Recurrence of Relapsing Polychondritis on Tumor Necrosis Factor Antagonist Cessation and Starting an Interleukin-17 A Inhibitor

Abstract

Relapsing polychondritis (RP) is a rare autoimmune disorder that has been associated with various other autoimmune conditions. There have been no reported cases about any patient with psoriasis who has experienced RP recurrence associated with a change in biologic therapy. This is only the second case of a patient developing RP or RP recurrence associated with an Interleukin-17 A inhibitor or Tumor Necrosis Factor alpha inhibitor cessation. We present this case to increase physician awareness of a relationship between IL-17 A inhibitor use and the induction of relapsing polychondritis. In addition, we explore current literature related to IL-17 A inhibitor use in psoriasis.