Reduction in QSART and vasoactive intestinal polypeptide expression in the skin of Parkinson’s disease patients and its relation to dyshidrosis

Kawada, Morihiro; Tamada, Yasuhiko; Simizu, Hirokazu; Yanagishita, Takeshi; Yamashita, Noriko; Ishida, Natsuko; Watanabe, Daisuke; Yoshida, Mari; Ibi, Tatsu; Sahashi, Kou; Hashizume, Yoshio; Matsumoto, Yoshinari

doi:10.1111/j.1600-0560.2008.01086.x

Cited by 13 publications

(8 citation statements)

References 19 publications

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“…Reduced uptake in MIBG scintigraphy strongly pinpoints toward a degeneration of peripheral sympathetic neurons (Satoh et al, ). Moreover, peripheral impairment of sudomotor function measured by QSART could be detected in PD patients (Kawada et al, ) showing pathological values even in very early stages (Oh, Lee, Seo, Sohn, & Lee, ). Moreover, postmortem analysis revealed a severe degeneration of tyrosine hydroxylase positive noradrenergic peripheral axons in PD (Amino et al, ).…”

Section: Discussionmentioning

confidence: 99%

Reduced central sympathetic activity in Parkinson's disease

et al. 2019

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ObjectiveWith a combination of different sympathetic tests, we aimed to elucidate whether impairment of sympathetic function in Parkinson's disease (PD) is the consequence of a central or peripheral efferent dysfunction.MethodsThirty‐five patients with early‐to‐intermediate PD (median age: 63 years; IQR: 57–67 years; disease duration 1–9 years, 15 women) and 20 age‐ and sex‐matched healthy controls (median age: 64.5 years; IQR: 58–68 years; 10 women) were recruited. Autonomic testing was performed in two subgroups and included the assessment of resting cardiovascular parameters, postprandial hypotension (PPH), orthostatic hypotension (OH), and vasoconstriction induced by intradermal microdialysis with different concentrations of norepinephrine (NE; 10–5; 10–6; 10–7; 10–8) and by cold through forehead cooling. We also used sympathetic multiunit microneurography (muscle sympathetic nerve activity; MSNA; burst frequency (BF): bursts per minute; burst incidence (BI): bursts per 100 heart beats) and evaluated the presence of phosphorylated α‐synuclein deposits in skin innervation in biopsies from the thighs by immunohistohemistry.ResultsDiastolic blood pressure was higher in the PD group at rest (p < .001) and during OH (F = 6.533; p = .022). Vasoconstriction induced by NE microdialysis and cold was unchanged in PD patients. MSNA was lower in PD patients than in controls (BF: p = .001; BI: p = .025). Phosphorylated α‐synuclein deposits could be found only in PD patients.ConclusionWe did not find indications for peripheral sympathetic nerve fiber dysfunction or adrenoreceptor sensitivity changes. The decreased MSNA argues in favor of central sympathetic impairment.

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Section: Discussionmentioning

confidence: 99%

Reduced central sympathetic activity in Parkinson's disease

et al. 2019

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“…There have been only a few studies using this method, indicating reduced53 and normal axon reflex sweating 54…”

Section: Autonomic Testsmentioning

confidence: 99%

Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology

Asahina

Vichayanrat

Low

et al. 2012

Journal of Neurology, Neurosurgery & Psychiatry

111

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Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by motor dysfunction ( parkinsonism) and several non-motor features. Dysautonomia is a significant non-motor feature as well as a neuropsychiatric symptom. Autonomic dysfunction can occur even in the early stages of PD, often preceding the onset of the classic motor symptoms of PD. The patterns of autonomic features in PD are different from other parkinsonian disorders. Detection of autonomic dysfunction may therefore be helpful in diagnosing PD in the early or pre-motor stages, and/or in differentiating it from other parkinsonian disorders, such as multiple system atrophy and progressive supuranuclear palsy. The aim of this review is to describe aspects of autonomic dysfunction, including symptoms, assessment and pathophysiology, resulting from autonomic impairment in PD and other parkinsonian syndromes.

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“…The impulse then travels orthodromically down that axon to evoke a sweat response which is recorded. In PD patients with confirmed sympathetic cardiac denervation, the QSART was found to be normal suggesting selective loss of post-ganglionic catecholaminergic but not cholinergic nerves[35], while another study found QSART responses to be lower in PD compared to controls[36]. Skin sympathetic peroneal nerve activity has also been found to be lower in PD compared to controls[37], suggesting postganglionic sympathetic sudomotor lesions in PD.…”

Section: Skin and Sweat Glandsmentioning

confidence: 99%

Multi-organ autonomic dysfunction in Parkinson disease

Jain

2011

Parkinsonism & Related Disorders

102

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Both pathologic and clinical studies of autonomic pathways have expanded the concept of Parkinson disease (PD) from a movement disorder to a multi-level widespread neurodegenerative process with non-motor features spanning several organ systems. This review integrates neuropathologic findings and autonomic physiology in PD as it relates to end organ autonomic function. Symptoms, pathology and physiology of the cardiovascular, skin/sweat gland, urinary, gastrointestinal, pupillary and neuroendocrine systems can be probed by autopsy, biopsy and noninvasive electrophysiological techniques in vivo which assess autonomic anatomy and function. There is mounting evidence that PD affects a chain of neurons in autonomic pathways. Consequently, autonomic physiology may serve as a window into non-motor PD progression and allow the development of mechanistically based treatment strategies for several non-motor features of PD. End-organ physiologic markers may be used to inform a model of PD pathophysiology and non-motor progression.

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Reduction in QSART and vasoactive intestinal polypeptide expression in the skin of Parkinson’s disease patients and its relation to dyshidrosis

Abstract: Reduction in QSART and VIP expression in the sweat glands might be involved in the dyshidrosis of PD patients.

Cited by 13 publications

References 19 publications

Reduced central sympathetic activity in Parkinson's disease

Reduced central sympathetic activity in Parkinson's disease

Autonomic dysfunction in parkinsonian disorders: assessment and pathophysiology

Multi-organ autonomic dysfunction in Parkinson disease

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