Recurrent airway obstruction (RAO) in horses is characterized by IFN-γ and IL-8 production in bronchoalveolar lavage cells

Ainsworth, Dorothy M.; Grünig, Gabriele; Matychak, Mary Beth; Young, Jean C; Wagner, Bettina; Erb, Hollis N.; Antczak, Douglas F.

doi:10.1016/s0165-2427(03)00142-9

Cited by 129 publications

(116 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The initial concentration of IL‐4 in the horses varied greatly. This is in accordance with the results of others studies 35, 36, 37, 38, 39 and shows the heterogeneous immunological phenotypes of the disease.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

A comparison of nanoparticulate CpG immunotherapy with and without allergens in spontaneously equine asthma‐affected horses, an animal model

Klier

Geis

Steuer

et al. 2017

Immunity Inflam & Disease

View full text Add to dashboard Cite

IntroductionNew therapeutic strategies to modulate the immune response of human and equine allergic asthma are still under extensive investigation. Immunomodulating agents stimulating T‐regulatory cells offer new treatment options beyond conventional symptomatic treatment or specific immunotherapy for human and equine allergic airway diseases, with the goal of a homoeostatic T‐helper cell balance. The aim of this study was to evaluate the effects of a nebulized gelatin nanoparticle‐CpG formulation (CpG‐GNP) with and without specific allergens for the treatment of spontaneous allergic equine asthma as a model for human asthma.MethodsTwenty equine asthma‐affected horses were treated either with CpG‐GNP alone or CpG‐GNP with allergens. Two specific allergens were selected for each horse based on history and an in‐vitro test. Each horse received seven administrations of the respective nebulized composition and was examined before treatment, immediately after and 6 weeks after the treatment course.ResultsClinical parameters such as breathing rate, indirect interpleural measurement, arterial blood gases, amount of tracheal mucus and percentage of neutrophils and cytokines in tracheal washes and serum samples were evaluated. Treatment with CpG‐GNP alone as well as in combinations with relevant allergens resulted in clinical improvement of nasal discharge, breathing rate, amount of secretion and viscosity, neutrophil percentage and partial oxygen pressure directly after and 6 weeks after treatment. There were no significant differences between the two treatments in clinical parameters or local cytokine profiles in the tracheal wash fluid (IL‐10, IFN‐g, and IL‐17). IL‐4 concentrations decreased significantly in both groups.ConclusionNonspecific CpG‐GNP‐based immunotherapy shows potential as a treatment for equine and possibly also human allergic asthma.

show abstract

Section: Discussionsupporting

confidence: 93%

“…Furthermore, the initial tracheal concentrations of IL‐17 varied greatly among horses. This fits to the reported local variations of cytokines in asthma‐afflicted horses probably due to genetic factors, the disease stage, and varying environmental allergen exposures 35, 36, 37, 38, 39, 62.…”

Section: Discussionsupporting

confidence: 90%

A comparison of nanoparticulate CpG immunotherapy with and without allergens in spontaneously equine asthma‐affected horses, an animal model

Klier

Geis

Steuer

et al. 2017

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

“…Whereas, in lung tissue obtained from unaffected horses, LPS exposure increases TLR4 mRNA expression (45), a recent report suggests that hay dust exposure does not change the TLR4 mRNA expression in the bronchial epithelial cells of RAO-affected horses (3). Furthermore, IL-8 mRNA expression and protein concentration measured in bronchoalveolar lavage fluid (BAL) are elevated in RAO-affected horses compared with control animals during stabling and in RAO-affected horses in remission (2,3,14).…”

mentioning

confidence: 99%

Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction

Berndt¹,

Derksen²,

Venta³

et al. 2007

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

show abstract

“…Recurrent airway obstruction is characterised by a hypersensitivity reaction to inhaled allergens that can affect genetically predisposed horses confined for long periods in stalls without proper ventilation and fed hay or other products with excessive chaff (Woods et al 1993, Ainsworth et al 2003, Radostits et al 2007, Gerber et al 2009. The exposure of susceptible horses to hay and straw containing dust can initiate inflammation in the lower airways (Fairbairn et al 1993).…”

Section: Resultsmentioning

confidence: 99%

Nocardia nova identification in a transtracheal wash of a horse with recurrent airway obstruction

et al. 2015

View full text Add to dashboard Cite

Recurrent airway obstruction (RAO) in horses is characterized by IFN-γ and IL-8 production in bronchoalveolar lavage cells

Cited by 129 publications

References 30 publications

A comparison of nanoparticulate CpG immunotherapy with and without allergens in spontaneously equine asthma‐affected horses, an animal model

A comparison of nanoparticulate CpG immunotherapy with and without allergens in spontaneously equine asthma‐affected horses, an animal model

Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction

Nocardia nova identification in a transtracheal wash of a horse with recurrent airway obstruction

Contact Info

Product

Resources

About