Recurrent Spinal Cord Attacks in a Patient with a Limited Form of Neuromyelitis Optica

Matsumoto, Hideyuki; Shimizu, Takahiro; Okabe, Shingo; Konoma, Yuko; Takahashi, Toshiyuki; Hirakawa-Yamada, Minako; Igeta, Yukifusa; Hashida, Hideji

doi:10.2169/internalmedicine.50.4430

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…Furthermore, the atrophied cord lesions on the follow-up MRI were likely to reflect tissue rarefaction and neuronal loss as a result of intense edema associated with astrocytes injury. Frequent relapses at the same upper spinal cord area in patients with NMOSD were reported as seen in our cases ( 10 , 14 ). Cavitation and frequent relapses at the same upper spinal cord may be characteristic findings of cord lesions in NMOSD.…”

Section: Discussionsupporting

confidence: 80%

Three cases of neuromyelitis optica spectrum disorder

Matsusue

Fujihara

Suto

et al. 2016

Acta Radiologica Open

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Neuromyelitis optica (NMO) is characterized by attacks of optic neuritis and longitudinally extensive transverse myelitis. Cases positive for aquaporin 4 antibodies are classified to NMO spectrum disorder (NMOSD) which includes cases with optic neuritis, transverse myelitis, or with brain lesions typical of NMO. Our three cases with NMO/NMOSD revealed five imaging features: (i) extensive transverse cord lesions, extending more than three vertebral segments, partially persisting as cavitation; (ii) periependymal lesions; (iii) lesions of the corticospinal tracts; (iv) extensive and confluent hemispheric white matter lesions reflecting vasogenic edema and partially involving the cerebral cortices and basal ganglia; and (v) two patterns of serial hemispheric white matter lesions: one is cavitation and another is partial regression or disappearance. Cavitations, in the upper spinal cord and hemispheric white matter, are considered to be caused by severe vasogenic edema and are likely to be one of the characteristic findings in NMOSD.

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Section: Discussionsupporting

confidence: 80%

Three cases of neuromyelitis optica spectrum disorder

Matsusue

Fujihara

Suto

et al. 2016

Acta Radiologica Open

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show abstract

“…9 Patients present with signs of white matter dysfunction such as spasticity, hyperreflexia and a positive Babinski sign. [72][73][74] Mild muscle wasting along with pyramidal tract signs, a mixed picture of gray and white matter dysfunction, has been reported. 13 A study of myelitis in SLE revealed that patients with clinical "white matter" myelitis were more likely to fulfill NMO criteria than those with "gray matter" myelitis.…”

Section: Transverse Myelitismentioning

confidence: 99%

“…15,77 Recurrent transverse myelitis, commonly seen in NMO, 30 can occur in the same location in the spinal cord. 74 A progressive course is unusual but still possible. For example, in one report a NMO-IgG seropositive female experienced a 4-month history of progressive quadriplegia and respiratory failure following nausea, vomiting, and hiccupping.…”

Section: Transverse Myelitismentioning

confidence: 99%