The Neoproterozoic granites along the western margin of the Yangtze Block are crucial for understanding the evolution of the Rodinia supercontinent and crust–mantle interaction. Based on a regional geological survey, this study analyses the zircon U–Pb geochronology, Lu–Hf isotope, whole‐rock Sr–Nd isotopes, and geochemistry of the Maoniushan granites along the western margin of the Yangtze Block and discusses the Neoproterozoic tectonic evolution history of the Mianning–Maoniushan belt. The results show that the Maoniushan granites belong to calc‐alkaline weak peraluminous monzogranite. The granites are enriched in large‐ion lithophile elements (i.e., Rb, Sr, Cs, and Ba) but relatively depleted in high‐field‐ strength elements (i.e., Nb, Ta, U, and Th). The zircon saturation temperature (TZr) ranges from 628 to 766°C, and the weighted average 206Pb/238U ages of zircon range from 771 ± 30 to 759 ± 26 Ma. The εHf(t) values range from −2.0 to +7.2, with TDM2 model ages ranging from 1,797 to 1,208 Ma. The whole‐rock Sr–Nd isotopic data show (87Sr/86Sr)i ratios of 0.7039–0.7093, and the εNd(t) values range from +1.25 to +1.76 with TDM2 model ages ranging from 1,303 to 1,344 Ma. These findings indicate the presence of deep Mesoproterozoic crustal materials in the source area. The Maoniushan monzogranites belong to I‐type granite, which is formed by the partial melting of the basic rocks and pelites in the ancient lower crust due to the metasomatism of fluids from the subducted oceanic crust. The Maoniushan monzogranites may be formed in the process of transformation from regional thickening to thinning under the oceanic crust subduction setting.