Red alga polysaccharides attenuate angiotensin II-induced inflammation in coronary endothelial cells

Hamias, Rachel; Wolak, Talya; Huleihel, Mahmoud; Paran, Esther; Levy‐Ontman, Oshrat

doi:10.1016/j.bbrc.2018.04.206

Cited by 9 publications

(5 citation statements)

References 32 publications

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“…When HCAECs were pre-treated with PSs (500 µg/mL) under Ang II induction, PSs were able to down-regulate the NF-kB activation and suppress adhesion molecule ICAM-1 and VCAM-1 up-regulation in a dose-dependent manner. Furthermore, polysaccharides enhanced nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) production, and reduced ET-1 expression levels [28].…”

Section: Polysaccharidesmentioning

confidence: 99%

Marine Microalgal Products with Activities against Age-Related Cardiovascular Diseases

Yurika,

Montuori,

Lauritano

2024

Marine Drugs

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Heart disease is one of the leading causes of death worldwide, and it is estimated that 17.9 million people die of it each year. The risk factors for cardiovascular diseases are attributable to an unhealthy and sedentary lifestyle, poor nutrition, stress, genetic predisposition, diabetes, obesity, and aging. Marine microalgae have been the subject of numerous studies for their potential activity against several human diseases. They produce a plethora of primary and secondary metabolites such as essential nutrients, vitamins, pigments, and omega-3 fatty acid. Many of these molecules have antioxidant properties and have been shown to play a role in the prevention of heart diseases. The aim of this review is to summarize recent studies on the discovery of marine microalgal compounds and bioactivities for cardiovascular diseases, including in vitro and in vivo studies, showing and discussing recent discoveries and trends. The most promising results were found for microalgal polysaccharides, peptides and carotenoids. In conclusion, the overall data summarized here show that microalgae-based supplementation has the potential to improve age-related cardiovascular diseases and we expect more clinical studies in the future.

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Section: Polysaccharidesmentioning

confidence: 99%

Marine Microalgal Products with Activities against Age-Related Cardiovascular Diseases

Yurika,

Montuori,

Lauritano

2024

Marine Drugs

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“…Isolated compounds classified as polysaccharides by the authors revealed several anti-inflammatory properties, namely the degranulation of basophils inhibition (Chondrus verrucosus ( [114]), the reduction of paw edema (Porphyra vietnamensis [115], Digenia simplex [116]) and leukocyte infiltrations (D. simplex [116]), the inhibition of IL-1β, TNF-α (D. simplex [116]; Gracilaria lemaneiformis [117]), NO, PGE2, COX-2 and ROS (Gracilaria lemaneiformis [117]) production, and NF-κB expression (Porphyridium sp. [118]). Furthermore, cellulose microfibril from Gelidium amansii lead to JNK1/2 and p38 inhibition [119], and cellulose nanocrystals from the same seaweed revealed COX-2 and ERK1/2 inhibition [120].…”

Section: Anti-inflammatory Extracts and Compounds From Red Macroalgaementioning

confidence: 99%

Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Januário

Félix

et al. 2021

Pharmaceutics

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Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

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“…In cholesterol crystals-pretreated macrophage-like THP-1 cells, treatment with Chayote polysaccharides reduced intracellular lipids levels by up-regulating the expression of liver X receptor alpha (LXR α ), and also inhibited the activation of inflammasome NLRP3 ( Castro-Alves et al, 2019 ). Additionally, Red alga polysaccharides inhibited the activation of NF-κB and the up-regulation of intercellular vascular cell adhesion molecule-1 (VCAM-1) as well as adhesion molecule-1 (ICAM-1) in human coronary artery endothelial cells (HCAECs) induced by angiotensin II ( Hamias et al, 2018 ) or TNF- α ( Levy-Ontman et al, 2017 ), which is helpful for alleviating inflammatory atherosclerosis progression. In addition, Opuntia dillenii Haw.…”

Section: Protective Effects Of Plant Polysaccharides On Cardiovascular Systemmentioning

confidence: 99%

Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Dong

Zhou

et al. 2021

Front. Pharmacol.

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Cardiovascular disease is a kind of heart, brain, and blood vessel injury disease by the interaction of various pathological factors. The pathogenesis of cardiovascular disease is complex with various risk factors, including abnormally elevated blood pressure, glucose, and lipid metabolism disorders, atherosclerosis, thrombosis, etc. Plant polysaccharides are a special class of natural products derived from plant resources, which have the characteristics of wide sources, diverse biological activities, and low toxicity or side effects. Many studies have shown that plant polysaccharides improve cardiovascular diseases through various mechanisms such as anti-oxidative stress, restoring the metabolism of biological macromolecules, regulating the apoptosis cascade to reduce cell apoptosis, and inhibiting inflammatory signal pathways to alleviate inflammation. This article reviews the pharmacological effects and protective mechanisms of some plant polysaccharides in modulating the cardiovascular system, which is beneficial for developing more effective drugs with low side effects for management of cardiovascular diseases.

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Red alga polysaccharides attenuate angiotensin II-induced inflammation in coronary endothelial cells

Cited by 9 publications

References 32 publications

Marine Microalgal Products with Activities against Age-Related Cardiovascular Diseases

Marine Microalgal Products with Activities against Age-Related Cardiovascular Diseases

Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care

Cardiovascular Protective Effects of Plant Polysaccharides: A Review

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