Reduced binding of oxytocin in the rat brain during aging

Arsenijévic, Yvan; Dreifuss, Jean Jacques; Vallet, Philippe; Marguerat, Anouk; Tribollet, Eliane

doi:10.1016/0006-8993(95)01020-v

Cited by 38 publications

(24 citation statements)

References 17 publications

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“…Although, the highest densities of oxytocin receptors were observed in infant rat brain especially in cortex and spinal cord, low or undetectable numbers of oxytocin receptors were reported in the adult rat brain. It has been shown that aging decreases the number of oxytocin binding sites in the other part of brain (Arsenijevic et al, 1995). Besides its best known roles in parturition and lactation, oxytocin also plays important regulatory role in variety of physiological conditions such as social memory and attachment, sex and maternal behavior, and human bonding and trust (Gimpl and Fahrenholz, 2001; Lee et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides

Timur

Demir

Seyrantepe

2016

Front. Mol. Biosci.

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Lysosomal serine carboxypeptidase Cathepsin A (CTSA) is a multifunctional enzyme with distinct protective and catalytic function. CTSA present in the lysosomal multienzyme complex to facilitate the correct lysosomal routing, stability and activation of with beta–galactosidase and alpha-neuraminidase. Beside CTSA has role in inactivation of bioactive peptides including bradykinin, substances P, oxytocin, angiotensin I and endothelin-I by cleavage of 1 or 2 amino acid(s) from C-terminal ends. In this study, we aimed to elucidate the regulatory role of CTSA on bioactive peptides in knock-in mice model of CTSAS190A. We investigated the level of bradykinin, substances P, oxytocin, angiotensin I and endothelin-I in the kidney, liver, lung, brain and serum from CTSAS190A mouse model at 3- and 6-months of age. Our results suggest CTSA selectively contributes to processing of bioactive peptides in different tissues from CTSAS190A mice compared to age matched WT mice.

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Section: Discussionmentioning

confidence: 99%

Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides

Timur

Demir

Seyrantepe

2016

Front. Mol. Biosci.

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“…Studies of rats (73) and monkeys (74) have found an age-related decrease in central OTergic activity, but no human data are available. Postmortem studies of brain tissue taken from elderly subjects affected by Alzheimer's disease have led to mixed findings of decreased (75), increased (76), or unchanged OTergic activity (77), thus leaving the field open to further investigation.…”

Section: Human Studiesmentioning

confidence: 99%

Learning About Oxytocin: Pharmacologic and Behavioral Issues

Chini

Leonzino

Braida

et al. 2014

Biological Psychiatry

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Despite the accumulating evidence suggesting that the neuropeptide oxytocin (OT) plays a role in neuropsychiatric disorders characterized by social dysfunction, the influence of OT on the nonsocial aspects of learning and memory have been less investigated. To foster research in this area, we review the effects of OT on learning and memory in animal models and humans. In healthy animal models, OT improves memory consolidation and extinction, but only if given at a low dose immediately after the acquisition phase. On the contrary, OT effects in healthy humans have been inconsistent; although, in this case, OT was always given before the acquisition phase and no dose-response curves have ever been drawn up. Interestingly, a specific impairment in the reversal of learning has been found in mice devoid of OT receptors and OT has been demonstrated to enhance fear extinction in rodents. All together, these data suggest that OT plays a role in elementary forms of behavioral flexibility and adaptive responses and support its therapeutic potential in neuropsychiatric disorders characterized by cognitive inflexibility and/or impairment (autism, schizophrenia, Alzheimer's disease, Parkinson disease, stroke, posttraumatic stress disorder). Accordingly, OT has been shown to improve cognitive flexibility in OT receptordeficient mice, and scattered findings indicate that intranasal OT has positive effects on the memory of patients with schizophrenia or posttraumatic stress disorders. Further studies of the therapeutic potential of OT as an enhancer of learning and memory are warranted.

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“…Studies of ageing rats have used more variable approaches to investigate age-related changes in the oxytonergic system. These studies have obtained evidence for an age-related decrease in central oxytonergic activity, including blunted oxytocin responses to stress [37] and reductions in the number of oxytocin receptors in various brain areas [38], but effects of exogenously administered oxytocin on social memory and depressive-like behavior seem to be preserved in ageing rats [39]. …”

Section: Ageingmentioning

confidence: 99%

Ageing and Oxytocin: A Call for Extending Human Oxytocin Research to Ageing Populations – A Mini-Review

2012

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Interest in oxytocin has increased rapidly over the last decades. Consequently, quite a number of studies have addressed the influence of oxytocin on social stress, perception, cognition, and decision making in healthy adults as well as in clinical samples characterized by some form of social disturbance. Surprisingly little research on oxytocin has focused on ageing populations. This is particularly striking in two areas of study: the role of oxytocin in grandparents’ behavior toward and bonding with their grandchildren and the effects of oxytocin on the neurocognitive processing of socioemotional stimuli. The current mini-review offers an overview of the literature on the involvement of oxytocin in parental behavior and neurocognitive functioning, and discusses the relevance of these findings to ageing individuals. As the literature shows that oxytocin is profoundly involved in parenting and in bonding throughout life, it is highly likely that oxytocin plays a role in grandparenting and bonding between grandparents and grandchildren as well. However, results obtained with younger adults may not be directly applicable to older individuals in yet another type of relationship. The possibility that age-related changes occur in the oxytocin system (which is at present unclear) must be taken into account. In addition, ageing impairs neurocognitive processes that are profoundly affected by oxytocin (including some aspects of memory and emotion recognition) and is associated with alterations in both structure and function of the amygdala, which is prominently involved in mediating effects of oxytocin. Research investigating the ageing oxytonergic system and studies focusing on the involvement of oxytocin in socioemotional neurocognitive processes and social behavior in elderly individuals, including grandparents, are therefore urgently needed.

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Reduced binding of oxytocin in the rat brain during aging

Cited by 38 publications

References 17 publications

Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides

Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides

Learning About Oxytocin: Pharmacologic and Behavioral Issues

Ageing and Oxytocin: A Call for Extending Human Oxytocin Research to Ageing Populations – A Mini-Review

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