomotic healing process. [17,21,22] Inflammation during wound healing process stimulates the formation of fibrous bands between serosal surfaces ultimately.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the effects of two different marine-derived omega- 3 fatty acid sources, krill oil and fish oil, on the healing of primary colonic anastomoses after colectomy applied Wistar albino rat model

Ferhatoğlu

Kıvılcım

Vural

et al. 2019

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Oils from marine organisms have a different fatty acid composition. Fish oil (FO) has a high content of eicosapentaenoic and docosahexaenoic acids esterified to triacylglycerols; while in krill oil (KO), fatty acids are primarily esterified to phospholipids. This study aimed to compare the efficacy of two different, marine-derived omega-3 fatty acid sources in the wound healing of colon anastomoses rat model. METHODS: For the study, we used 42 male Wistar albino rats. The rats were divided into six groups with seven rats in each group-CO3: left colonic anastomosis (control group), sacrificed on the third day; KO3: left colonic anastomosis + oral KO, sacrificed on the third day; FO3: left colonic anastomosis + oral FO, sacrificed on the third day; CO7: left colonic anastomosis (control group), sacrificed on the seventh day; KO7: left colonic anastomosis + oral KO, sacrificed on the seventh day; FO7: left colonic anastomosis + oral FO, sacrificed on the seventh day. Peritoneal adhesions, anastomotic bursting pressures, hydroxyproline levels, and histological examination of the anastomotic tissue were evaluated. RESULTS: On day 7, bursting pressure and hydroxyproline measurements of the KO group was significantly higher than the FO group (p=0.012; p=0.002, respectively). Also, on day 7, a statistically significant difference was observed between the groups according to inflammatory cell infiltration, fibroblast activity, neoangiogenesis, and collagen deposition in favor of the KO group (p=0.023; p=0.028; p=0.016; p=0.012, respectively). CONCLUSION: Both KO and FO supplementation in patients before colorectal surgery may reduce some risk of anastomotic leakage; and KO might be a better alternative and excellent omega-3 source.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of two different marine-derived omega- 3 fatty acid sources, krill oil and fish oil, on the healing of primary colonic anastomoses after colectomy applied Wistar albino rat model

Ferhatoğlu

Kıvılcım

Vural

et al. 2019

Ulus Travma Acil Cerrahi Derg

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“…It is rich in oleic and linoleic fatty acids, and vitamin E, being mostly known for its antioxidant, anti-inflammatory, anti-hypercholesterolemia, anti-carcinogenic, anti-acne, anti-obesity, anti-aging and anti-glycemic properties. [24,25] Aiming to investigate its antioxidant power, Barlas et al [26] performed colon anastomosis in 30 female rats, applying argan oil in the suture line of the experimental group and NaCl 0,9% the control group. After that, during the post-op, both substances were rectally applied in its respective groups for 8 days, until the animals were euthanized.…”

Section: Argan Oilmentioning

confidence: 99%

Use of Antioxidant Substances in Intestinal Anastomosis in Rats

Carneiro

Yasojima²,

Costa³

et al. 2019

int arch med

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Introduction: Intestinal anastomosis consist of surgical procedures which there is an anastomotic line between two intestinal segments in order to reconstruct or divert the digestive transit. However, several complications may result from this surgical procedure. Objective: Present, describe and discuss the findings of the literature regarding substances capable of reducing injury and possible complications of intestinal anastomoses. Method: The data were collected by literature review using the descriptors: "intestinal anastomoses", "antioxidants"; and as basis articles published in the published Scientific Electronic Library (Scielo), Lilacs, MedLine and Pubmed databases. Inclusion criteria were original and review articles published in full in the online form in the Portuguese, Spanish and English languages, using the descriptors mentioned above in the respective languages. Results: Scientific articles were collected, in which 38 papers were included in the inclusion criteria. Conclusions: The major parts of substances described in the present study demonstrated be statistically relevant results and the capacity to optimize the anastomotic healing.

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“…Colorectal anastomotic leakage can cause devastating acute and long-term consequences, such as the need for additional intervention, prolonged hospital stay, and higher morbidity and mortality rates [1]. For many years, studies have been conducted not only for the development of new surgical techniques but also for the evaluation of locally or systemically applied products to prevent anastomotic leakage, but no method that is still widely used has been found as yet [2].…”

Section: Introductionmentioning

confidence: 99%

Does Rectal Application of Red-Ginseng have an Effect on Colorectal Anastomosis Healing? An Experimental Study

Şenlikçi¹,

Koşmaz

Durhan

et al. 2021

Archives of Clinical and Experimental Medicine

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Aim: To evaluate the possible effects of red-ginseng on colon anastomosis healing in an experimental rat model. Methods: In Group 1 (sham), laparotomy and colonic mobilization were performed. Colonic transection and anastomosis were performed to Groups 2 and 3. In Group 2 (control), 2 ml of saline was administered rectally to all rats for 10 days. Group 3 (drug group) rats were given 2.5 gr/kg ml red ginseng extract rectally for 10 days. Results: The rats in the sham group had the highest bursting pressure and the rats in the red ginseng group had higher bursting pressure than in the control group (p<0.05). A significant difference was observed only for the total SH level between the control group and the red ginseng group (p= 0.008). The red ginseng group had the highest scores for all parameters in the histopathological evaluation and the differences were significant compared to both the sham group and the control group. Conclusion: Rectally administered red-ginseng significantly increased wound healing parameters and increased anastomotic burst pressure. This is the first study in the literature on the beneficial effects of red-ginseng on colorectal anastomoses.

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Rectal application of argan oil improves healing of colorectal anastomosis in rats

Abstract: The rectally administered argan oil was observed to have significantly ameliorated wound healing parameters and exerted a significant antioxidant effect. This is the first study in the literature about the beneficial effects of argan oil on colorectal anastomoses.

Cited by 8 publications

References 19 publications

Comparison of the effects of two different marine-derived omega- 3 fatty acid sources, krill oil and fish oil, on the healing of primary colonic anastomoses after colectomy applied Wistar albino rat model

Comparison of the effects of two different marine-derived omega- 3 fatty acid sources, krill oil and fish oil, on the healing of primary colonic anastomoses after colectomy applied Wistar albino rat model

Use of Antioxidant Substances in Intestinal Anastomosis in Rats

Does Rectal Application of Red-Ginseng have an Effect on Colorectal Anastomosis Healing? An Experimental Study

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