Recurrence of Thoracic Esophageal Cancer after Lymph Node Dissection in Three Areas. With Special Reference to the Relationship between Recurrence and the Number of Metastatic Lymph Nodes.

Natsugoe, Shoji; Shimazu, Hisaaki; Baba, Masamichi; Yoshinaka, Heiji; Shimada, Mario; Haraguchi, Yusei; Shirao, Kazusada; Tanabe, Gen; Fukumoto, Toshitaka; Aikou, Takashi

doi:10.5833/jjgs.24.2888

Jpn J Gastroenterol Surg, Nihon Shokaki Geka Gakkai zasshi

1991

DOI: 10.5833/jjgs.24.2888

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Recurrence of Thoracic Esophageal Cancer after Lymph Node Dissection in Three Areas. With Special Reference to the Relationship between Recurrence and the Number of Metastatic Lymph Nodes.

Shoji Natsugoe¹,

Hisaaki Shimazu²,

Masamichi Baba³

et al.

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1994

1998

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Cited by 3 publications

(2 citation statements)

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“…Recurrence of esophageal carcinoma in patients following surgery is often seen, even in patients who were diagnosed as being free of lymph node metastases. 5 This phenomenon is proof that the spread of tumor cells is far greater than is detected by routine histopathologic studies.…”

mentioning

confidence: 82%

Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma

Natsugoe

Mueller

Stein

et al. 1998

Cancer

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mentioning

confidence: 82%

Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma

Natsugoe

Mueller

Stein

et al. 1998

Cancer

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“…However, the impact on overall patient survival is still not satisfactory. Recurrence of esophageal carcinoma in patients following surgery is often seen, even in patients who were diagnosed as being free of lymph node metastases 5. This phenomenon is proof that the spread of tumor cells is far greater than is detected by routine histopathologic studies.…”

mentioning

confidence: 88%

Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma

Natsugoe

Mueller

Stein

et al. 1998

Cancer

Self Cite

159

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BACKGROUND The purpose of this study was to investigate micrometastasis (MM) and tumor cell microinvolvement (TCM) in the regional lymph nodes of patients with esophageal squamous cell carcinoma (SCC). METHODS MM was defined as individual tumor cells or tumor cell clusters <0.5 mm in greatest dimension with a surrounding stromal reaction. TCM was defined as individual tumor cells or tumor cell clusters without a surrounding stromal reaction. One thousand nine hundred and fifty‐four lymph nodes were dissected from 69 complete (R0) resection specimens of TNM classified pT1‐3, pN0 or pN1, and M0 esophageal SCC. These lymph nodes were examined immunohistochemically using the monoclonal antibody cocktail AE1/AE3 for cytokeratins. The primary tumors were immunostained with an anti‐E‐cadherin monoclonal antibody. RESULTS MM ± TCM was found in 13 cases (31.7%) and TCM alone in 2 cases (4.9%) of the 41 pN0 cases. The pN0 patients with MM (but not TCM) had the same shorter survival as the original pN1 cases (P < 0.05). Of the 69 primary tumors, 49 (71.0%) had reduced or negative E‐cadherin expression that showed a correlation with the occurrence of lymph node metastases (original pN1), MM, and TCM, but not prognosis. CONCLUSIONS The results of the current study show that, in SCC of the esophagus, MM, but not TCM, in the regional lymph nodes is prognostically equivalent to metastasis and should be examined by immunohistochemistry to classify these cases correctly as pN1. Cancer 1998;83:858‐866. © 1998 American Cancer Society.

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The extent and number of metastatic lymph nodes limit the efficacy of lymphadenectomy in patients with oesophageal carcinoma

Yano¹,

Okamura²,

Yoshida³

et al. 1994

Surgical Oncology

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Recurrence of Thoracic Esophageal Cancer after Lymph Node Dissection in Three Areas. With Special Reference to the Relationship between Recurrence and the Number of Metastatic Lymph Nodes.

Cited by 3 publications

References 0 publications

Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma

Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma

Micrometastasis and tumor cell microinvolvement of lymph nodes from esophageal squamous cell carcinoma

The extent and number of metastatic lymph nodes limit the efficacy of lymphadenectomy in patients with oesophageal carcinoma

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