Rectal bleeding and its management after irradiation for uterine cervical cancer

Late Effects After Radiotherapy for Locally Advanced Cervical Cancer: Comparison of Two Brachytherapy Schedules and Effect of Dose Delivered Weekly

“…Many studies have, however, found a relationship between the total dose to the ICRU rectum point and rectal complications (4,7,17,(22)(23)(24)(25), although others have supported our findings and failed to find such a correlation (6,20,26) The examples given have demonstrated that even if several investigators have found a correlation between the dose to the ICRU rectum point and late complications, the results of the analyses have been rather inconsistent and the suggested thresholds have differed. This is probably because a point dose is inadequate to establish general constraints for the organs at risk that receive a highly inhomogeneous dose distribution.…”

Fractionation and late rectal toxicity

“…Late rectal bleeding is well established as a key doselimiting end point in prostate radiotherapy (1)(2)(3)(4)(5)(6) and is an important consideration in cervical cancer radiotherapy (7)(8)(9). Consequently, much effort has been devoted to establishing dose-response relations for rectal bleeding (1)(2)(3)(4)(5)(6)(7)(8).…”

Sucralfate Protects Blood Clots from Peptic Digestion by Gastric Juice in vitro

“…But no clinical studies indicate that sucralfate delays haemostasis. On the contrary, sucralfate has been used extensively in a variety of potential bleeding conditions such as stress ulcer, NSAID gastropathy, rectal ulcer, gastric carcinoma, rectal carcinoma, and even bleeding from malignant skin ulcers [34,35,36,37]. Our study differs principally from that of Patchett and O’Donoghue [12].…”