Rectal Plasmablastic Lymphoma in HIV/AIDS: Two Cases

López-Íñiguez, Álvaro; Llamas-Covarrubias, Mara Anaís; Navarro-Blackaller, Guillermo; Vélez-Gómez, Ezequiel; Gonzalez-Hernández, Luz Alicia; Campos-Loza, Ariel Eduardo; Amador-Lara, Fernando; Andrade-Villanueva, Jaime Federico

doi:10.4021/wjon627w

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…Isolated cases of plasmablastic lymphoma have been reported in the rectum with a presentation similar to that of the case presented, such as a rectal mass with signs of local inflammation. The mass tends to be painful on palpation, friable to the touch and protrudes through the anal canal with local invasion of surrounding tissues, which can be accompanied by rectal bleeding and pain on defecation [5][6][7][8]. Only scarce cases of plasmablastic lymphoma of the rectum have been reported in HIVnegative patients.…”

Section: Discussionmentioning

confidence: 99%

“…This was first described in 1997 in the oral cavity of patients with human immunodeficiency virus (HIV) infection. This began being considered an acquired immunodeficiency syndrome (AIDS)-defining neoplasm [1][2][3][4][5]. This represents approximately 2% of HIV-related lymphomas and less than 3% of all non-Hodgkin lymphomas [1,4].…”

Section: Introductionmentioning

confidence: 99%

“…This has been reported in several locations other than the one initially described in the oral cavity. The gastrointestinal tract, lymph nodes, and skin stand out, with the gastrointestinal tract being a rather challenging location in terms of its diagnosis [1][2][3][4][5]. Due to its difficult diagnosis because of its clinical presentation and variable location, it can initially be confused with other neoplasms of the gastrointestinal tract [1].…”

Section: Introductionmentioning

confidence: 99%

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Plasmablastic lymphoma in an HIV-negative patient with complete remission after chemotherapy with DA-EPOCH

Alburqueque-Melgarejo

Roque

Moscoso

et al. 2023

Hematology in Clinical Practice

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Plasmablastic lymphoma (PBL) is a rare subtype of diffuse large B-cell lymphoma originally described in human immunodeficiency virus (HIV)-positive patients. However, recent reports have described this neoplasia in HIV-negative patients. This neoplasia usually arises in extranodal tissues, such as the gastrointestinal tract, abdominal cavity and retroperitoneum. Here a case is presented of an HIV-negative patient with a history of stage II rectal cancer for which he received chemotherapy and radiotherapy with a complete response. However, in the following years, the patient presented clinical deterioration and the presence of an exophytic mass with fistulous tracts. For this reason, the patient underwent a new biopsy of the rectum which showed a plasmablastic lymphoma of the rectum, with an extensive local compromise that presented complete remission after 6 cycles of chemotherapy with a DA-EPOCH regimen.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasmablastic lymphoma in an HIV-negative patient with complete remission after chemotherapy with DA-EPOCH

Alburqueque-Melgarejo

Roque

Moscoso

et al. 2023

Hematology in Clinical Practice

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“…Taking into account the recommendations issued by The International Lymphoma Radiation Oncology Group (ILROG) for the treatment of hematological neoplasms during the COVID-19 pandemic, we are in the palliative field of a patient with an aggressive, symptomatic non-Hodgkin's lymphoma, so a hypofractionated scheme of 25 Gy in 5 Fractions was chosen, with an EQD2 for an α/β of 3 Gy = 40 Gy and an α/β of 10 Gy = 31 Gy, with the expectation of an equivalent biological effect that it would maintain the same level of tumor control, with a low risk of early and late toxicity in healthy tissues, given current radiotherapy techniques and the prescribed dose. [1][2][3][4][5][6][7][8][9][10][11][12][13]…”

Section: Discussionmentioning

confidence: 99%

Plasmablastic lymphoma with rectal activity in a patient with HIV: palliative treatment from the perspective of radiotherapy before the SARS-COV-2 contingency

Salvador¹,

Ramiro²,

Marco³

et al. 2022

IJRRT

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We present the case of an OLP with rectal activity in a patient with HIV, treated with radiotherapy during the SARS-CoV-2 contingency. Presentation of the caseA 38-year-old male, homosexual, with a condition of more than 12 months of evolution, characterized by persistent proctalgia and rectal bleeding associated with a palpable lesion in the anal region, profuse night sweats, and weight loss of 8 kg in 2 months. He was approached by a proctologist who diagnosed a perianal abscess, drained the abscess, and resected the perianal lesion; however, after the surgical procedure, she continued with symptoms and the appearance of new tumor growth in the gluteal and perianal region. He went again to a proctologist who performed a rectosigmoidoscopy in which an intrarectal tumor was identified, a biopsy was taken with a histopathological report of Plasmablastic Lymphoma,

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“…However, upon review, in fact, we found it to be the most common site for EoPL, with a total of 12 cases being identified from the available literature [6,16,17,20,21,22,23]. The other common sites include the stomach, skin, cervical lymph node and orbit, with a similar incidence [10,11,15,17,24,25,26,27,28,29,30,31,32,33,34].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Extraoral Plasmablastic Lymphoma Detected Using Ascitic Fluid Cytology and Flow Cytometry: A Case Report with a Review of the Literature

Dorwal

Sachdev²,

Mishra³

et al. 2014

Acta Cytologica

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Background: Plasmablastic lymphoma (PL) is a relatively new category of lymphoma, which has been considered to be found predominantly in the oral cavity and has a strong association with HIV. Case: We report a case of extraoral/mesenteric PL detected using cytological examination of ascitic fluid assisted by flow cytometric (FC) analysis. The cells were positive for CD38, CD138, CD10, CD45 and CD56 and negative for CD3, CD19, CD20 and CD79a, with cytoplasmic lambda light-chain restriction. We also reviewed 67 cases of extraoral PL from the available literature and found them to be less often associated with HIV (than oral PL), occurring mostly in males aged 30-60 years, with the most common extraoral site being the anorectal region. Conclusion: A high index of suspicion at the level of the cytopathologist is imperative for identifying lymphoma cells in a body fluid. A rare entity like PL can also be diagnosed on cytology assisted by ancillary techniques (like FC), without the need for a biopsy. We also suggest that the minimum panel to diagnose PLs should include CD138, MUM-1, Ki-67, ALK-1, CD3, immunoglobulin light-chains, CD20 and PAX5.

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Rectal Plasmablastic Lymphoma in HIV/AIDS: Two Cases

Cited by 4 publications

References 12 publications

Plasmablastic lymphoma in an HIV-negative patient with complete remission after chemotherapy with DA-EPOCH

Plasmablastic lymphoma in an HIV-negative patient with complete remission after chemotherapy with DA-EPOCH

Plasmablastic lymphoma with rectal activity in a patient with HIV: palliative treatment from the perspective of radiotherapy before the SARS-COV-2 contingency

Extraoral Plasmablastic Lymphoma Detected Using Ascitic Fluid Cytology and Flow Cytometry: A Case Report with a Review of the Literature

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