Reduced Clinical Effect of Monofluorophosphate in the Presence of Sodium Lauryl Sulphate

Melsen, Birte; Rölla, Gunnar

doi:10.1159/000260716

Cited by 21 publications

(15 citation statements)

References 10 publications

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“…While SDS appears capable of impacting fluoride efficacy [Melsen and Rolla, 1983;Barkvol et al, 1988;Robinson et al, 2006;Zero, 2006;Vogel et al, 2015], this study did not find any meaningful difference in the effect of the 2 surfactant systems employed (which both contained a substantial level of SDS) on any of the study measures, suggesting that neither the chemical differences (varying concentration of SDS and presence or absence of tegobetaine cosurfactant) nor physical differences (different foaming of the 2 zinc dentifrices) meaningfully affected fluoride efficacy in this study.…”

Section: Discussioncontrasting

confidence: 53%

“…They also have the potential to modulate the physical state of the dentifrice as it contacts the enamel surface (e.g., via foaming) and thereby influence fluoride effectiveness. Some data indicate that sodium dodecyl sulfate (SDS, also known as sodium lauryl sulfate), an anionic surfactant commonly used in dentifrices, impedes delivery of fluoride to enamel [Melsen and Rolla, 1983;Barkvol et al, 1988;Zero, 2006], while other studies suggest it can assist penetration of fluoride through the plaque matrix [Robinson et al, 2006;Vogel et al, 2015].…”

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confidence: 99%

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A Randomized in situ Clinical Study of Fluoride Dentifrices on Enamel Remineralization and Resistance to Demineralization: Effects of Zinc

Creeth¹,

Karwal

Hara

et al. 2018

Caries Res

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This study aimed to determine the effect of zinc ions and F concentration in a dentifrice on remineralization of early caries lesions in situ and on resistance to subsequent demineralization. This was a single-center, 6-period, 6-product, blinded (examiner, subject, analyst), randomized (n = 62), crossover study. Products (all NaF) were: 0, 250, 1,150 and 1,426 ppm F (dose-response controls), “Zn-A” (0.3% ZnCl₂, 1,426 ppm F), and “Zn-B” (as Zn-A, with high-foaming surfactants) in a conventional silica base. Subjects wore palatal appliances holding partially demineralized bovine enamel specimens. They brushed their teeth with 1.5 g test dentifrice (25 s), then swished the slurry ensuring even exposure of specimens (95 s), expectorated, and rinsed (15 mL water, 10 s). After 4 h intraoral remineralization, specimens were removed and acid-challenged in vitro. Surface microhardness (SMH), measured pre-experimental, post-initial acid exposure, post-remineralization, and post-second acid exposure, was used to calculate recovery (SMHR), net acid resistance (NAR), and a new, specifically demineralization-focused calculation, “comparative acid resistance” (CAR). Enamel fluoride uptake (EFU) was also measured. For the F dose-response controls, all measures showed significant relationships with dentifrice F concentration (p < 0.0001). The presence of zinc counteracted the ability of F to promote remineralization in this model. Compared to the 1,426 ppm F control, the zinc formulations gave reduced SMHR, EFU, and NAR (all p < 0.0001); however, they showed evidence of increased CAR (Zn-A: p = 0.0040; Zn-B: p = 0.0846). Products were generally well tolerated. In this study, increasing dentifrice F concentration progressively increased in situ remineralization and demineralization resistance of early caries enamel lesions. Zinc ions reduced remineralization but could increase demineralization resistance.

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Section: Discussioncontrasting

confidence: 53%

mentioning

confidence: 99%

A Randomized in situ Clinical Study of Fluoride Dentifrices on Enamel Remineralization and Resistance to Demineralization: Effects of Zinc

Creeth¹,

Karwal

Hara

et al. 2018

Caries Res

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“…Mellberg and Chomicki [1984] found that sodium lau ryl sulfate did not reduce the fluoride uptake in artifi cial caries lesions from sodium monofluorophos-phate dentifrices in vivo. On the other hand, Melsen and Rolla [1983] showed that sodium lauryl sulfate re duced the clinical effect of topically applied sodium monofluorophosphate and there is reason to assume that sodium lauryl sulfate affects the deposition of fluoride from sodium monofluorophosphate on enamel in the same way as from NaF [Barkvoll et al, 1987].…”

Section: Solubility O F Caf2 In Sodium Lauryl Sulfate Solutionsmentioning

confidence: 99%

“…When applied topically at fort nightly intervals, it has been shown that addition of sodium lauryl sulfate to an aqueous solution of so dium monofluorophosphate reduces the caries-inhib iting potential of the fluoride solution significantly [Melsen and Rolla, 1983]. Gron and Caslavska [1983] found that sodium lauryl sulfate in fluoride solutions for topical application did not interfere with deposi tion of firmly bound fluoride in enamel.…”

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confidence: 99%

Effect of Sodium Lauryl Sulfate on the Deposition of Alkali-Soluble Fluoride on Enamel in vitro

Barkvoll

Rölla²,

Lagerlöf³

1988

Caries Res

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There are indications that sodium lauryl sulfate may reduce the cariostatic effect of fluoride when present together with sodium monofluorophosphate during topical application. The aim of the present study was to examine the in vitro deposition of alkali soluble fluoride on enamel during topical application with sodium fluoride in combination with sodium lauryl sulfate. It was found that increasing amounts of lauryl sulfate decreased the amount of alkali soluble fluoride deposited on the enamel. The amount of fluoride deposited from toothpaste supernatants was less than that from aqueous solutions of NaF with the same concentration of fluoride. Enamel pieces, pretreated with sodium lauryl sulfate showed a reduced deposition of alkali-soluble fluoride after incubation in a fluoride solution. It was also observed that the presence of lauryl sulfate increased the solubility of CaF₂ in water.

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“…It is acknowledged that excipients in a toothpaste formulation could reduce the anticaries performance [33]. Similar interactions could affect the anticaries performance of mouthrinse.…”

Section: Discussionmentioning

confidence: 99%

Impact of an Anticaries Mouthrinse onIn VitroRemineralization and Microbial Control

Sun

Engelman

McGuire

et al. 2014

International Journal of Dentistry

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Objective. The objective of this research was to evaluate the caries control potential of a new fluoride mouthrinse that also contained antimicrobial agents and a biofilm disrupting agent using different in vitro models. Methods. Four in vitro studies were conducted to assess the performance of this three pronged approach to caries control: (1) traditional enamel fluoride uptake, (2) surface microhardness study using pH cycling model and subsequent fluoride uptake, (3) a salivary biofilm flow-through study to determine the anti-microbial activity, and (4) a single species biofilm model measuring effect on biofilm matrix disruption. Results. The data showed that a LISTERINE rinse with fluoride, essential oils and xylitol was superior in promoting enamel fluoride uptake and in enhancing antimicrobial activity over traditional commercially available fluoridated products. An increase of the surface microhardness was observed when the LISTERINE rinse was used in combination with fluoridated toothpaste versus the fluoridated toothpaste alone. Finally, it was demonstrated that xylitol solutions disrupted and reduced the biovolume of biofilm matrix of mature Streptococcus mutans. Conclusion. These in vitro studies demonstrated that a fluoride mouthrinse with antimicrobial agent and biofilm matrix disrupting agent provided multifaceted and enhanced anti-caries efficacy by promoting remineralization, reducing acidogenic bacteria and disrupting biofilm matrix.

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Reduced Clinical Effect of Monofluorophosphate in the Presence of Sodium Lauryl Sulphate

Cited by 21 publications

References 10 publications

A Randomized in situ Clinical Study of Fluoride Dentifrices on Enamel Remineralization and Resistance to Demineralization: Effects of Zinc

A Randomized in situ Clinical Study of Fluoride Dentifrices on Enamel Remineralization and Resistance to Demineralization: Effects of Zinc

Effect of Sodium Lauryl Sulfate on the Deposition of Alkali-Soluble Fluoride on Enamel in vitro

Impact of an Anticaries Mouthrinse onIn VitroRemineralization and Microbial Control

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