Redox and Nitric Oxide-Mediated Regulation of Sensory Neuron Ion Channel Function

Gamper, Nikita; Ooi, Lezanne

doi:10.1089/ars.2014.5884

Cited by 66 publications

(45 citation statements)

References 234 publications

(253 reference statements)

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“…ROS and NO are oxidants in the Alzheimer’s brain. However, NO is also a neurotransmitter, which may protect synapses by increasing neuronal excitability [43,44]. Thus, whether the Aβ-induced increase in NO acts as a compensatory and neuroprotective or neurotoxic role is unclear.…”

Section: Discussionmentioning

confidence: 99%

An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35

et al. 2017

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Increased evidence suggests that marine unsaturated fatty acids (FAs) can protect neurons from amyloid-β (Aβ)-induced neurodegeneration. Nuclear magnetic resonance (NMR), high performance liquid chromatography (HPLC) and gas chromatography (GC) assays showed that the acetone extract 4-2A obtained from shrimp Pandalus borealis industry processing wastes contained 67.19% monounsaturated FAs and 16.84% polyunsaturated FAs. The present study evaluated the anti-oxidative and anti-inflammatory effects of 4-2A in Aβ25–35-insulted differentiated SH-SY5Y cells. Cell viability and cytotoxicity were measured by using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays. Quantitative PCR and Western blotting were used to study the expression of neurotrophins, pro-inflammatory cytokines and apoptosis-related genes. Administration of 20 μM Aβ25–35 significantly reduced SH-SY5Y cell viability, the expression of nerve growth factor (NGF) and its tyrosine kinase TrkA receptor, as well as the level of glutathione, while increased reactive oxygen species (ROS), nitric oxide, tumor necrosis factor (TNF)-α, brain derived neurotrophic factor (BDNF) and its TrkB receptor. Aβ25–35 also increased the Bax/Bcl-2 ratio and Caspase-3 expression. Treatment with 4-2A significantly attenuated the Aβ25–35-induced changes in cell viability, ROS, GSH, NGF, TrkA, TNF-α, the Bax/Bcl-2 ratio and Caspase-3, except for nitric oxide, BDNF and TrKB. In conclusion, 4-2A effectively protected SH-SY5Y cells against Aβ-induced neuronal apoptosis/death by suppressing inflammation and oxidative stress and up-regulating NGF and TrKA expression.

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Section: Discussionmentioning

confidence: 99%

An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35

et al. 2017

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“…Some of these ROS-mediated effects may oppose others. For example oxidation of KCNQ channels, which are widely expressed in vagal sensory neurons [74], causes increased ‘M-currents’, which would be expected to decrease neuronal excitability [70]. Here, I shall focus on those mechanisms that have been directly studied in airway nociceptive nerves.…”

Section: Sensitivity Of Airway Afferent Nerves To Rosmentioning

confidence: 99%

Role of reactive oxygen species and TRP channels in the cough reflex

Taylor‐Clark

2016

Cell Calcium

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The cough reflex is evoked by noxious stimuli in the airways. Although this reflex is essential for health, it can be triggered chronically in inflammatory and infectious airway disease. Neuronal transient receptor potential (TRP) channels such as ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) are polymodal receptors expressed on airway nociceptive afferent nerves. Reactive oxygen species (ROS) and other reactive compounds are associated with inflammation, from either NADPH oxidase or mitochondria. These reactive compounds cause activation and hyperexcitability of nociceptive afferents innervating the airways, and evidence suggests key contributions of TRPA1 and TRPV1.

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“…Furthermore, NO is a potent vasodilator and had the ability to increase vascular permeability and edema through changes in local blood flow (Gamper and Ooi, 2014). PMFA significantly inhibit the formation of NO 2 − , an oxidized form of NO released by LPS-activated macrophages.…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory action of Justicia acuminatissima leaves

Verdam

Guilhon-Simplicio

Barbosa

et al. 2015

Revista Brasileira de Farmacognosia

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BJP 122 1-5 Revista Brasileira de Farmacognosia xxx (2015) xxx-xxx w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c t In Amazonas State (Brazil), Justicia acuminatissima (Miq.) Bremek., Acanthaceae, leaf teas are used in folk medicine to treat several inflammatory illnesses. In order to validate this medicinal application, we analyzed the acute toxicity and antioxidant, antiedematogenic and antinociceptive potentials of an aqueous extract of this species, using culture cells and animal models. The aqueous extract did not cause toxic effects on human lymphocytes in high concentration (400 g/mL), neither on mice treated with high doses (5000 mg/kg) in an acute toxicity analysis by oral route, and also did not cause lesions in the gastric mucosa of animals treated with 300 mg/kg, which was the maximal dose used in the anti-inflammatory screening. The aqueous extract caused inhibition of inflammatory pain in formalin-induced paw licking test with all tested doses, 30, 100 and 300 mg/kg, and antiedematogenic activity at 100 and 300 mg/kg. Additionally, the aqueous extract presented statistically significant action on the release of nitric oxide by lipopolysaccharide-activated macrophages. These results and other previously observed preliminarily Q2 studies support the folk use of this species, and further investigation of its action mechanism by inhibition of COX-2 or related metabolite would be interesting.

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Redox and Nitric Oxide-Mediated Regulation of Sensory Neuron Ion Channel Function

Cited by 66 publications

References 234 publications

An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35

An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35

Role of reactive oxygen species and TRP channels in the cough reflex

Anti-inflammatory action of Justicia acuminatissima leaves

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