Rectal metastases from lobular carcinoma of the breast: Report of a case and literature review

Bamias, Aristotelis; Baltayiannis, Gerasimos; Kamina, Sevasti; Fatouros, Michael; Lymperopoulos, E.; Agnanti, Niki; Tsianos, E.V.; Pavlidis, Nicholas

doi:10.1023/a:1011192827710

Cited by 59 publications

(54 citation statements)

References 14 publications

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“…These patients are characterized by a poor prognostic profile, and few survive longer than 2 years following their diagnosis with gastrointestinal metastasis [2]. Surgical treatment of the gastrointestinal metastasis of breast cancer does not seem to increase the survival rates, except in a subgroup of patients who exclusively suffer from this form of metastasis [9].…”

Section: Discussionmentioning

confidence: 99%

“…The most common sites of metastases for such carcinomas are the lungs, bones, brain and liver, whereas lesions in the gastrointestinal tract are rarely encountered [1]. Evidence in the literature concerning gastrointestinal metastases is limited, and mainly based on descriptive studies of autopsy series, clinical case reports and small series of patients [2]. Within the gastrointestinal tract, the stomach and the small intestine are the most common metastatic sites of lobular carcinoma, whereas large intestine metastases are very rare.…”

Section: Introductionmentioning

confidence: 99%

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Lobular Breast Cancer Metastasis to the Colon, the Appendix and the Gallbladder

et al. 2014

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Background: Metastases of lobular breast cancer are commonly encountered at the level of lungs, bones, brain and liver, whereas lesions in the gastrointestinal tract are rarely seen. Case Report: A case of a patient with metastases in the right colon and gallbladder originating from an invasive lobular carcinoma is described. Conclusion: Adequate diagnostic procedures should be performed in patients with a history of breast cancer and who show gastrointestinal symptoms to rule out the potential presence of gastrointestinal metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lobular Breast Cancer Metastasis to the Colon, the Appendix and the Gallbladder

et al. 2014

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“…Breast cancer is the most common cancer and one of the leading causes of death in women [1]. It most commonly metastasizes to lymph nodes, bones, lungs and brain but It is rare for breast cancer to cause extra-hepatic GI metastases [2].…”

Section: Discussionmentioning

confidence: 99%

Can Metastatic Breast Cancer Spread to the Colon?

Tahir¹,

Sohail²,

Singh³

2017

J Gastrointest Cancer Stromal Tumor

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“…Even though it is infrequent, it is important for physicians, especially primary care providers who follow oncology patients after treatment is rendered, to keep in mind that gastrointestinal complaints can occur years later and be the first signs of metastatic spread in patients with a history of breast cancer [18][19][20][21]. This is especially true for patients with lobular carcinoma due to its increased frequency of gastrointestinal metastases compared to ductal-type [3,22].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Metastases from Breast Cancer, a Diagnostic Dilemma

Wiisanen¹

2015

MOJCR

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IntroductionEvery year, approximately 225,000 women are diagnosed with breast cancer and another 40,000 die from the disease in the US. About 75% of all metastases will occur within the first 5 years after diagnosis of early-stage disease. This has been found to be especially true for hormone receptor-negative disease. Unfortunately, metastases can occur beyond that time, sometimes up to 30 years later, which is more common in hormone-positive disease [1,2]. Breast cancer will typically metastasize to lymph nodes, bone, lungs, liver, and brain. Most commonly, metastatic spread of any cancer type to the gastrointestinal tract is considered an uncommon phenomenon. One study of approximately 2500 cases, found only 21 patients (<1%) with metastasis to the gastrointestinal tract [3]. Of secondary tumors to the gastrointestinal tract, breast is second only to melanoma [4]. In one study that looked specifically at the colon and rectum, the leading source of metastases was breast, with melanoma second [5]. In an autopsy study performed on 707 cases of metastatic breast cancer, the stomach was involved in 10% of cases, small intestine in 9%, and large intestine in 8%, with the peritoneum involved in 25% of cases. Overall, the gastrointestinal tract was involved in 16% of cases [6] A non-autopsy study done in 2005 at The Mayo Clinic showed that of 12,000 diagnosed with metastatic disease secondary to breast cancer, 73 (0.6%) were found in either the GI tract or peritoneum: esophagus (8%), stomach (28%), small intestine (19%), and colon and rectum (45%) [7].Histological studies have found that lobular carcinoma metastasized to the same metastatic sites as ductal carcinoma; however lobular carcinoma frequently metastasized to unusual sites like the gastrointestinal tract, peritoneum, and adnexa [8][9][10][11][12]. In one of the earliest papers on the subject, all of the metastases to the stomach were infiltrating lobular cancer, and other papers had between 75-97% lobular histotype [13][14][15][16] AbstractBackground: Those diagnosed with breast cancer are surviving longer due to advances in treatment. Metastatic spread to any site may not occur for years after primary surgical and systemic treatments and will most likely be diagnosed by General Practitioners. Breast cancer rarely metastasizes to the gastrointestinal tract. Due to this, scarce literature is available; mostly case-reports or small caseseries. Our aim is to review two recent cases and to highlight our institution's data. General Practitioners need to remember the potential gastrointestinal metastatic spread of breast cancer.

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Rectal metastases from lobular carcinoma of the breast: Report of a case and literature review

Cited by 59 publications

References 14 publications

Lobular Breast Cancer Metastasis to the Colon, the Appendix and the Gallbladder

Lobular Breast Cancer Metastasis to the Colon, the Appendix and the Gallbladder

Can Metastatic Breast Cancer Spread to the Colon?

Gastrointestinal Metastases from Breast Cancer, a Diagnostic Dilemma

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