Reduced olfactory sensitivity in subjects with depressive symptoms

Pollatos, Olga; Albrecht, J.; Kopietz, Rainer; Linn, Jennifer; Schoepf, Veronika; Kleemann, Anna Maria; Schreder, Tatjana; Schandry, Rainer; Wiesmann, Martin

doi:10.1016/j.jad.2006.12.012

Cited by 82 publications

(83 citation statements)

References 48 publications

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“…43 Two studies addressed possible relationship between depressive symptoms and olfactory function in non-clinical young adults. 44,45 In both studies, no association was found between olfactory discrimination and depressive symptoms assessed with the BDI. In one of these studies some correlation was observed between the BDI scores and olfactory thresholds measured with the Sniffin Sticks.…”

Section: Discussionmentioning

confidence: 84%

“…In one of these studies some correlation was observed between the BDI scores and olfactory thresholds measured with the Sniffin Sticks. 45 But the reported BDI scores (Յ9) suggest that all subjects had minimal, if any, depressive symptoms. 21,45 In the previous study we observed no correlation between the BDI scores (range: 3-33) and electrogustometric thresholds in 33 older adults without a history of psychiatric disorders.…”

Section: Discussionmentioning

confidence: 99%

“…45 But the reported BDI scores (Յ9) suggest that all subjects had minimal, if any, depressive symptoms. 21,45 In the previous study we observed no correlation between the BDI scores (range: 3-33) and electrogustometric thresholds in 33 older adults without a history of psychiatric disorders. 27 In line with this, no relationship between electrogustometric thresholds and depressive symptomatology measured with the GDS was found in the present study.…”

Section: Discussionmentioning

confidence: 99%

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Depressive symptoms and olfactory function in older adults

Ścińska

Wróbel

Korkosz

et al. 2008

Psychiatry Clin Neurosci

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Aims: Neuroimaging studies suggest a significant overlap between brain regions involved in the regulation of olfaction and mood. The aim of the present study was to search for correlations between depressive symptomatology measured by the 15-item Geriatric Depression Scale (GDS) and olfactory function assessed with Sniffin' Sticks in non-demented older adults (aged 53-79 years).Methods: Taste detection thresholds were also measured by means of electrogustometry on the anterior tongue. Results:No correlation was found between the GDS scores (range: 0-12) and olfactory thresholds or olfactory identification scores. Similarly, there was no relationship between depressive symptoms and electrogustometric thresholds. Subjects (n = 25) scoring Ն5 on the GDS were classified as 'depressed' and all other individuals (n = 60) were classified as 'nondepressed'. The two groups did not differ in terms of the olfactory measures and electrogustometric threshold. Conclusion:Depressive symptoms are not associated with any major olfactory deficit in non-clinical older adults.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Depressive symptoms and olfactory function in older adults

Ścińska

Wróbel

Korkosz

et al. 2008

Psychiatry Clin Neurosci

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“…Some studies suggest that they act by modulating the central neurotransmission (Komiya et al, 2006). A relation between the perception of odors and the emotional behavioral response has been suggested, showing neuroanatomical correlation (orbitofrontal cortex, amygdala, pyriform cortex, and insular and anterior cingulate cortex) between emotion and smell (Pollatos et al, 2007). Clinical studies suggest that the exposure to the inhalation of various kinds of essential oils is effective in reducing psychological stress, anxiety state, as well as the levels of cortisol in hypertensive patients (Hwang, 2006).…”

Section: Introductionmentioning

confidence: 99%

Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats

Leite¹,

Fassin²,

Baziloni³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: "Efeitos comportamentais em ratos após inalação do óleo essencial de Citrus aurantium L.". O óleo essencial de laranja (OEL) e seus constituintes obtidos da Citrus aurantium L. (Rutaceae) têm despertado interesse pela sua ação sedativa e relaxante. No presente estudo, ratos previamente expostos à inalação do OEL nas concentrações de 1,0%; 2,5% e 5,0%, p/v, durante 7 minutos em caixas de acrílico, foram avaliados em dois modelos de ansiedade: labirinto em cruz elevado (LCE) e campo aberto. O OEL na concentração de 2,5% aumentou tanto o tempo de permanência dos animais nos braços abertos do LCE, como o tempo de interação social ativa no campo aberto, tendo sido superior ao grupo padrão diazepam (1,5 mg/kg) ip. A diminuição do grau de emocionalidade dos animais observada nos dois modelos experimentais sugere uma possível ação central, o que está de acordo com o perfi l fi toquímico do óleo em estudo o qual mostrou a presença de limoneno (96,24%) e mirceno (2,24%), constituintes com comprovada atividade depressora sobre o sistema nervoso central. Unitermos:Óleo essencial, Citrus aurantium, Rutaceae, óleo de laranja, ansiedade, inalação, labirinto em cruz elevado. ABSTRACT:The orange essential oil (OEO) and its components obtained from Citrus aurantium L. (Rutaceae) has been attracting interest due to its sedative and relaxing actions. In the present study, rats previously exposed to OEO at the concentrations of 1.0%; 2.5% and 5.0%, w/w, by inhalation during 7 minutes in acrylic boxes were evaluated in two anxiety models: elevated plus maze (EPM) and open-fi eld. The OEO at the concentration of 2.5% increased both the time of the animals in the open arms of the EPM and the time of active social interaction in the open-fi eld being longer than that of the diazepam group (1.5 mg/kg i.p). In conclusion, the decrease in the level of emotionality of the animals observed in the two experimental models suggests a possible central action, which is in agreement with the phytochemical profi le of the oil under study, since it showed the presence of limonene (96.24%) and mircene (2.24%), components with a wellknown depressant activity on the central nervous system.

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“…The potential association between the olfaction and depression was fi rstly documented in the rodent model, where the bilaterally destroy of the olfactory bulb led to great alteration in the concentrations of dopamine and serotonin [14] and, in the end, resulting in depressive-like phenotypes [15]. Mounting evidence confi rmed that a close relationship existed between the dysfunctions in olfactory system and the occurrence of depression [16][17][18][19][20][21][22][23][24]. For reasons of clarity and brevity, the current review only summarized some key recent studies pertaining to the relationship between the dysfunctional olfaction and depression, to highlight potentially crucial roles of the normal olfactory system function in ameliorating the probability of the occurrence of depression.…”

Section: Introductionmentioning

confidence: 99%

A Short Glance at the Role of Olfaction in Depression

Zhou¹,

Lu²,

Lin³

et al. 2017

Arch Depress Anxiety

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Depression as one kind of neuropsychiatric disorder affects tons of population in the world and exerts great economic and social burden. Great efforts have been made during the past decades aiming to decipher the underlying mechanism of this mental disease. Different kinds of mechanisms underlie depression, among which malfunctions in the olfactory system is one important reason. The occurrence of depression has a close association with dysfunctions in the olfactory system, which is highlighted by some brain regions responsible for depression overlapping with areas playing crucial roles in olfaction. The close relationship between olfactory malfunctions and depression is also underscored by the evidence that some patients with depression exhibited a higher probability of odor identifi cation impairment and a reduced olfactory sensitivity as well as smaller olfactory bulb volumes. For reasons of concise and clarity, in the current review we only briefl y summarized some key recent studies pertaining to the relationship between the dysfunctional olfaction and depression, to underscore potentially crucial roles of the normal olfactory system function in ameliorating the probability of the occurrence of depression.

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Reduced olfactory sensitivity in subjects with depressive symptoms

Cited by 82 publications

References 48 publications

Depressive symptoms and olfactory function in older adults

Depressive symptoms and olfactory function in older adults

Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats

A Short Glance at the Role of Olfaction in Depression

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