The soft exosuit is an emerging robotics, which has been proven to considerably reduce the metabolic consumption of human walking and running. However, compared to walking, relatively few soft exosuits have been studied for running. Many soft exosuits used for running are worn on the back and with a heavy weight load, which may cause instability while running and potentially increase metabolic consumption. Therefore, reducing the weight of the whole soft exosuit system as much as possible and keeping the soft exosuit close to the center of gravity, may improve running stability and further reduce metabolic consumption. In this paper, a portable waist-loaded soft exosuit, the weight of which is almost entirely concentrated at the waist, is shown to assist hip flexion during running, and justifies choosing to assist hip flexion while running. As indicated by the experiments of motion flexibility, wearing the waist-loaded soft exosuit can assist in performing many common and complex motions. The metabolic consumption experiments proved that the portable waist-loaded soft exosuit reduces the metabolic consumption rate of wearers when jogging on the treadmill at 6 km per hour by 7.79% compared with locomotion without the exosuit. Additionally, at the running speed of 8 km per hour, using the waist-loaded soft exosuit can reduce metabolic consumption rate by 4.74%. Similarly, at the running speed of 10 km per hour, it also can be reduced by 6.12%. It is demonstrated that assisting hip flexion for running is also a reasonable method, and wearing the waist-loaded soft exosuit can keep human motion flexibility and reduce metabolic consumption.