Red-luminescent europium (III) doped silica nanoshells: synthesis, characterization, and their interaction with HeLa cells

Yang, Jian; Sandoval, Sergio; Alfaro, Jesus G.; Aschemeyer, Sharraya; Liberman, Alex; Martín, David; Makale, Milan; Kummel, Andrew C.; Trogler, William C.

doi:10.1117/1.3593003

Cited by 18 publications

(29 citation statements)

References 31 publications

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“…In order to overcome some shortcomings of fluorescently labeled silica nanoparticles, such as photobleaching and compromised surface properties, Yang et al integrated a small amount of Eu 3 + into the silica shells which allowed for the shells to become photoluminescent [86]. By using Eu(NO 3 ) 3 during the sol–gel growth process, the nanoparticles had an excitation at 415 nm and an emission of 620 nm, which could also be imaged by 2-photon microscopy.…”

Section: Biomedical Imagingmentioning

confidence: 99%

Synthesis and surface functionalization of silica nanoparticles for nanomedicine

Liberman

Mendez

Trogler

et al. 2014

Surface Science Reports

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There are a wide variety of silica nanoformulations being investigated for biomedical applications. Silica nanoparticles can be produced using a wide variety of synthetic techniques with precise control over their physical and chemical characteristics. Inorganic nanoformulations are often criticized or neglected for their poor tolerance; however, extensive studies into silica nanoparticle biodistributions and toxicology have shown that silica nanoparticles may be well tolerated, and in some case are excreted or are biodegradable. Robust synthetic techniques have allowed silica nanoparticles to be developed for applications such as biomedical imaging contrast agents, ablative therapy sensitizers, and drug delivery vehicles. This review explores the synthetic techniques used to create and modify an assortment of silica nanoformulations, as well as several of the diagnostic and therapeutic applications.

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Section: Biomedical Imagingmentioning

confidence: 99%

Synthesis and surface functionalization of silica nanoparticles for nanomedicine

Liberman

Mendez

Trogler

et al. 2014

Surface Science Reports

Self Cite

420

255

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“…15,1617 The hollow silica NS are subjected to at least three cycles of vacuum desorption followed by perfluoropentane filling. The perfluoropentane gas filled NS are suspended in degassed water at a concentration of 4 mg/ml…”

Section: Methodsmentioning

confidence: 99%

Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model

Ward

Wang

Mendez

et al. 2016

The American Journal of Surgery

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INTRODUCTION We aimed to evaluate the potential for ultrasound (US) visible biodegradable nanoshells (NS) as an alternative to wire guided localization (WL) for non-palpable tumors in vivo. METHODS VX2 tumor was injected in bilateral thighs of 22 New Zealand rabbits and after 5-10 days one tumor was marked with a wire as a control and the contralateral tumor was injected with 1mL of 500 nm gas-filled silica NS under Doppler US. Tumors were excised after 24 hours. Chi square was utilized for significance, p=.05. RESULTS One rabbit was excluded on postoperative day 1 due to equipment failure, no ill effects were observed from the NS. The NS were utilized to localize and resect 100% of marked tissue, 4/21 wires were displaced (p<.05) . CONCLUSIONS We have shown that preoperatively injected US visible silica NS can be successfully utilized to mark non-palpable tumors in vivo more consistently than WL.

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“…This method was adapted from a published procedure by Yang et al 70 . All concentrations mentioned are added so the total volume in each well was 1 mL, unless stated otherwise.…”

Section: Methodsmentioning

confidence: 99%

Self-assembled targeting of cancer cells by iron(iii)-doped, silica nanoparticles

et al. 2014

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Iron(III)-doped silica nanoshells are shown to possess an in vitro cell-receptor mediated targeting functionality for endocytosis. Compared to plain silica nanoparticles, iron enriched ones are shown to be target-specific, a property that makes them potentially better vehicles for applications, such as drug delivery and tumor imaging, by making them more selective and thereby reducing the nanoparticle dose. Iron(III) in the nanoshells can interact with endogenous transferrin, a serum protein found in mammalian cell culture media, which subsequently promotes transport of the nanoshells into cells by the transferrin receptor-mediated endocytosis pathway. The enhanced uptake of the iron(III)-doped nanoshells relative to undoped silica nanoshells by a transferrin receptor-mediated pathway was established using fluorescence and confocal microscopy in an epithelial breast cancer cell line. This process was also confirmed using fluorescence activated cell sorting (FACS) measurements that show competitive blocking of nanoparticle uptake by added holo-transferrin.

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Red-luminescent europium (III) doped silica nanoshells: synthesis, characterization, and their interaction with HeLa cells

Cited by 18 publications

References 31 publications

Synthesis and surface functionalization of silica nanoparticles for nanomedicine

Synthesis and surface functionalization of silica nanoparticles for nanomedicine

Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model

Self-assembled targeting of cancer cells by iron(iii)-doped, silica nanoparticles

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