2009
DOI: 10.3201/eid1507.080716
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Recurrent Lymphocytic Meningitis Positive for Herpes Simplex Virus Type 2

Abstract: We found the prevalence of recurrent lymphocytic meningitis associated with herpes simplex virus type 2 (HSV-2) was 2.2/100,000 population in Finland during 1996–2006, higher than previous estimates. PCR was most sensitive in detecting HSV-2 DNA from cerebrospinal fluid if the sample was taken 2–5 days after symptom onset.

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Cited by 40 publications
(28 citation statements)
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“…The incidence of HSV-2 meningitis has probably been underestimated (2,10,17) and may increase in the future. Although local immune responses in CNS may be different to responses in peripheral blood, our data provide new information on the agent-host interaction in recurrent HSV-2 meningitis and may be valuable for designing future strategies for antiviral and/or immunological treatment of patients with this disease.…”
Section: Discussionmentioning
confidence: 99%
“…The incidence of HSV-2 meningitis has probably been underestimated (2,10,17) and may increase in the future. Although local immune responses in CNS may be different to responses in peripheral blood, our data provide new information on the agent-host interaction in recurrent HSV-2 meningitis and may be valuable for designing future strategies for antiviral and/or immunological treatment of patients with this disease.…”
Section: Discussionmentioning
confidence: 99%
“…At the same time, as the analysis of the world scientific and medical literature shows, in 84 % of cases, the etiologic factor of BRAM is HSV type 2 [1,13,14]. In this regard, it should be noted that the reactivation of HSV type 2 persisting in the sensory ganglia of the lumbosacral spinal cord can also cause combined, but already uroneurological pathology in the form of Elsberg syndrome (Charles Albert Elsberg, 1871-1948), which is manifested as radiculomyelitis (pain/ numbness/paresthesia in the buttocks, perineum or legs) in combination with acute urinary retention [12].…”
Section: Diagnostic Criteria For the Diagnosis Of Mollaret Meningitismentioning
confidence: 99%
“…Benign recurrent lymphocytic meningitis, or Mollaret meningitis (MM), is a disease characterized by headache, fever and vomiting; in 84 % of cases, it is caused by the reactivation of type 2 herpes simplex virus (HSV) with or without genital rashes [1].…”
Section: Introductionmentioning
confidence: 99%
“…Аналіз опублікованих випадків менінгіту Молларе свідчить, що захворювання переважно зустрічається в до-рослих [4,5,12,13]. Є лише поодинокі повідомлення про захворювання в дітей.…”
Section: обговоренняunclassified
“…Проте опубліковані випадки, особливо після впровадження методики ПЛР, свідчать про високу частоту асоціації даного захворювання з ві-русами простого герпесу, зокрема HSV 2 [12,13]. У хво-рої в нашому дослідженні під час останніх трьох епізо-дів у спиномозковій рідині виявлялась ДНК HSV 1/2.…”
Section: обговоренняunclassified