Recurrent recurrence of positive SARS-CoV-2 RNA in a COVID-19 patient

Cao, Shugang; Wu, Aimei; Li, Jiaxia; Li, Yuancheng; Xia, Mingwu; Wu, Juncang

doi:10.21203/rs.3.rs-23197/v1

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Scientific studies on the alleged SARS-CoV-2 reinfection phenomenon are scarce. There are isolated case reports describing a situation in which a single COVID-19 patient was discharged, in part because of two consecutive negative SARS-CoV-2 RT-qPCR clinical results, but retested positive for SARS-CoV-2 RNA during convalescence ( 15 – 19 ), including a 71-year-old woman who tested positive for 60 days from the onset of symptoms (55 days from her first positive test) ( 20 ). Other accounts detail similar results for small cohorts of 2 or more individuals ( 21 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints

Gunawardana

Breslin

Cortez

et al. 2021

mSphere

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Section: Discussionmentioning

confidence: 99%

Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints

Gunawardana

Breslin

Cortez

et al. 2021

mSphere

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“…18 19 Doubtfulness about the efficiency and safety of the COVID-19 vaccine as well as the longevity of its immunity is evident in many countries, which results in hesitancy. [20][21][22] Understanding the anticipated acceptability of COVID-19 vaccination and the barriers to uptake is important given the growing availability of COVID-19 vaccines. Until 5 January 2022, around 50.3% of the world's population was fully vaccinated, while only 1.4% of Ethiopia's population was fully vaccinated.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

“…Additionally, myths and incorrect assertions about vaccines, and a lack of general understanding of the disease were among the causes of vaccine hesitation 18 19. Doubtfulness about the efficiency and safety of the COVID-19 vaccine as well as the longevity of its immunity is evident in many countries, which results in hesitancy 20–22…”

Section: Introductionmentioning

confidence: 99%

COVID-19 vaccine acceptance and associated factors among adult clients at public hospitals in eastern Ethiopia using the health belief model: multicentre cross-sectional study

et al. 2023

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ObjectiveImmunization is still one of the best ways to reduce viral-related morbidity and mortality . Therefore, this study aimed to assess COVID-19 vaccine acceptance and associated factors among adult clients at public hospitals in Eastern Ethiopia.MethodA multicentred facility-based cross-sectional study design was utilised. The systematic random sampling technique was used to select 420 study participants. The characteristics of individuals were described using descriptive statistical analysis such as frequency, median and IQR. Mean was used for health belief model components. The association was assessed using bivariate and multivariable logistic regression and described by the OR along with a 95% CI. Finally, a p-value<0.05 in the adjusted analysis was used to declare a significant association.Outcome measureCOVID-19 vaccine acceptance and associated factors.ResultA total of 412 adult clients were interviewed, with a response rate of 98.1%. Of the total study participants, 225 (54.6%; 95% CI: 50.0% to -59.7%) were willing to accept the COVID-19 vaccine. Age≥46 (adjusted OR, AOR=3.64, 95% CI: 1.35- to 9.86), college and above level of education (AOR=2.50, 95% CI: 1.30- to 4.81), having health insurance (AOR=1.79, 95% CI: 1.11- to 2.87) and experiencing chronic disease (AOR=1.96, 95% CI: 1.02- to 3.77) were predictor variables. Also, components of the health belief model were significantly associated with COVID-19 vaccine acceptance.ConclusionCOVID-19 vaccine acceptance among the adult population was low compared to other study. Factors associated with COVID-19 vaccine acceptance were age, college and above level of education, having a chronic disease, having health insurance, perceived susceptibility, perceived severity, perceived benefit and perceived barrier.Improving awareness about COVID-19 among all sections of the population is crucial to improving vaccine acceptability.

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“…The copyright holder for this preprint this version posted July 28, 2020. ; https://doi.org/10.1101/2020.07.25.20160812 doi: medRxiv preprint single COVID-19 patient was discharged, in part because of two consecutive negative SARS-CoV-2 RT-qPCR clinical test results, but re-tested positive for SARS-CoV-2 RNA during convalescence [22][23][24][25][26], including a 71-year old woman who tested positive for 60 days from the onset of symptoms (55 days from her first positive test) [27]. Other accounts detail similar results for small cohorts of 2 or more individuals [28,29].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints

Gunawardana

Breslin

Cortez

et al. 2020

Preprint

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Background The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated coronavirus disease 2019 (COVID-19) have precipitated a global pandemic heavily challenging our social behavior, economy, and healthcare infrastructure. Public health practices currently represent the primary interventions for managing the spread of the pandemic. We hypothesized that frequent, longitudinal workplace disease surveillance would represent an effective approach to controlling SARS-CoV-2 transmission among employees and their household members, reducing potential economic consequences and loss of productivity of standard isolation methods, while providing new insights into viral-host dynamics. Methodology and Findings On March 23, 2020 a clinical study (OCIS-05) was initiated at a small Southern California organization. Results from the first 3 months of the ongoing study are presented here. Study participants (27 employees and 27 household members) consented to provide frequent nasal or oral swab samples that were analyzed by RT-qPCR for SARS-CoV-2 RNA using CDC protocols. Only participants testing negative were allowed to enter the "safe zone" workplace facility. Optional blood samples were collected at baseline and throughout the 3-month study. Serum virus-specific antibody concentrations (IgG, IgM, and IgA) were measured using a selective, sensitive, and quantitative ELISA assay developed in house. A COVID-19 infection model, based on traditional SEIR compartmental models combined with Bayesian non-linear mixed models and modern machine learning, was used to predict the number of employees and household members who would have become infected in the absence of workplace surveillance. Two study participants were found to be infected by SARS-CoV-2 during the study. One subject, a household member, tested positive clinically by RT-qPCR prior to enrollment and experienced typical COVID-19 symptoms that did not require hospitalization. While on study, the participant was SARS-CoV-2 RNA positive for at least 71 days and had elevated virus-specific antibody concentrations (medians: IgM, 9.83 ug mL-1; IgG, 11.5 ug mL-1; IgA, 1.29 ug mL-1) in serum samples collected at three timepoints. A single, unrelated employee became positive for SARS-CoV-2 RNA over the course of the study, but remained asymptomatic with low associated viral RNA copy numbers. The participant did not have detectable serum IgM and IgG concentrations, and IgA concentrations decayed rapidly (half-life: 1.3 d). The employee was not allowed entry to the safe zone workplace until testing negative three consecutive times over 7 d. No other employees or household members contracted COVID-19 over the course of the study. Our model predicted that under the current prevalence in Los Angeles County without surveillance intervention, up to 7 employees (95% CI = 3-10) would have become infected with at most 1 of them requiring hospitalizations and 0 deaths. Conclusions Our clinical study met its primary objectives by using intense longitudinal testing to provide a safe work environment during the COVID-19 pandemic, and elucidating SARS-CoV-2 dynamics in recovering and asymptomatic participants. The surveillance plan outlined here is scalable and transferrable. The study represents a powerful example on how an innovative public health initiative can be dovetailed with scientific discovery.

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Recurrent recurrence of positive SARS-CoV-2 RNA in a COVID-19 patient

Cited by 5 publications

References 7 publications

Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints

Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints

COVID-19 vaccine acceptance and associated factors among adult clients at public hospitals in eastern Ethiopia using the health belief model: multicentre cross-sectional study

Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints

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