Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension

Pecháňová, Oľga; Bernátová, Iveta; Babál, Pavel; Martínez, María Carmen; Kyselá, S; Štvrtina, Svetoslav; Andriantsitohaina, Ramaroson

doi:10.1097/01.hjh.0000133734.32125.c7

Cited by 115 publications

(76 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, we showed that refreshed endothelium-dependent vasorelaxation was accompanied by the increased activity of NO-synthase in the left ventricle after the treatment with Provinols TM . Our results are in a good consensus with observations in the model of NO-deficient hypertension where the potentiation of the inhibited thoracic aorta vasorelaxation has been attributed to the activation of NO pathway by polyphenols (Bernátová et al 2002;Pecháňová et al 2004). Moreover, the increased production of NO due to stimulation of NO-synthase activity in arterial wall (also in aorta) due to the action of polyphenolic compounds has been confirmed by observations of our as well as other laboratories (Stocklet et al 1999;Zenebe et al 2001;Benito et al 2002).…”

Section: Discussionsupporting

confidence: 79%

“…Our previous experiments using the model of experimental hypertension demonstrated protective effects of red wine polyphenols on increased blood pressure, myocardial fibrosis, vascular wall remodeling and impaired arterial reactivity. Improved vascular function and structure in this model was associated with reduced oxidant status as well as with the increased NO production after activation of NOsynthase (Bernátová et al 2002;Pecháňová et al 2004).…”

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Red wine polyphenols correct vascular function injured by chronic carbon tetrachloride intoxication

Čačányiová¹,

Pecháňová²,

Babál³

et al. 2011

gpb

View full text Add to dashboard Cite

Abstract. The aim of the study was to evaluate the effect of red wine polyphenols extract Provinols TM on the development of cardiovascular injury in the model of carbon tetrachloride (CCl 4 ) intoxication. We followed the thoracic aorta vasoactivity and left ventricle nitric oxide (NO) synthase activity in male Wistar rats. In the preventive experiment lasting for 12 weeks the control group, the group receiving CCl 4 (0.5 ml/kg) two times a week subcutaneously, the group receiving Provinols TM (30 mg/kg/day) in drinking water and the group receiving CCl 4 +Provinols TM was used. In the recovery experiment, the initial 12 weeks of CCl 4 treatment were followed by 3 weeks of spontaneous recovery or recovery with Provinols TM . CCl 4 -intoxication resulted in the injury of vasoactivity which was demonstrated by the inhibition of acetylcholine-induced relaxation as well as noradrenaline-induced contraction. In the preventive as well as recovery experiment administration of polyphenols refreshed endotheliumdependent relaxant response and normalized inhibited contraction to adrenergic stimuli. Provinols TM treatment significantly increased NO-synthase activity in all groups. The results revealed beneficial effects of red wine polyphenols on vascular function injured by chronic CCl 4 intoxication. The correction of endothelial function seems to be attributed to the activation of NO pathway by polyphenols.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 92%

Red wine polyphenols correct vascular function injured by chronic carbon tetrachloride intoxication

Čačányiová¹,

Pecháňová²,

Babál³

et al. 2011

gpb

View full text Add to dashboard Cite

show abstract

“…The decreased eNOS protein expression in this study is likely due to the down-regulation of eNOS gene expression. On the other hand, other report showed that L-NAME induced an increased eNOS mRNA expression but that aortic NOS activity was, in fact, decreased (Pechanova et al 2004). It still could not readily explain the discrepancy of the levels of mRNA expression found in L-NAME-treated rats.…”

Section: Discussionmentioning

confidence: 70%

Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with l-NAME-induced hypertension

Nakmareong

Kukongviriyapan

Pakdeechote

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

140

128

View full text Add to dashboard Cite

Inhibition of nitric oxide synthesis with N ( ω )-nitro-L-arginine methyl ester (L-NAME) induces marked hypertension and oxidative stress. Curcumin (CUR) has been shown strong antioxidant property. Tetrahydrocurcumin (THU), a major metabolite of CUR, possesses several pharmacological effects similar to CUR; however, it is less studied than CUR. We investigated whether CUR and THU could prevent vascular dysfunction and inhibit development of hypertension in L-NAME-treated rats. Male Sprague-Dawley rats were administered with L-NAME (50 mg/kg/day) in drinking water for 3 weeks. CUR or THU (50 and 100 mg/kg/day) was fed to animals simultaneously with L-NAME. L-NAME administration induced increased arterial blood pressure and elevated peripheral vascular resistance accompanied with impaired vascular responses to angiotensin II and acetylcholine. CUR and THU significantly suppressed the blood pressure elevation, decreased vascular resistance, and restored vascular responsiveness. The improvement of vascular dysfunction was associated with reinstating the marked suppression of eNOS protein expression in the aortic tissue and plasma nitrate/nitrite. Moreover, CUR and THU reduced vascular superoxide production, decreased oxidative stress, and increased the previously depressed blood glutathione (GSH) and the redox ratios of GSH in L-NAME hypertensive rats. The antihypertensive and some antioxidant effects of THU are apparently more potent than those of CUR. This study suggests that CUR and THU prevented the development of vascular dysfunction induced by L-NAME and that the effects are associated with alleviation of oxidative stress.

show abstract

“…Rats were then divided randomly in six experimental groups as follows: the first group (n = 6) served as control and received tap water only. In the second group (L-NAME group, n = 6), L-NAME was added to drinking water at a concentration of 0.4 mg/ml to account for a daily intake of 40 mg/kg (Bernàtovà et al, 2002;Pechanova et al, 2004;Jendekova et al, 2006;Javorkova et al, 2007). The third group (AuL group, n = 8) received simultaneously L-NAME (40 mg/kg/day) and AuL extract at 250 mg/kg/day (Ziyyat and Boussairi, 1998).…”

Section: Model Of L-name-induced Arterial Hypertension and Experimentmentioning

confidence: 99%

“…The polyphenolic compounds have beneficial properties for preventing cardiovascular alterations in nitric oxide (NO) deficient hypertension (Bernàtovà et al, 2002;Pechanova et al, 2004;Curin and Andriantsitohaina, 2005;Perez-Vizcaino et al, 2006). This is the reason for our choice of the N Gnitro-l-arginine methyl-ester (L-NAME) experimental model of hypertension characterized by pronounced target organ damages.…”

Section: Introductionmentioning

confidence: 98%

Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats

Afkir

Nguelefack

Aziz

et al. 2008

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension

Cited by 115 publications

References 32 publications

Red wine polyphenols correct vascular function injured by chronic carbon tetrachloride intoxication

Red wine polyphenols correct vascular function injured by chronic carbon tetrachloride intoxication

Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with l-NAME-induced hypertension

Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats

Contact Info

Product

Resources

About