Rectal MALT lymphoma associated with ulcerative colitis

Mangla, Vivek; Pal, Sujoy; Dash, Nihar Ranjan

doi:10.7869/tg.2012.55

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…Some patients were asymptomatic at diagnosis, and they underwent further testing because of positive stool occult blood results. For the case report of rectal MALT lymphoma in ulcerative colitis 21 , the patient was a 19-year old woman with steroid dependent ulcerative colitis for 3 years. She underwent a three-stage proctocolectomy and ileal pouch-anal anastomosis.…”

Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis Diagnosed in a Patient after Primary Rectal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Treated

Chan

Leow

2015

Proceedings of Singapore Healthcare

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A 39-year-old woman presented with loose stool and rectal bleeding for 1 year. A colonoscopy was performed and revealed proctitis. Rectal biopsy revealed a diagnosis of rectal marginal B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). She was treated with a course of chemotherapy rituximab. However, her symptoms persisted and a repeat colonoscopy showed features consistent with ulcerative colitis. She received topical mesalazine and her symptoms resolved. Another repeat colonoscopy showed evidence of inactive chronic colitis only. This is a rare report of ulcerative colitis being diagnosed after rectal MALT was treated. It is possible that she might have long-standing ulcerative colitis that was undiagnosed, with the rectal MALT lymphoma masking the features of ulcerative colitis. A few treatment modalities are available, and the prognosis in general is good.

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Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis Diagnosed in a Patient after Primary Rectal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Treated

Chan

Leow

2015

Proceedings of Singapore Healthcare

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“…In general, MALT lymphoma is an ambiguous entity and it shows inflammatory characteristics. Before the acceptance of the paper of Isaacson and Wright,[ 24 ] the gastric MALT lymphoma were called “reactive lymphoid hyperplasia” or “pseudolymphoma.” Such designations of inflammatory nature did not cause any problems. The discovery of H. pyroli highlighted the MALT, which are cured by eradication of H. pylori .…”

Section: Discussionmentioning

confidence: 99%

Extranodal marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue (MALT lymphoma) in ulcerative colitis

Terada¹

2014

Saudi J Gastroenterol

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Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) occurring in inflammatory bowel diseases, including ulcerative colitis (UC) and Crohn's disease, has been reported, although it is extremely rare. An 18-year-old man with a two-years history of UC underwent colon endoscopy, and was found to have active total UC ranging from anus to cecum. Six biopsies were obtained. The microscopic examinations showed severe infiltrations of atypical small lymphocytes. They showed hyperchromatic nuclei and increased nucleocytoplasmic ratio and scattered immunoblastic cells. Centrocyte-like atypical lymphocytes, monocytoid cells, and plasma cells were seen in some places. Vague germinal centers were present, and apparent lymphoepithelial lesions were seen. No crypt abscesses were seen, and there were few neutrophils. No apparent other findings of UC were seen. Immunohistochemically, the atypical lymphocytes were positive for vimentin, CD45, CD20, CD79α, CD138, κ-chain, λ-chain, and p53 and Ki-67 antigen (labeling index = 63%). They were also positive for CD45RO, CD3, and CD15, but these positive cells were very scant compared with CD20 and CD79α. They were negative for CD10, CD30, CD56, cytokeratin (CK) AE1/3, CK CAM5.2, CK34BE12, CK5, CK6, CK7, CK8, CK14, CK18, CK19, CK20, EMA, chromogranin, synaptophysin, NSE, S100 protein, CEA, CA19-9, p63, and HMB45. Without clinical information, the appearances are those of MALT lymphoma. However, with clinical information, making the diagnosis of MALT lymphoma was hesitated. It is only mentioned herein that atypical lymphocytic infiltrations indistinguishable from MALT lymphoma occurred in an 18-year-old male patient with a two-year history of UC.

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Mucosa-associated lymphoid tissue (MALT) variant of primary rectal lymphoma: a review of the English literature

Kelley

2016

Int J Colorectal Dis

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Rectal MALT lymphoma associated with ulcerative colitis

Cited by 5 publications

References 17 publications

Ulcerative Colitis Diagnosed in a Patient after Primary Rectal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Treated

Ulcerative Colitis Diagnosed in a Patient after Primary Rectal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Treated

Extranodal marginal zone B-cell lymphoma of Mucosa-Associated Lymphoid Tissue (MALT lymphoma) in ulcerative colitis

Mucosa-associated lymphoid tissue (MALT) variant of primary rectal lymphoma: a review of the English literature

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