Reduction of Atherosclerosis in Cholesterol-Fed Rabbits and Decrease of Expressions of Intracellular Adhesion Molecule-1 and Vascular Endothelial Growth Factor in Foam Cells by a Water-Soluble Fraction of Polygonum multiflorum

Abstract

Abstracts. Polygonum multiflorum stilbeneglycoside (PMS) is a water-soluble fraction of Polygonum multiflorum Thunb., one of the most famous tonic traditional Chinese medicines, that has protective effects on the cardiovascular system. The purpose of the present study is to elucidate the effects of PMS on macrophage-derived foam cell functions and the reduction of severity of atherosclerosis in hypercholesterolemic New Zealand White (NZW) rabbits. NZW rabbits were fed for 12 weeks with a normal diet, a high cholesterol diet, or a high cholesterol diet associated with irrigation with different doses of PMS (25, 50, or 100 mg / kg). Treatment of NZW rabbits fed with high cholesterol diet with 100 mg / kg PMS attenuated the increase in plasma cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and plasma triglyceride. Treatment with 50 and 100 mg / kg PMS caused 43% and 60% decrease in atherosclerotic lesioned area ratio to total surface area, respectively. In U937 foam cells, PMS could decrease the high expression of intercellular adhesion molecule (ICAM)-1 protein and the vascular endothelial growth factor (VEGF) protein levels in the medium induced by oxidized lipoprotein when analyzed by flow cytometry. The results proved that PMS is a powerful agent against atherosclerosis and that PMS action could possibly be through the inhibition of the expression of ICAM-1 and VEGF in foam cells.

The protective effects of Polygonum multiflorum stilbeneglycoside preconditioning in an ischemia/reperfusion model of HUVECs

“…Lv et al demonstrated that PMS could increase the activities of SOD and glutathione peroxidase (GSH-Px) in the serum and organs (liver, heart, and brain) of senile rats and decrease the level of 2-thiobarbituric acid-reactive substances (TBARS) in vivo [20] . Additionally, PMS was found to possess an anti-atherosclerotic and hypolipidemic activity [21] . Therefore, PMS may have protective effects against I/R injury.…”

Molecular analysis of a type III polyketide synthase gene in Fallopia multiflora

“…is one of the most important and widely used Chinese medicinal plants belonging to Polygonaceae family, and is officially listed in the Chinese Pharmacopoeia (China Pharmacopoeia Committee 2005). In traditional Chinese medicine, both the rhizomes and the old stems are used as tonic in many remedies for anemia, neurasthenia, and hypercholesterolemia (Yang et al 2005;Wang et al 2009). The clinically demonstrated major bioactive compounds of F. multiflora are various aromatic polyketides including stilbenes and anthraquinones (Lin et al 2003;Yao et al 2006); more precisely, 2,3,5,4'-tetra-hydroxy-stilbene-2-O-β-D-glucoside (TSG), emodin, rhein, physcion and chrysophanol.…”

Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ

“…ICAM-1 (Intracellular Adhesion Molecule 1) is a molecule involved in attraction and adhesion of inflammatory cells to endothelial and epithelial cells, and its soluble form, sICAM-1, is linked to activation of these cells in pathological responses [38]. It is up-regulated in liver associated diseases, such as in hepatitis C [38].…”