Objective. To assess the effects of a computer-free classroom on first-year Doctor of Pharmacy (PharmD) students' performance in a pathophysiology course. Methods. In the 2018 course offering, the instructor enforced an electronics-free classroom where students could not access computers to take notes during lectures. Data were compared to a previous iteration of the course in which students could use computers for notetaking if they desired. Four inclass examinations were given by the instructor and performance between the two student classes were compared.Results. The average examination grade increased 3% in the electronics-free classroom. Overall, final course grades were similar for students receiving A's and B's, but there was a notable increase in C's and a corresponding decrease in course failures. Course evaluations remained consistent and a slight majority of student comments were supportive of the computer-free environment. Conclusion. Student performance on examinations and in the course improved within the electronicsfree classroom, especially for students at the lower end of the grading scale. This work provides important insights for faculty and administrators as they weigh whether to create a computer-free learning environment.