Reduction of Serum Cholesterol and Hypercholesterolemic Atherosclerosis in Rabbits by Secoisolariciresinol Diglucoside Isolated From Flaxseed

Prasad, Kailash

doi:10.1161/01.cir.99.10.1355

Cited by 262 publications

(231 citation statements)

References 29 publications

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“…We also observed a significant increased in the plasma MDA level which serves as the marker of lipid peroxidation in these category patients. This finding is similar to the study of Prasad and Kalra; 25 they reported an increased in the blood MDA concentration in rabbits with a high cholesterol diet. We also observed a direct correlation between plasma concentration of MDA and plasma concentration of triglyceride, total cholesterol, LDLcholesterol, systolic BP and diastolic BP and on the other hand an inverse correlation with HDL cholesterol and HDL-Chol/TC ratios in both sexes.…”

Section: Discussionsupporting

confidence: 92%

Plasma Lipid Peroxidation and Total Antioxidant Status among Dyslipidaemic and Hypertensive Nigerians with High Risk of Coronary Heart Disease

Ogunro

Wo²,

Idogun³

et al. 2009

West African Journal of Medicine

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BACKGROUND:The oxidative modification hypothesis of atherosclerosis predicts that low density lipoprotein-cholesterol (LDL-C) oxidation is an early event in atherosclerosis and that oxidized LDL-C contributes to atherogenesis OBJECTIVE: To determine a link, if any, between the plasma lipid peroxidation and total antioxidant status (TAS) among dyslipidemic and hypertensive Nigerian patients with high risk of coronary heart disease. METHODS: The study groups comprised 58 hypertensive adult Nigerians whose fasting plasma total cholesterol (TC) levels were > 5.5mmol/L and with high risk coronary heart disease (CHD) lipid fraction i.e. 'the ratio of high density lipoprotein cholesterol to total cholesterol' (HDL-C/TC) < 0.13 were selected for the study. (5,87 ± 0.23mmol / L et 4,65 ± 0,34 mmol / L) 53, p <0,50, p <0,001), cependant une corrélation directe entre le MDA / TC (r = 0,51, p <0,48, p <0,01) chez les hommes hypertendus ont été trouvés. Dans les sujets de sexe féminin à la moyenne ± écart-type plasma TC (5,45 ± 1,04 mmol / L) RÉSUMÉ CONTEXTE: La modification hypothèse oxydative de l'athérosclérose prédit que des lipoprotéines de faible densité-cholestérol (LDL-C), l'oxydation est un événement précoce dans l'athérosclérose et que l'oxydation du LDL-C contribue à l'athérogenèse. Objectif: déterminer un lien éventuel entre le plasma et de la peroxydation lipidique total antioxidant status (TAS) et les dyslipidemic nigérian patients hypertendus à haut risque de maladie coronarienne. MÉTHODES: Les groupes d'étude comprenait 58 hypertendus adultes Nigérians dont le plasma à jeun de cholestérol total (CT) ont été> 5.5mmol / L et avec un risque élevé de maladie coronarienne (CHD) de lipides c'est-à-dire la fraction «le taux de cholestérol des lipoprotéines de haute densité pour le cholestérol total" (HDL-C/TC) <0,13 ont été retenus pour l'étude. Les groupes de contrôle comprenant 58 adultes hypertendus non avec les Nigérians (HDL-C/TC

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Section: Discussionsupporting

confidence: 92%

Plasma Lipid Peroxidation and Total Antioxidant Status among Dyslipidaemic and Hypertensive Nigerians with High Risk of Coronary Heart Disease

Ogunro

Wo²,

Idogun³

et al. 2009

West African Journal of Medicine

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“…Hypercholesterolemic atherosclerosis is associated with an increase in the level of the lipid peroxidation product malondialdehyde, which is an index of the level of oxygen free radicals (34,35). A decrease in lipid per oxidation leads to a reduction in arterial wall choles terol content.…”

Section: Discussionmentioning

confidence: 99%

Influence of Amla (Emblica officinalis Gaertn.) on Hypercholesterolemia and Lipid Peroxidation in Cholesterol-Fed Rats

Kim

Yokozawa

Kim

et al. 2005

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effects of amla on low-density lipoprotein (LDL) oxidation and cholesterol levels were investigated in vitro and in vivo using Cuetinduced LDL oxidation and choles terol-fed rats. SunAmla and ethyl acetate (EtOAc) extract of amla significantly inhibited thiobarbituric acid (TBA)-reactive substance level in the Cu2+-induced LDL oxidation and the effects were stronger than those of probucol. In addition, the administration of SunAmla (at a dose of 20 or 40mg/kg body weight/d) or EtOAc extract of amla (at a dose of 10 or 20mg/kg body weight/d) for 20 d to rats fed 1% cholesterol diet significantly reduced total, free and LDL-cholesterol levels in a dose-dependent manner, and EtOAc extract of amla exhibited more potent serum cholesterol-lowering effect than SunAmla in the same amount. Furthermore, the oxidized LDL level in serum was markedly elevated in choles terol-fed control rats as compared with normal rats, while it was significantly decreased by the administration of SunAmla or EtOAc extract of amla. Moreover, the serum TBA-reactive substance level was also significantly decreased after oral administration of SunAmla or EtOAc extract of amla. These results suggest that amla may be effective for hypercholester olemia and prevention of atherosclerosis.

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“…This evidence suggests that there could be increased OR production contributing to the genesis of atherosclerosis. (Prasad, 1998;Kapoor and Prasad, 1996;Babior, 1984;Baynes, 1991 (Fantone and Ward, 1982;McCord and Fridovich, 1973;McCord, 1985). Moreover, the ubiquitous flavin cytosolic enzyme xanthine oxidase catalyzes the formation of superoxide anions from hypoxanthine and oxygen (Babior et al 1973).…”

Section: Oxygen Radicals and Atherosclerosismentioning

confidence: 99%

“…Reactive oxygen species have been demonstrated in growth signaling pathways and in smooth muscle cell proliferation (Colavitti et al 2002;Abe and Berk, 1999;Bhunia et al 1997). Reactive oxygen species have been suggested in the development of hypercholesterolemic atherosclerosis Prasad, 1999;Prasad, 2005;Prasad, 1997b;Prasad, 1998). Antioxidants attenuate/ prevent the development of atherosclerosis in cholesterol-fed rabbits and in humans Prasad, 1999;Prasad, 2005;Prasad, 1997a).…”

Section: Hypothesismentioning

confidence: 99%

Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

et al. 2006

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Restenosis is one of the major adverse outcomes of Percutaneous CoronaryIntervention (PCI). Previous studies have shown conflicting reports for homocysteine as a predictor of restenosis following PCI. The conflicting reports may be due to oxidative factors (stimulation of polymorphonuclear leukocyte [PMNL]-induced reactive oxygen species generation, xanthine-xanthine oxidase, and arachidonic acid metabolism) other than homocysteine which could cause endothelial cell dysfunction leading to restenosis.Malondialdehyde (MDA), a lipid peroxidation product, is a marker for oxidative stress and is related to all oxidative factors. Therefore, it is possible that serum MDA may be a better predictor of restenosis than plasma homocysteine. The purpose of this study is to determine whether or not the pre-procedural serum MDA and plasma homocysteine levels are elevated in patients who develop restenosis post PCI.The study included fifty-one patients undergoing elective PCI who consented to participate in a protocol that was approved by the Ethics Committee of the University of Saskatchewan. Homocysteine and malondialdehyde were measured in the plasma and serum respectively. Blood samples were collected pre-procedural, 0 time, 8 hours, 24 hours, and 6 months post-procedure. Exercise tolerance tests were performed at two weeks, and six months post-procedure to determine if there was any evidence of restenosis.The results of the study showed that pre-procedural values of plasma homocysteine in the restenosis and non-restenosis groups were 10.37 ± 0.46 and 10.73 ± 0.49 respectively. These values were not significantly different (p=0.60) between the groups. The pre-procedural levels of plasma homocysteine were not significantly ii different (p=0.08) from the post-PCI values of those patients who did not develop restenosis at the 6-month time interval. However, the pre-procedural levels of plasma homocysteine were significantly different from the post-PCI values of those patients in the restenosis group at the 24hr (p=0.04) and 6-month (p=0.002) time intervals. In the restenosis group there was a significant increase (24%) after six months in the values of homocysteine from the pre-procedural levels. Thus, this indicates that restenosis is associated with higher post-PCI levels of homocysteine.The pre-procedural levels of serum MDA in the restenosis and non-restenosis groups were 0.124± 0.16 and 0.147± 0.02 respectively. There was no significant difference (p=0.60) between the two groups. There was also no significant difference The results suggest that pre-procedural levels of plasma homocysteine and serum MDA were not predictors of restenosis following PCI. However, the post-PCI sixmonth levels of both homocysteine and MDA are predictors of restenosis. Moreover, the post-PCI levels of MDA were better predictors of restenosis than the post-PCI levels of homocysteine because the increase in MDA levels were greater at six months than the rise in homocysteine levels at the same time interval.iii ACKNOWLEDGEMENTS

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Reduction of Serum Cholesterol and Hypercholesterolemic Atherosclerosis in Rabbits by Secoisolariciresinol Diglucoside Isolated From Flaxseed

Cited by 262 publications

References 29 publications

Plasma Lipid Peroxidation and Total Antioxidant Status among Dyslipidaemic and Hypertensive Nigerians with High Risk of Coronary Heart Disease

Plasma Lipid Peroxidation and Total Antioxidant Status among Dyslipidaemic and Hypertensive Nigerians with High Risk of Coronary Heart Disease

Influence of Amla (Emblica officinalis Gaertn.) on Hypercholesterolemia and Lipid Peroxidation in Cholesterol-Fed Rats

Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

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