Reduced graft function (with or without dialysis) vs immediate graft function—a comparison of long-term renal allograft survival

Johnston, Olwyn; O’Kelly, Patrick; Spencer, S.; Donohoe, J.; Walshe, J. Joseph; Little, Dilly; Hickey, David P.; Conlon, Peter J.

doi:10.1093/ndt/gfl103

Cited by 108 publications

(93 citation statements)

References 12 publications

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“…According to the data of some authors, DGF has a negative impact (Johnston et al, 2006;Quiroga et al, 2006), while other studies have not found an effect (Boom et al, 2000;Sola et al, 2004). This difference is due to a number of factors.…”

Section: Discussionmentioning

confidence: 93%

“…Delayed graft function (DGF) is a frequent (10-50%) complication of the early post-transplantation period (Brier et al, 2003;Sánchez-Fructuoso et al, 2004;Azevedo et al, 2005;Johnston et al, 2006). Ischemia-reperfusion injury and the related graft tubulopathy cause incomplete or even missing function of transplanted kidney, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…In cases of missing function it is difficult to diagnose any pathologic changes arising in the graft during this period, for example, an acute rejection. The delayed diagnostics and lack of data regarding treatment of any eventual pathology may cause complications and loss of grafts both in the early and in the late post-operative period (Hernández et al, 2006;Johnston et al, 2006;Quiroga et al, 2006;Sánchez-Fructuoso et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Delayed Renal Graft Function in the Early Post-Transplant Period and its Impact on the Late Post-Transplant Results

Jušinskis¹,

Amerika²,

Maļcevs³

2013

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences

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Delayed renal graft function (DGF) is a frequent complication with negative impact on the course of early post-transplantation period. The data concerning the impact on the late results are contradictory. This study describes results of 5-year follow-up of 248 recipients after deceased donor renal transplantation. All patients were divided into two groups: with delayed graft function (DGF, n = 53) and immediate graft function, considered as the control group (IGF, n = 195). We evaluated factors that were associated with development of DGF and its impact on the survival of graft and recipient, and frequency of acute rejections and chronic dysfunctions. The rate of observed DGF was 21.4%. Its development was associated with the following factors: age of recipient and their weight, age of donor and their body mass index, high frequency of asystole/hypotension in donors prior to organ explantation (P < 0.05 for all), and longer time of cold ischemia (P = 0.058). The DGF group had higher rate of acute rejections (P < 0.001), and also lower 1.5 and 5-year graft survival and 1.5-year patient survival (P < 0.05 for all). The conclusion is that DGF has negative impact on the survival of renal grafts and patients, especially during the first 1.5 years after transplantation.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Delayed Renal Graft Function in the Early Post-Transplant Period and its Impact on the Late Post-Transplant Results

Jušinskis¹,

Amerika²,

Maļcevs³

2013

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences

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Section: Delayed and Slow Graft Functionmentioning

confidence: 99%

“…This group of patients can be defined as having intermediate graft function or slow graft function (18). The risk factors and the graft outcomes are likely similar to DGF, though less severe (18). This can possibly be explained by lesser severity kidney injury or lesser degree of baseline clinical or subclinical kidney dysfunction in the allograft (18).…”

Section: Delayed and Slow Graft Functionmentioning

confidence: 99%

Medical Management of the Kidney Transplant Recipient

Patel¹,

Lee²

2012

Current Concepts in Kidney Transplantation

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Contrast‐Enhanced Ultrasonography Value for Early Prediction of Delayed Graft Function in Renal Transplantation Patients

Song

Yao

et al. 2022

J of Ultrasound Medicine

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Objectives-Delayed graft function (DGF) is a common early complication after kidney transplantation. The aim of the present study was to evaluate the value of contrast-enhanced ultrasonography (CEUS) in the early prediction of DGF after kidney transplantation.Methods-A total of 89 renal transplant recipients were retrospectively enrolled and divided into DGF group or normal graft function (NGF) group according to the allograft function. Conventional Doppler ultrasound and CEUS examination data on the first postoperative day were collected and analyzed.Results-The resistive indices of segmental and interlobar artery in the DGF group were significantly higher than those in the NGF group (0.71 AE 0.17 versus 0.63 AE 0.08, P = .006; 0.70 AE 0.16 versus 0.62 AE 0.08, P = .004, respectively). The patients experiencing DGF had significantly lower PI-c (14.7 dB AE 6.1 dB versus 18.5 dB AE 3.3 dB, P = .001) and smaller AUC-c (779.8 AE 375.8 dBÁseconds versus 991.0 AE 211.7 dBÁseconds, P = .003), as well as significantly lower PI-m (12.6 dB AE 5.9 dB versus 15.9 dB AE 3.9 dB, P = .006), shorter MTT-m (30.7 AE 9.4 seconds versus 36.3 AE 7.1 seconds, P = .01), and smaller AUC-m (P = .007). Multivariate analysis demonstrated that PI-c, AUC-c, and MTT-m were independent risk factors for DGF. The area under the receiver operating characteristic curve values of the combined predicted value (PI-c + MTT-m, PI-c + AUC-c + MTT-m) of DGF incidence were bigger than that of PI-c, AUC-c, or MTT-m.Conclusions-CEUS parameters of the cortex and medulla have a good value for an early prediction of DGF after renal transplantation.

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Reduced graft function (with or without dialysis) vs immediate graft function—a comparison of long-term renal allograft survival

Cited by 108 publications

References 12 publications

Delayed Renal Graft Function in the Early Post-Transplant Period and its Impact on the Late Post-Transplant Results

Delayed Renal Graft Function in the Early Post-Transplant Period and its Impact on the Late Post-Transplant Results

Medical Management of the Kidney Transplant Recipient

Contrast‐Enhanced Ultrasonography Value for Early Prediction of Delayed Graft Function in Renal Transplantation Patients

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