Recurring déjà vu associated with 5-hydroxytryptophan

Kalra, Seema; Chancellor, Andrew; Zeman, Adam

doi:10.1111/j.1601-5215.2007.00245.x

Cited by 15 publications

(11 citation statements)

References 11 publications

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“…With such extreme déjà experiences, it is possible to isolate the memory deficit using experimental tasks [68]. A few other cases have been reported with the same classification in their descriptions (e.g., [69]).…”

Section: Déjà Vu and Déjà Vécumentioning

confidence: 99%

Déjà Experiences in Temporal Lobe Epilepsy

Illman

Butler

Souchay

et al. 2012

Epilepsy Research and Treatment

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Historically, déjà vu has been linked to seizure activity in temporal lobe epilepsy, and clinical reports suggest that many patients experience the phenomenon as a manifestation of simple partial seizures. We review studies on déjà vu in epilepsy with reference to recent advances in the understanding of déjà vu from a cognitive and neuropsychological standpoint. We propose a decoupled familiarity hypothesis, whereby déjà vu is produced by an erroneous feeling of familiarity which is not in keeping with current cognitive processing. Our hypothesis converges on a parahippocampal dysfunction as the locus of déjà vu experiences. However, several other temporal lobe structures feature in reports of déjà vu in epilepsy. We suggest that some of the inconsistency in the literature derives from a poor classification of the various types of déjà experiences. We propose déjà vu/déjà vécu as one way of understanding déjà experiences more fully. This distinction is based on current models of memory function, where déjà vu is caused by erroneous familiarity and déjà vécu by erroneous recollection. Priorities for future research and clinical issues are discussed.

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Section: Déjà Vu and Déjà Vécumentioning

confidence: 99%

Déjà Experiences in Temporal Lobe Epilepsy

Illman

Butler

Souchay

et al. 2012

Epilepsy Research and Treatment

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“…Clinical reports of persistent and debilitating forms of the déjà experience have been made of those with dementia, temporal lobe epilepsy, migraine and schizophrenia (Kalra, Chancellor, & Zeman, 2007;Moulin et al, 2005;Neppe, 1983;Sacks, 1970), but it is not clear whether these experiences are déjà vu or déjà vécu, since the case descriptions and neuropsychological examination often provide insufficient detail to make this distinction.…”

Section: Deja Vu and Deja Vecumentioning

confidence: 99%

“…Deja vécu is reported with other aetiologies, for example, where a patient had received 5-hydroxytryptophan in combination with carbidopa, as treatment for palatal tremor (distressing, repetitive and involuntary movements of the soft palate; Kalra et al, 2007). Her account also indicates that novelty is possibly a trigger: I … was a little freaked out when I watched TV as I felt I was watching repeats, although I knew I wasn't, as it was the news.…”

Section: Novelty: On the Triggers Of Déjà Vécumentioning

confidence: 99%

Novel insights into false recollection: A model of déjà vécu

O'Connor

Lever

Moulin

2010

Cognitive Neuropsychiatry

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The thesis of this paper is that déjà experiences can be separated into two forms: déjà vu, arising from the erroneous sensation of familiarity, and déjà vécu, arising from the erroneous sensation of recollection. We summarise a series of cases for whom déjà vécu is experienced frequently and for extended periods, and seek to differentiate their experiences from 'healthy' déjà experiences by non-brain-damaged participants. In reviewing our cases, we stress two novel ideas: that déjà vécu in these cases is delusion-like; and that these cases experience déjà vécu for stimuli that are especially novel or unusual. Here we present a novel cognitive neuroscientific hypothesis of déjà vécu. This hypothesis assumes that the signal of retrieval from memory is neurally dissociable from the contents of retrieval. We suggest that a region downstream of the hippocampus signals

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“…So far, they have been used to speculate on the dopaminergic (Taiminen & Jääskeläinen, 2001) and serotonergic (Kalra, Chancellor & Zeman, 2007) mechanisms of the experience. They have also provided insights into patterns of recollective experience associated with déjà vecu The persistence of erroneous familiarity 7 population, many of whom experience déjà vu as an aura.…”

Section: Challenging Perceptual Theories Of Déjà Vu Activationmentioning

confidence: 99%

The persistence of erroneous familiarity in an epileptic male: Challenging perceptual theories of déjà vu activation

O'Connor

Moulin

2008

Brain and Cognition

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We report the case of a 39 year-old, temporal lobe epileptic male, MH. Prior to complex partial seizure, experienced up to three times a day, MH often experiences an aura experienced as a persistent sensation of déjà vu. Data-driven theories of déjà vu formation suggest that partial familiarity for the perceived stimulus is responsible for the sensation.Consequently, diverting attention away from this stimulus should cause the sensation to dissipate. MH, whose sensations of déjà vu persist long enough for him to shift his perceptual focus a number of times during the experience, spontaneously reports that these shifts make no difference to the sensation experienced. This novel observation challenges data-driven theories of déjà vu formation which have been used to explain the occurrence of déjà vu in those with temporal lobe epilepsy and the general population. Clearly, in epilepsy, erratic neuronal firing is the likely contributor, and in this paper we postulate that such brain firing causes higher-order erroneous 'cognitive feelings'. We tentatively extend this account to the general population. Rather than being a reaction to familiar elements in perceptual stimuli, déjà vu is likely to be the result of a cognitive feeling borne of the erroneous activation of neural familiarity circuits such as the parahippocampal gyrus, persisting as long as this activation persists.

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Recurring déjà vu associated with 5-hydroxytryptophan

Abstract: The serotonergic system is involved in the genesis of déjà vu.

Cited by 15 publications

References 11 publications

Déjà Experiences in Temporal Lobe Epilepsy

Déjà Experiences in Temporal Lobe Epilepsy

Novel insights into false recollection: A model of déjà vécu

The persistence of erroneous familiarity in an epileptic male: Challenging perceptual theories of déjà vu activation

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