Redox-responsive phenyl-functionalized polylactide micelles for enhancing Ru complexes delivery and phototherapy

Nanoscale Self-Assemblies from Amphiphilic Block Copolymers as Proficient Templates in Drug Delivery

“…The development of PNIPAM-based thermally triggered BCP micelles as cargo for the sustainable release of drugs was scrutinized worldwide and PNIPAMbased BCP micelles as perspective candidates for drug delivery; i.e., PNIPAM-based BCP micelles form a hydrophilic shell below the LCST and a hydrophobic core above the LCST. (PChM-PNIPAM), constructed with poly(cholesteryl 6-methacryloyloxy hexanoate) (PChM), and PNIPAM blocks were designed as the hydrophobic core and hydrophilic shell of the micelles, respectively, with increasing temperature [48][49][50][51].…”

“…An enormous assortment of such photo-responsive systems, operating at a particular wavelength to accomplish on-demand drug release, has been reported. In particular, light-responsive BCPs have been of particular interest because of the specific interval and site controls that make them useful for prospective applications in controlled drug delivery systems and in forming self-healing, reversible wettability materials [48][49][50][51]. Also, such BCP-based nanocarriers are considered for the design of non-toxic treatment regimens that deal with spatiotemporal control beyond the release of captured therapeutic cargoes.…”

Polymeric encapsulation of a ruthenium(ii) polypyridyl complex: from synthesis to in vivo studies against high-grade epithelial ovarian cancer

“…The main hurdles encountered in the delivery of active payloads from biodegradable polymer matrices are low drug loadings, inconsistent encapsulation efficiencies and the fast, uncontrolled release from the matrix, particularly during the rst 12 h ('burst release'). 6,[9][10][11] These limitations are traditionally associated with physical encapsulation, the most common method of generating nanoparticles. Alternatively, novel encapsulation methodologies have been developed to overcome such limitations, where the payload is covalently attached to the polymer backbone.…”

Ruthenium(ii) polypyridyl complexes with visible light-enhanced anticancer activity and multimodal cell imaging

“…14,21 A series of drug delivery nanosystems have also been used to load ruthenium polypyridyl complexes for cancer treatment and bioimaging. 26–28…”

“…14,21 A series of drug delivery nanosystems have also been used to load ruthenium polypyridyl complexes for cancer treatment and bioimaging. [26][27][28] It is widely accepted that DNA is one of the major targets for most of the metal-based anticancer drugs. Specifically, the interactions of ruthenium-based anticancer complexes with DNA have been extensively studied.…”