Recurrent aphthous stomatitis and thiamine deficiency

Haisraeli-Shalish, Miri; Livneh, Avi; Katz, Joseph; Doolman, Ram; Sela, Ben‐Ami

doi:10.1016/s1079-2104(96)80437-9

Cited by 34 publications

(12 citation statements)

References 13 publications

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“…The prevalence of iron, folic acid and vitamin B12 deficiencies and their role in the pathophysiology of recurrent aphthous stomatitis is not well known, although several reports have considered their importance and relevance 1–3 . It has also been reported that there is an association between thiamine (vitamin B1) deficiency and recurrent aphthous stomatitis 4 . Porter et al .…”

Section: Discussionmentioning

confidence: 99%

Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis

Pişkin¹,

Sayan²,

Durukan³

et al. 2002

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis

Pişkin¹,

Sayan²,

Durukan³

et al. 2002

Acad Dermatol Venereol

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“…The present evidence thus suggests that some patients with RAS may have deficiency of one or more haematinics, or occasionally an unrelated vitamin. That these deficiencies are truly important in the pathogenesis of RAS however, seems doubtful, as current data suggest that iron or vitamin supplement significantly only infrequently produce resolution of RAS (Nolan et al , 1991; Porter et al , 1992a; Haisraeli‐Shalish et al , 1996).…”

Section: Systemic Factors Predisposing To Rasmentioning

confidence: 96%

“…Deficiencies in vitamin B 1 (thiamine), B 2 and B 6 were observed in 28.2% of a group of patients with RAS from Scotland (Nolan et al , 1991), but the cause of the deficiencies was never established, and it is interesting to note, that this group of workers found vitamin B complex deficiencies in other patients with quite disparate clinical disease. Low levels of thiamine were observed in substantial number of adult patients from Israel with RAS (Haisraeli‐Shalish et al , 1996). The reasons why thiamine deficiency could cause RAS are not known.…”

Section: Systemic Factors Predisposing To Rasmentioning

confidence: 99%

Number VI Recurrent aphthous stomatitis

et al. 2005

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Recurrent aphthous stomatitis (RAS; aphthae; canker sores) is a common condition which is characterized by multiple recurrent small, round or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow or grey floors typically presenting first in childhood or adolescence. RAS occurs worldwide although it appears most common in the developed world. The aetiology of RAS is not entirely clear. Despite many studies trying to identify a causal microorganism, RAS does not appear to be infectious. A genetic predisposition is present, as shown by strong associations with genotypes of IL-1beta; IL-6 in RAS patients, and a positive family history in about one-third of patients with RAS. Haematinic deficiency is found in up to 20% of patients. Cessation of smoking may precipitate or exacerbate RAS in some cases. Ulcers similar to RAS may be seen in human immunodeficiency virus disease and some other immune defects, and drugs, especially non-steroidal anti-inflammatory drugs and nicorandil may produce lesions clinically similar to RAS. Topical corticosteroids can often control RAS. However, the treatment of RAS remains unsatisfactory, as most therapies only reduce the severity of the ulceration and do not stop recurrence.

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“…In research by Lalla et al (2012), Nolan et al (1991a, b), Porter et al (1992) and Haisraeli-Shalish et al (1996), the supplementation of lacking microelements modified the disease course only in a small percentage of patients. Contrary, Volkov et al (2009) observed positive effects of the oral vitamin B12 supplementation in RAS subjects regardless of the initial serum levels of this microelement.…”

Section: Food Allergies and Microelement Deficienciesmentioning

confidence: 98%

Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects: Literature Review

Ślebioda

Szponar

Kowalska

2013

Arch. Immunol. Ther. Exp.

220

182

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Recurrent aphthous stomatitis (RAS; recurrent aphthous ulcers; canker sores) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. Up to now, the etiopathogenesis of this condition remains unclear; it is, however, considered to be multifactorial. The results of currently performed studies indicate that genetically mediated disturbances of the innate and acquired immunity play an important role in the disease development. Factors that modify the immunologic response in RAS include: food allergies, vitamin and microelement deficiencies, hormonal and gastrointestinal disorders (e.g., celiac disease, Crohn’s disease, ulcerative colitis), some viral and bacterial infections, mechanical injuries and stress. In this paper, we presented the main etiopathogenetic factors of RAS with a special emphasis on the mechanisms of the immune response modification. Moreover, we discussed the crucial clinical symptoms and types of RAS together with epidemiologic data based on the current medical literature reports and our own observations.

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Recurrent aphthous stomatitis and thiamine deficiency

Cited by 34 publications

References 13 publications

Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis

Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis

Number VI Recurrent aphthous stomatitis

Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects: Literature Review

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