Recurrence of endometriosis; risk factors, mechanisms and biomarkers; review of the literature

Abstract

Endometriosis has a wide clinical spectrum and induces a chronic inflammatory process. The incidence of endometriosis in women with dysmenorrhoea is up to 40-60%, whereas in women with subfertility is up to 20-30%. Recurrence of endometriosis varies greatly among different studies. The overall recurrence rates range between 6 to 67% according to the criteria that are taken into consideration. Which of the various reasons is more predictive for recurrence is still unclear and controversial. The main aim of post-operative medical treatment is suppressing ovarian activity leading to atrophy of endometriotic lesions. The success of treatment depends on the resorption of all residual visible lesions and the eradication of microscopic implants. The recurrent lesions might originate from residual lesions or from de novo cells. Determining risk factors for recurrence may allow the identification of subgroups at risk for disease control. Potential biomarkers for recurrence could also maintain targeted therapy.

E2‐mediated EMT by activation of β‐catenin/Snail signalling during the development of ovarian endometriosis

“…Endometriosis, characterized by existence of endometrial‐like tissue outside of the uterine cavity, mainly causes chronic pelvic pain and infertility in women of reproductive years . Identification of mechanisms related to exact aetiology and pathogenesis of endometriosis are still elusive, and improvement of therapies is challenging …”

Umbilical Nodule with Cyclical Bleeding: A Case Report and Literature Review of Atypical Endometriosis

“…The main goal of postoperative medical treatment is suppressing ovarian activity resulting in atrophy of endometriotic lesions. The success of this therapy is related to the total excision of the endometriotic lesions so that the recurrence of the disease could be minimised and the absence of pain maintained [ 44 ]. Recurrence is rare after complete excision of the lesion [ 2 , 12 , 20 ].…”

“…The recurrent lesions can result from incomplete excision of previous lesions or from de novo cells. Identifying risk factors for recurrence may permit the recognition of subgroups at risk for disease control [ 44 ]. Several risk factors have been proposed, but there is controversy about which one is more predictive for recurrence.…”

Exploration of the pathological mechanism of endometriosis in rats using high-throughput sequencing

“…1 Health Management Center, RuiKang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China. 2 College of Acupuncture and Massage, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China.…”

“…Endometriosis (EMs) is a disease caused by the presence of endometrial tissue with growth ability and function in other parts of the body besides the mucous membrane of uterine cavity. The name of EMs was first described by Von Rokitansky in 1860, but its etiology and pathogenesis have not yet been fully elucidated [1,2]. EMs is characterized by secondary and progressive exacerbation of dysmenorrhea.…”