Red cell distribution width and end-organ damage in patients with systo-diastolic hypertension

Abstract

IntroductionBoth end-organ damage and high red cell distribution width (RDW) values are associated with adverse cardiovascular events, inflammatory status, and neurohumoral activation in hypertensive disease and in the general population. In this study, we investigated the relationship between RDW and end-organ damage in hypertensive patients.Material and methodsThe 446 systo-diastolic hypertensive patients included in the study received 24-hour ambulatory blood pressure monitoring. Left ventricular mass index, glomerular filtration rate, and microalbuminuria were measured to identify end-organ damage. High-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels of all patients were also examined.ResultsThe mean age of the participants was 49.96 ±11.04 years. The mean RDW was 13.06 ±1.05%. Red cell distribution width was positively correlated with left ventricular myocardial index (LVMI), urinary albumin, hs-CRP, and NT-proBNP (r = 0.298, p < 0.001; r = 0.228, p < 0.001; r = 0.337, p < 0.001; r = 0.277, p < 0.001, respectively), while RDW was negatively correlated with eGFR (r = –0.153, p < 0.001). Additionally, while there was a positive correlation between RDW and 24-h systolic blood pressure, no correlation was found between RDW and 24-h diastolic blood pressure (r = 0.132, p = 0.006 and r = 0.017, p = 0.725, respectively). Multiple linear regression analysis revealed that RDW levels were independently associated with eGFR, LVMI, and severity of albuminuria (β = 0.126, p = 0.010; β = –0.149, p = 0.002; β = 0.114, p = 0.035).ConclusionsHigh RDW levels in systo-diastolic hypertensive patients were found to be an independent predictor of end-organ damage.

Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension

“… 27 In the present study, we assessed the NLR and RDW. In a study of patients with systo-diastolic hypertension, Pusuroglu et al 28 found that an increased RDW was related to end-organ damage (increased LV mass index, glomerular filtration rate, and urinary albumin concentration). However, their study included no control group.…”

Red cell distribution width in coronary heart disease: prediction of restenosis and its relationship with inflammatory markers and lipids

“…There are multiple other factors, such as vascular damage caused by stent placement, local and systemic inflammatory responses induced by stent implantation and of coronary lesion severity, that may also affect stent restenosis. The red cell distribution width (RDW), which is commonly used to evaluate anaemia, has emerged as a new cardiovascular prognostic marker, and increased RDW values have been shown in patients with heart failure,8 coronary events,9 10 paroxysmal atrial fibrillation11 and end-organ damage with systolic-diastolic hypertension 12. In this retrospective study, we analysed the RDW, clinical features, serological indexes and coronary angiography results to determine the risk factors for ISR and provided a theoretical basis for preventive stent restenosis treatment after PCI.…”

Red cell distribution width may help to discriminate synthetic cannabinoid users in the emergency department

“…Increased RDW levels were identified as independent predictors of the increase in left ventricular myocardial index, decrease in glomerular filtration rate values and correlated with 24-h systolic blood pressure. 8 The most frequent cardiovascular effects of SC include hypertension and tachycardia. However, effects such as bradycardia and hypotension were also reported.…”